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FUGE-MIC Trondheim - Small Animal MR Imaging and Spectroscopy
In 2003 the Norwegian
Research Council awarded a dozen Norwegian laboratories status as
national
FUGE core facilities.
In partnership with the Department
of Anatomy and
Cell Biology at the
University of Bergen, we run laboratories for molecular imaging in FUGE.
Equipment Personnel Services Publications Innovation Links Hands-on Training Course |
News November, 2006: International Medical Imaging Seminar February 16-17th, 2007 at NTNU in Trondheim. The main purpose is to discuss the progress in MR and ultrasound imaging technology and the use of imaging of rodent models of disease with translation into clinical practice. [More information] October, 2006: FUGE MIC Trondheim joins the newly established Centre for Research Based Innovation which is a spin-off from our department: Medical Imaging Laboratory for Innovative Future Healthcare The CRI will focus on medical imaging and prepare the
grounds for cost-efficient health services and stimulate
industrial development. More user-friendly ultrasound equipment and
improved image quality in MR and ultrasound applications are main
topics. Head: Prof. Olav Haraldseth, Dept. of Circulation and Medical Imaging Research partner: SINTEF Business partners: GE Vingmed Ultrasound, FAST, Medistim, Mison, Odetect, Nordic NeuroLab, Cortechs Laboratories, St. Olavs Hospital, Helse Midt-Norge, MedTech Trondheim. September, 2006: ASL (Arterial Spin Labeling)-based perfusion mapping (FAIR-EPI) of rat and mouse brain is now implemented enabling us to perform a perfusion measurement in a time frame of minutes without use of contrast agents which will be especially useful in longitudinal studies. August, 2006: Our new double-tuned RF volume resonator for combined 1H and 13C applications is installed. To improve SNR 1H and 13C receive-only surface coils are available for mouse and rat brain. In addition, an in-house 13C transmit-receive surface coil is built and is in use specially designed for rat brain applications. For more information contact post.doc. Dr. Øystein Risa August, 2006: Researchers from Per Jynge's group has established in vivo heart imaging (CINE) of both rat and mice here at FUGE MIC Trondheim. For more information on these applications contact Research Scientist Dr. John Seland July, 2006: NTNU now offers an international M.Sc. degree in Medical Technology with Medical Imaging as one of five specializations. FUGE MIC Trondheim is part of the laboratory infrastructure available to M.Sc. candidates admitted to the Medical Technology programme [More] June 16, 2006: Tone Elise Døli and Mariann Heldahl submitted their M.Sc. reports on mapping of MR relaxation times in rat brain. We now offer a range of MR pulse sequences to produce parametric T1- and T2-maps in-vivo. May 6-12, 2006: Results from the lab are presented at the ISMRM in Seattle, USA. Links to abstracts: 1. In Vivo Echo Planar Diffusion Tensor Imaging ... 2. Semi-Automatic 3D Segmentation and CNR Measurement .... 3. Sequential Cerebral MRI of Listeria Brain Stem Encephalitis ..... 4. MEMRI of Rat Myocardium at 2.35T and 7T .... April 3-7, 2006: Three scientists from our lab (Goa, Thuen and Brekken) particpated in the Bruker Biopsin Advanced User Meeting in Ettlingen, Germany, covering pulse programming and advanced imaging. March 9-10, 2006: The first Scandinavian Bruker Users Workshop was arranged as a collaboration between Norwegian and Swedish users. This year our focus was on in vivo 13C MRS after a general introduction of the laboratories who joined the meeting. Two scientist from our lab (Risa and Brekken) partcipated with oral presentations. February 20, 2006: Post.doc. Tina Pavlin joins the lab to to work on image post-processing. Tina will contribute to the service offered by FUGE Molecular Imaging Center Trondheim. January 5, 2006: A dedicated small-animal ultrasound scanner (Vevo770) has been installed at our institute. The scanner has a range of probes and applications and is part of our FUGE Molecular Imaging Center. For questions concerning this laboratory contact Dr. Olav Eftedal January 2, 2006: Hands-on MRI/MRS Training Course 2006 will be arranged in our laboratories April 20.