Helge
Wiig
Professor
Besøksadresse:
Jonas Lies vei 91
5009 Bergen
Postadresse:
Postboks 7804
5009 Bergen
Telefon:
+47 55 58 63 87
+47 906 44 029
E-post:
Bøker
- 1994. Long term health effects of diving. ISBN: 82-7280-351-8.
- 1994. Long Term Health Effects of Diving.
Tidsskriftartikler
- 2014. Lymphatic function and responses in periodontal disease. Experimental Cell Research. 325: 130-137. doi: 10.1016/j.yexcr.2013.12.006
- 2014. Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood. BBA Clinical.
- 2013. Lymphangiogenesis and lymphatic function in periodontal disease. Journal of Dental Research. 92: 1074-1080. doi: 10.1177/0022034513504589
- 2013. Subcutaneous interstitial pressure and volume characteristics in renal impairment associated with edema. Kidney International. 84: 980-988. doi: 10.1038/ki.2013.208
- 2013. Increased WD-repeat containing protein 1 in interstitial fluid from ovarian carcinomas shown by comparative proteomic analysis of malignant and healthy gynecological tissue. Biochimica et Biophysica Acta - Proteins and Proteomics. 1834: 2347-2359. doi: 10.1016/j.bbapap.2013.05.011
- 2013. Interstitial fluid-A reflection of the tumor cell microenvironment and secretome. Biochimica et Biophysica Acta - Proteins and Proteomics. 1834: 2336-2346. doi: 10.1016/j.bbapap.2013.01.028
- 2013. High-salt diet increases hormonal sensitivity in skin pre-capillary resistance vessels. Acta Physiologica. 207: 577-581. doi: 10.1111/apha.12049
- 2013. Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema. Arteriosclerosis, Thrombosis and Vascular Biology. 33: 266-274. doi: 10.1161/ATVBAHA.112.300384
- 2013. Acute kidney failure with renal carcinomatous lymphangitis secondary to advanced colon cancer. Kidney International. 84: 420-420. doi: 10.1038/ki.2012.480
- 2013. Isolation of interstitial fluid and demonstration of local proinflammatory cytokine production and increased absorptive gradient in chronic peritoneal dialysis. American Journal of Physiology - Renal Physiology. 304: F198-F206. doi: 10.1152/ajprenal.00293.2012
- 2013. Renal ischemia-reperfusion (I/R) injury induces a rapid activation of local inflammatory markers and causes increased peritubular permeability. The FASEB Journal. 27:682:10. 1 sider.
- 2013. Loss of adipocyte specification and necrosis augment tumor-associated inflammation. Adipocyte. 2: 176-183. doi: 10.4161/adip.24472
- 2013. Increased interstitial osmolality in skin of rats on a high salt diet. The FASEB Journal. 27:680.2. 1 sider.
- 2013. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. Journal of Clinical Investigation. 123: 2803-2815. doi: 10.1172/JCI60113
- 2013. Effects of Hydration on Steric and Electric Charge-Induced Interstitial Volume Exclusion-a Model. Biophysical Journal. 105: 1276-1284. doi: 10.1016/j.bpj.2013.07.040
- 2012. PRESSURE-VOLUME RELATIONSHIPS IN THE INTERSTITIAL COMPARTMENT OF PATIENTS WITH RENAL DYSFUNCTION AND OEDEMA; CLINICAL CORRELATES AND IMPLICATIONS FOR VOLUME ASSESSMENT. Nephrology, Dialysis and Transplantation. 27: 514-514.
- 2012. A LOOK BEYOND BLOOD IN THE UREMIC SYNDROME: COMPARATIVE ANALYSIS OF INTERSTITIAL FLUID AND PLASMA IN KIDNEY DISEASE. Nephrology, Dialysis and Transplantation. 27: 48-48.
