http://hdl.handle.net/2282/343 Search the Channel search http://teora.hit.no/dspace/simple-search http://hdl.handle.net/2282/484 Title: Use of a disposable sheath system for flexible sigmoidoscopy in decentralized colorectal cancer screening <br/> <br/>Authors: Bretthauer, Michael; Hoff, Geir; Thiis-Evensen, Espen; Grotmol, Tom; Larsen, Inger K.; Kjellevold, Øystein; Skovlund, Eva <br/> <br/>Abstract: Background and Study Aims: To prevent transmission of infectious agents and to reduce instrument reprocessing time, the use of disposable sheath systems instead of conventionally reprocessed endoscopes has been promoted for flexible sigmoidoscopy. This trial primarily investigated the feasibility of a disposable sheath system for flexible sigmoidoscopy in decentralized colorectal cancer screening.Patients and Methods: In an ongoing colorectal cancer screening trial, 226 consecutive participants were randomly allocated to have their flexible sigmoidoscopy performed with either a fiberoptic sigmoidoscope covered with a disposable sheath (“EndoSheath group”) or a conventional video colonoscope (“standard colonoscope group”). All examinations were performed at a temporary screening center. The patients' experience was documented using a questionnaire. The feasibility of running temporary screening units was evaluated.Results: Examinations beyond the 60-cm level were excluded. Thus, 113 patients (examined with the disposable instrument) and 87 (standard instrument) were eligible for analysis. When the sheathed system was used, all the devices needed could be satisfactorily transported. A screening center could be set up within a few hours. No differences were observed in patient discomfort. Fewer patients with polyps were observed in the EndoSheath group (48 [42 %]), compared with 55 (63 %) in the standard colonoscope group; P = 0.005). No significant differences were observed for polyps larger than 5 mm (14 [12 %] in the EndoSheath group, 13 [15 %] in the standard colonoscope group; P = 0.6).Conclusions: Using the disposable system, decentralized colorectal cancer screening was easily established. However, fewer polyps were found, possibly due to the fiberoptic nature of the instrument. Sheathed video instruments are desirable and may increase the diagnostic yield. Mon, 29 Oct 2001 22:58:59 GMT http://hdl.handle.net/2282/483 Title: Med åpent blikk utenfor egen institusjon <br/> <br/>Authors: Hoff, Geir <br/> <br/>Abstract: Even in a country like Norway, with a poor reputation for investment in medical research, some studies may materialise against all odds. This is the story about the difficult start and first few years of flexible sigmoidoscopy screening studies in Norway. It started in the peripheral county of Telemark with the Telemark Polyp Study no. I (TPS-I) in 1983. We now see the success of the Norwegian Colorectal Cancer Prevention (NORCCAP) study, which is an on-going large-scale version of the TPS-I study comprising 21,000 men and women to be offered flexible sigmoidoscopy screening in Oslo and Telemark after randomised invitation from the population registry. Sun, 29 Oct 2000 22:58:59 GMT http://hdl.handle.net/2282/427 Title: Re: Baseline findings of the Italian multicenter randomized controlled trial of "once-only sigmoidoscopy"--SCORE <br/> <br/>Authors: Hoff, Geir; Bretthauer, Michael; Skovlund, Eva; Grotmol, Tom <br/> <br/>Description: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of the National Cancer Institute following peer review. The definitive publisher-authenticated version is available online at: http://dx.doi.org/10.1093/jnci/95.14.1089 Tue, 29 Oct 2002 22:58:59 GMT http://hdl.handle.net/2282/425 Title: CRC screening: review of the evidence and suggestions on when and how to move on from randomized trials to screening programmes <br/> <br/>Authors: Hoff, Geir Wed, 29 Oct 2003 22:58:59 GMT