-21. More information here December 22, 2005: Our patent application for a new MR contrast agent is approved! December 13, 2005: Post.doc. Øystein Risa and co-workers from Prof. Ursula Sonnewalds group acquire their first 13C-MR spectra from rat brain in vivo at 7T with infusion of labelled glucose. This opens another avenue for studying metabolism by MR in our laboratories. November 4, 2005: NOFFOF-invited lecture on: MR and ultrasound imaging of rodents (Norwegian) October 2005: New equipment in the lab improves animal handling during MR experiments. A new dedicated mouse bed integrated into the 7T Biospec adds to the existing dedicated rat bed. September 29, 2005: Paper by Huszthy etal. accepted in Journal of Neurosurgery: Local delivery of species-specific endostatin improves anti-tumor efficacy. September 7-10, 2005: Posters presented at SMI 2005, Cologne, Germany: 1) Thuen etal.: Axon Sprouting in Frog and Fish Optic Nerve after Complete Transection Detected by MEMRI 2) Thuen etal.: Toxic Effects of MnCl2 on Adult Rat Retinoganglion Cells August 24, 2005: Paper by Brekke etal. accepted in Neuroimage: NG2-expression regulates vascular morphology and function in human brain tumours. July, 2005: EU COST B21-report completed after a Short Term Scientific Mission to the University of Surrey, UK. June 15, 2005: Invention concerning manganese-releasing alginates patented. May 28, 2005: First annual MRI/MRS Hands-on Training Course at FUGE MIC Trondheim. 10 participants from Oslo, Bergen and Trondheim join. The course will be repeated in the spring of 2006. May 7-13, 2005: Posters presented at ISMRM 2005, Miami, USA: 1) Alvestad etal.: Epileptogenesis: Brain Structure and Metabolism during the Latent Period following Kainate-induced Seizures in Rats 2) Thuen etal.: Visualization of the optic nerve in several laboratory animal models using manganese-containing contrast agents April 4-8, 2005: Two scientists from our lab (Risa and Brekken) particpate in the Bruker Biopsin Advanced User Meeting in Ettlingen, Germany, covering pulse programming and advanced imaging. March 7, 2005: Hands-on training course May 26th, 2005. February 21, 2005 : Paper by Thuen etal. accepted in Journal of Magnetic Resonance Imaging (JMRI): Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats. January 25, 2005: We are able to detect sprouting in the CNS of fish and frogs using 3D manganese-enhanced MRI (MEMRI). The results will be presented at the ISMRM 2005 in Florida, USA. January 21, 2005: Research Fellow Pål Erik Goa joins us to work on image post-processing. Pål Erik will contribute to the service offered by FUGE Molecular Imaging Centre Trondheim. January 3, 2005: Applications and protocols available on the new Biospec 7 Tesla now includes 1H MRI and MRS of mouse head/body, and rat head/body or similar species. Maximum object diameter is ~7 cm at 7 Tesla and ~19 cm at 2.4 Tesla. A range of RF coils are available. November 6, 2004: Our new 7T animal scanner is on field. A Bruker Biospin engineer will complete the installation within 1-2 weeks time. October 11-14, 2004: Oral presentation on improved experimental set-up: Bruker Biospin User Meeting 2004, Karlsruhe, Germany. September 9-12, 2004: Oral presentations at: 3rd Annual Meeting of the SMI, St. Louis, USA. and ESMRMB 2004, Copenhagen, Denmark. August 12, 2004: A new RF-coil set-up for 13C MR spectroscopic imaging will be available in our laboratory with the new 7T scanner. The set-up consists of a volume resonator for 13C excitation and 1H RF decoupling and a 13C receive-only rat brain surface coil to improve 13Carbon MR spectroscopic imaging sensitivity. August 7, 2004: The Society