- 2012. Investigation of therapy resistance mechanisms in myeloid leukemia by protein profiling of bone marrow extracellular fluid. Espert Review of Proteomics. 9: 595-598. doi: 10.1586/EPR.12.55
- 2012. Effect of topical anaesthetics on interstitial colloid osmotic pressure in human subcutaneous tissue sampled by wick technique. PLoS ONE. 7. 5 sider. doi: 10.1371/journal.pone.0031332
- 2012. Minimally invasive quantification of lymph flow in mice and rats by imaging depot clearance of near-infrared albumin. American Journal of Physiology. Heart and Circulatory Physiology. 302: H391-H401. doi: 10.1152/ajpheart.00842.2011
- 2012. Gingival lymphatic drainage protects against porphyromonas gingivalis-induced bone loss in mice. American Journal of Pathology. 181: 907-916. doi: 10.1016/j.ajpath.2012.05.027
- 2012. Proteomic Evaluation of Inflammatory Proteins in Rat Spleen Interstitial Fluid and Lymph during LPS-Induced Systemic Inflammation Reveals Increased Levels of ADAMST1. Journal of Proteome Research. 11: 5338-5349. doi: 10.1021/pr3005666
- 2012. Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis. 15: 481-495. doi: 10.1007/s10456-012-9276-y
- 2012. Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. Physiological Reviews. 92: 1005-1060. doi: 10.1152/physrev.00037.2011
- 2011. A new method for isolation of interstitial fluid from human solid tumors applied to proteomic analysis of ovarian carcinoma tissue. PLoS ONE. 6. 9 sider. doi: 10.1371/journal.pone.0019217
- 2011. LTalpha CONTRIBUTES TO LYMPHATIC VESSEL DEVELOPMENT AND FUNCTION. Advances in Experimental Medicine and Biology. 691: 646-647.
- 2011. Salt-sensitive hypertension is paralleled by sodium storage, interstitial hypertonicity, and increased interstitial fluid pressure in the skin. Hypertension. 58: E59-E59.
- 2011. Pathophysiology of tissue fluid accumulation in inflammation. Journal of Physiology. 589: 2945-2953. doi: 10.1113/jphysiol.2011.206136
- 2010. Isolation of interstitial fluid in skin during volume expansion: evaluation of a method in pigs. American Journal of Physiology. Heart and Circulatory Physiology. 299: H1546-H1553. doi: 10.1152/ajpheart.01142.2009
- 2010. ISOLATION AND IDENTIFICATION OF INFLAMMATORY SPECIFIC PROTEINS IN INTERSTITIAL FLUID IN SKIN DURING ACUTE OVERHYDRATION. Intensive Care Medicine. 36: S407-S407.
- 2010. Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. Journal of Physiology. 588: 325-339. doi: 10.1113/jphysiol.2009.180463
- 2010. Importance of lymph vessels in transcapillary fluid balance in gingiva studied in a transgenic mouse model. American Journal of Physiology. Heart and Circulatory Physiology. 299: H275-H283. doi: 10.1152/ajpheart.01199.2009
- 2010. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood. 116: 2173-2182. doi: 10.1182/blood-2009-12-256065
- 2010. Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema. American Journal of Pathology. 176: 1122-1129. doi: 10.2353/ajpath.2010.090733
- 2010. Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation. Journal of Immunology. 184: 4547-4556. doi: 10.4049/jimmunol.0902049
- 2010. Interaction between the extracellular matrix and lymphatics: consequences for lymphangiogenesis og lymphatic function. Matrix Biology. 29: 645-656. doi: 10.1016/j.matbio.2010.08.001
- 2010. Interstitial fluid: the overlooked component of the tumor microenvironment? Fibrogenesis & tissue repair. 3. Publisert 2010-07-23. doi: 10.1186/1755-1536-3-12
- 2009. Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia. American Journal of Physiology. Heart and Circulatory Physiology. 296: H735-H744. doi: 10.1152/ajpheart.01309.2008
- 2009. Intravenous application of serum albumin reduces the tumour interstitial fluid pressure and increases the absorption of therapeutics in a xenograft model. Journal der Deutschen Dermatologischen Gesellschaft. 7: 237-237.
- 2009. Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model. Neoplasia. 11: 812-822.
- 2009. A combined immunostimulatory and immunoinhibitory sirna with anti-leukemic properties in a rat model of acute myeloid leukemia. Haematologica. 94: S30-S30.
- 2009. Dendritic cells loaded with tumor antigens and a dual immunostimulatory and anti-IL-10 specific siRNA can prime T lymphocytes against leukemic cells. Translational Oncology. 2: 242-246. doi: 10.1593/tlo.09154
- 2009. Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 297: R26-R33. doi: 10.1152/ajpregu.90617.2008
- 2009. The alpha 11 beta 1 integrin has a mechanistic role in control of interstitial fluid pressure and edema formation in inflammation. Arteriosclerosis, Thrombosis and Vascular Biology. 29: 1864-1870. doi: 10.1161/ATVBAHA.109.194308
- 2008. Application of serum albumin lowers tumour interstitial fluid pressure and increases the uptake of macromolecules in a xenograft tumour model. Journal of Investigative Dermatology. 128: S26-S26.
- 2008. A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. The FASEB Journal. 22: 3120-3128. doi: 10.1096/fj.08-109611
- 2008. Contribution of skeletal muscle to cytokine production in heart failure. Biophysical Journal. 94.
- 2008. Isolation of rat trachea interstitial fluid and demonstration of local cytokine production in lipopolysaccharide-induced systemic inflammation. Journal of applied physiology. 104: 809-820. doi: 10.1152/japplphysiol.00846.2007
- 2008. Peritumoral TNFalpha administration influences tumor stroma structure and physiology independently of growth in DMBA-induced mammary tumours. Scandinavian Journal of Clinical and Laboratory Investigation. 68: 602-611. doi: 10.1080/00365510801971703
- 2008. Peritumoral TNF alpha administration influences tumour stroma structure and physiology independently of growth in DMBA-induced mammary tumours. Scandinavian Journal of Clinical and Laboratory Investigation. 68: 602-611. doi: 10.1080/00365510801971703
- 2008. Plasma protein charge: a majon determinant of fluid exchange. Acta Physiologica. 194: 153-153. doi: 10.1111/j.1748-1716.2008.01906_2.x
- 2008. The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: Potential therapeutic consequences. Microcirculation. 15: 283-296. doi: 10.1080/10739680701671105
- 2007. Increased uptake of macromolecules in a xenograft tumour model is facilitated via enhanced colloid osmotic pressure. Journal of Investigative Dermatology. 127: S92-S92.
- 2007. Enhanced colloid osmotic pressure facilitates the uptake of macromolecules in a xenograft tumour model. European Journal of Cell Biology. 86: 11-11.
- 2007. Physiology and pathology of collagen receptors. Acta Physiologica. 190: 179-187. doi: 10.1111/j.1748-1716.2007.01718.x
- 2006. Lowering of interstitial fluid pressure in rat submandibular gland: a novel mechanism in saliva secretion. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1460-H1468. doi: 10.1152/ajpheart.00887.2005
- 2006. Cytokine signalling in rat pulp interstitial fluid and transcapillary fluid exchange during lipopolysaccharide-induced acute inflammation. Journal of Physiology. 573: 225-236. doi: 10.1113/jphysiol.2006.104711
- 2006. Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collagen to antibody penetration. Clinical Cancer Research. 12: 1906-1912. doi: 10.1158/1078-0432.CCR-05-2141
- 2006. Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model. Neoplasia. 8: 89-95.
- 2006. Increased colloid osmotic pressure enhances the uptake of macromolecules in a xenograft tumor model. Experimental Dermatology. 15: 238-238.