for Molecular Imaging has chosen our presentation on: 'A Novel Probe for Manganese Delivery' as a proffered talk and a Travel Grant Award at the Third Annual Meeting in St. Louis, USA, Sept. 9-12, 2004. July 15, 2004: Paper published in Cancer Research:"Collagenase increases the transcapillary presssure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts". July 5, 2004: Post.doc. Øystein Risa (to join the lab September 1) receives FUGE travel fund for training at leading 13Carbon MR spectroscopic imaging laboratory in Minnesota, USA. June 24, 2004: FUGE MIC Trondheim will arrange a new Hands-on Training Course in small-animal MRI in Trondheim in May 2005. Check the Hands-on Training Course link for details. June 20, 2004: Øystein Olsen joins our lab for the next 4 year to start his PhD on MR image analysis. June 18, 2004: ESMRMB 2004 in Copenhagen/Denmark accepts our abstract on Axon tracing in the rat optic nerve using mangafodipir for oral presentation in their EPOS Highlights Session on contrast agents. May 13, 2004: Jian Xu, medical research student, joins our lab for the next 5 years to work on projects related to diffusion tensor imaging. May 6, 2004: Paper accepted in Cancer Research: "Collagenase increases the transcapillary presssure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts". April 19-23, 2004 Trond E. Singstad and Christian Brekken participate on Bruker Biospin AG's "MRI/MRS Advanced Imaging Course" in Ettlingen, Germany. This course will serve as basis for the FUGE MIC Trondheim local course on MRI/MRS to be arranged early 2005 at the MR center in Trondheim. March 18, 2004: Installation of the NEW Bruker Biospec 7.0 T MR spectrometer dedicated for mice and rats is scheduled for week 43 (October 18). The bore size of the magnet is 21 cm, and the maximum diameter for objects to be scanned is 72 mm. The RF-coils delivered enables 1H MRI/MRS of brain and body of mice and rats, 13C MRS, and 23Na MRS. Other applictions can be adapted by adding modules of coils and electronics to the current spectrometer. February 20, 2004: ISMRM 2004 in Tokyo/Japan accepts Marte Thuen's abstract on Manganese-enhanced MRI of optic nerves for oral presentation in the session: 'White matter structure and function by MR imaging' January 15, 2004: Paper published in Cancer Research: "Radiation improves the distribution and uptake of liposomal doxorubicin (CaelyxTM) in human osteosarcoma xenografts". December 1, 2003: Agreement is reached between Bruker Biospin AB og NTNU on the matter of purchase of new dedicated small-animal MR-system. Delivery is late 2004. The magnet system ordered is an AS 7.0 Tesla Biospec with 400 mT/m max gradient strength and 21 cm bore size. We will keep our existing 2.35T animal scanner for imaging of larger objects. November 13, 2003: Paper accepted in Cancer Research: "Radiation improves the distribution and uptake of liposomal doxorubicin (CaelyxTM) in human osteosarcoma xenografts". September 18-21, 2003: Results from the NG2-receptor phenotyping of brain tumors by MRI is presented at ESMRMB2003 in Rotterdam. NG2-receptor status significantly affects tumor growth. September 1, 2003: Marte Thuen joins our group to start her Ph.D. on MRI of nerve damage and regeneration June 6, 2003: Open Tender is announced for purchase of new scanner in the TED-journal (english) and in "Norsk Lysningsblad" (norwegian). April 2003: Site visiting for new equipment (UK and Germany). New scanner will be purchased by tender process. April 1, 2003: Web-site published. Postal address: FUGE MIC Trondheim, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, N-7489 Trondheim, Norway Phone: +47 73 55 1354 Fax: + 47 73 86 7708 |
7T small animal MR
 CNS Damage and Repair  MRI of Myocardium   Nerve axon tracing in vivo   ACS - smart MR contrast   |
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updated September, 2006 by Christian.Brekken@ntnu.no |
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