- 2006. Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema. Journal of Physiology. 574: 583-596. doi: 10.1113/jphysiol.2006.108308
- 2006. Differential degradation of matrix proteoglycans and edema development in rabbit lung. American Journal of Physiology - Lung cellular and Molecular Physiology. 290: L470-L477. doi: 10.1152/ajplung.00310.2005
- 2006. Interstitial colloid osmotic pressures after chronic endothelial no production contributes to peritoneal dialysis. Journal of Vascular Research. 43: 61-61.
- 2006. Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma. International Journal of Cancer. 11915: 2795-2802. doi: 10.1002/ijc.22217
- 2006. Isolation of interstitial fluid and identification inflammatory mediators in rat trachea. Journal of Vascular Research. 43: 69-69.
- 2005. Impaired hematopoiesis in acute myeloid leukemia is associated with elevated levels of tumor necrosis factor alpha and adiponectin in bone marrow, but not in plasma. Experimental Hematology. 33: 41-41.
- 2005. Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis. Clinical Cancer Research. 11: 6793-6799. doi: 10.1158/1078-0432.CCR-05-1033
- 2005. Fluid volume regulation parameters in a mouse model of primary lymphedema. The FASEB Journal. 19.
- 2005. The interstitial distribution of macromolecules in rat tumours is influenced by the negatively charged matrix components. Journal of Physiology. 567: 557-567. doi: 10.1113/jphysiol.2005.089615
- 2005. Extracellular distribution of monoclonal antibodies and other macromolecules in tumors. The FASEB Journal. 19.
- 2005. Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis. Clinical Cancer Research. 11: 6793-6799.
- 2005. Effect of hydration on interstitial distribution of charged albumin in rat dermis in vitro. Journal of Physiology. 569: 631-641. doi: 10.1113/jphysiol.2005.096792
- 2004. Isolation of interstitial fluid from skeletal muscle and subcutis in mice using a wick method. American Journal of Physiology. Heart and Circulatory Physiology. 287: H2085-H2090.
- 2004. Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in rats. Journal of Physiology. 556: 193-202.
- 2004. Acute peritoneal dialysis in rats results in a marked reduction of interstitial colloid osmotic pressure. Journal of the American Society of Nephrology. 15: 3111-3116.
- 2004. PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Blood. 104: 3198-3204.
- 2004. Demonstration of altered signaling responses in bone marrow extracellular fluid during increased hematopoiesis in rats using a centrifugation method. American Journal of Physiology. Heart and Circulatory Physiology. 286: H2028-H2034.
- 2004. The contribution of sterical and electrostatical factors on distribution of macromolecules in the interstitial space. Physiology News. 56: 29-30.
- 2003. Blood flow and interstitial fluid pressure in the rat submandibular gland during changes in perfusion. Journal of Dental Research. 82: 899-902.
- 2003. In vivo determination of steric and electrostatic exclusion of albumin in rat skin and skeletal muscle. Journal of Physiology. 552: 907-16.
- 2003. Interstitial exclusion of albumin in rabbit lung measured with the continuous infusion method in combination with the wick technique. Microcirculation. 10: 153-65.
- 2003. Interstitial exclusion of albumin in rabbit lung during development of pulmonary oedema. Journal of Physiology. 548: 907-17.
- 2003. Fluid pressure in human dermal fibroblast aggregates measured with micropipettes. American Journal of Physiology - Cell Physiology. 285: C1101-8.
- 2003. Isolation of interstitial fluid from rat mammary tumors by a centrifugation method. American Journal of Physiology. Heart and Circulatory Physiology. 284: H416-24.
- 2003. Effect of charge on interstitial distribution of albumin in rat dermis in vitro. Journal of Physiology. 550: 505-14.
- 2003. New and active role of the interstitium in control of interstitial fluid pressure: potential therapeutic consequences. Acta Anaesthesiologica Scandinavica. 47: 111-22.
- 2003. Simultaneous measurement of interstitial fluid pressure and load in rat skin after strain application in vitro. Annals of Biomedical Engineering. 31: 1246-1254.
- 2003. Simultaneous measurement of interstitial fluid pressure and load in rat skin after strain application in vitro. Annals of Biomedical Engineering. 31: 1246-54.
- 2001. Distribution spaces for hyaluronan and albumin in rat tail tendons. American Journal of Physiology. Heart and Circulatory Physiology. 281: H1589-H1597.
- 2001. Interstitial fluid pressure surrounding rat mesenteric venules during changes in fluid filtration. Experimental Physiology. 86: 33-38.
- 2001. Isolation of pulmonary interstitial fluid in rabbits by a modified wick technique. American Journal of Physiology - Lung cellular and Molecular Physiology. 280: L1057-L1065.
- 2001. Drainage of plasma proteins from renal medullary interstitium in rats. Journal of Physiology. 536: 533-539.
- 2001. Relationship between interstitial fluid volume and pressure (compliance) in hypothyroid rats. American Journal of Physiology. Heart and Circulatory Physiology. 281: H1085-H1092.
- 2001. Interstitial exclusion of positively and negatively charged IgG in rat skin and muscle. American Journal of Physiology. Heart and Circulatory Physiology. 280: H1505-H1512.
- 2000. Interstitial fluid pressure, composition of interstitium, and interstitial exclusion of albumin in hypothyroid rats. American Journal of Physiology. Heart and Circulatory Physiology. 278: H1627-H1639.
- 2000. Distribution of interstitial fluid pressure and fluid volumes in hind-limb skin of rats: relation to meridians? Clinical Physiology and Functional Imaging. 20: 242-249.
- 1999. High dose vitamin-C counteracts the negative interstitial fluid hydrostatic pressure and early edema generation in thermally injured rats. Burns. 25: 569-574.
- 1999. High dose Vitamin C counteracts the negative interstitial fluid hydrostatic pressure and early edema generation in thermally injured rats. Burns. 25: 569-574.
- 1997. The problem of gaining access to interstitial fluid. An attempt to rationalize a wicked discussion on wicks. Lymphology. 30: 111-115.
- 1997. Interstitial exclusion of macromolecules studied by graded centrifugation. American Journal of Physiology. Heart and Circulatory Physiology. 273 (42): H2794-H2803.
- 1996. Iontoforese - gammelt prinsipp - nye bruksområder. NAForum. 9: 26.
- 1992. Blockade of _b%b-Integrins in skin causes edema through lowering of interstitial fluid pressure. Circulation Research. 72: 978-983.
- 1991. Sampling interstitial fluid from rat skeletal muscle by intermuscular wicks. American Journal of Physiology. Heart and Circulatory Physiology. 261: 3: H155-H165.
Rapporter/avhandlinger
- 1994. Long term health effect of diving. Proceedings from an international consensus conference. [Mangler utgivernavn].
- 1986. Insterstitial fluid pressure and the relationship between interstitial fluid volume and pressure (compliance) in various organs and species.
Bokkapitler
- 2011. The interstitium and lymphatics have an important role in edema generation during sepsis. -, sider 297-306. I:
- 2011. Annual Update in Intensive Care and Emergency Medicine. Springer. 831 sider. ISBN: 978-3-642-18080-4.
- 1992. Interstitial fluid pressure in control of interstitial fluid volume during normal conditions, injury and inflammation. 476-485. I:
- 1992. Mechanics of Swelling. (Red.: Karalis, T. K.) NATO ASI Series.
- 1992. Interstitial fluid pressure in control of interstitial fluid volume during normal conditions, injury and inflammation. 475-485. I:
- 1992. NATO ASI Series, Series H: Cell Biology. (Red.: Karalis, T.K.).
- 1991. Arterial resistance in rat tail and kidney. 47-50. I:
- 1991. Resistance Arteries, strukture and function.