Kontor/besøk
Fysiologisk institutt, Universitetet i Oslo, P.O. Box 1103 Blindern, 0317 Oslo

Forskningsinteresser
Jeg leder et nevropsykologiske forskningsprogram hvor modellforsøk utføres i laboratoriet og resultatene av disse eksperimentene testes klinisk. Idag er gruppens mest aktive forskningsområde studier av sentralstimulerende medikamenters innflytelse på oppmerksomhetsproblemer, spesielt hyperaktive barns oppmerksomhetsproblemer. Til dette arbeidet benyttes en dyremodell, en rottestamme utviklet ved Kyoto universitet i Japan. Disse dyrene er både hyperaktive og har oppmerksomhetsdysfunksjoner. Vi har utarbeidet testmetodikk som ser ut til å egne seg for komparative studier. Denne metodikken bygger på operant psykologi og eksperimentell atferdsanalyse.

Publikasjoner
Johansen EB, Aase H, Meyer A, Sagvolden T. Related Articles, Books, LinkOut

Attention-deficit/hyperactivity disorder (ADHD) behaviour explained by dysfunctioning reinforcement and extinction processes.
Behav Brain Res. 2002 Mar 10;130(1-2):37-45. Review.
PMID: 11864716 [PubMed - indexed for MEDLINE]

Russell VA, de Villiers AS, Sagvolden T, Lamm MC, Taljaard JJ. Related Articles, Books, LinkOut

Methylphenidate affects striatal dopamine differently in an animal model for attention-deficit/hyperactivity disorder--the spontaneously hypertensive rat.
Brain Res Bull. 2000 Sep 15;53(2):187-92.
PMID: 11044595 [PubMed - indexed for MEDLINE
Sagvolden T. Related Articles, Books, LinkOut

Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD).
Neurosci Biobehav Rev. 2000 Jan;24(1):31-9. Review.
PMID: 10654658 [PubMed - indexed for MEDLINE]

Holene E, Nafstad I, Skaare JU, Krogh H, Sagvolden T. Related Articles, Books, LinkOut

Behavioural effects in female rats of postnatal exposure to sub-toxic doses of polychlorinated biphenyl congener 153.
Acta Paediatr Suppl. 1999 May;88(429):55-63.
PMID: 10419233 [PubMed - indexed for MEDLINE]

Holene E, Nafstad I, Skaare JU, Sagvolden T. Related Articles, Books, LinkOut

Behavioural hyperactivity in rats following postnatal exposure to sub-toxic doses of polychlorinated biphenyl congeners 153 and 126.
Behav Brain Res. 1998 Jul;94(1):213-24.
PMID: 9708851 [PubMed - indexed for MEDLINE]

Papa M, Berger DF, Sagvolden T, Sergeant JA, Sadile AG. Related Articles, Books, LinkOut

A quantitative cytochrome oxidase mapping study, cross-regional and neurobehavioural correlations in the anterior forebrain of an animal model of Attention Deficit Hyperactivity Disorder.
Behav Brain Res. 1998 Jul;94(1):197-211.
PMID: 9708850 [PubMed - indexed for MEDLINE]

Russell V, de Villiers A, Sagvolden T, Lamm M, Taljaard J. Related Articles, Books, LinkOut

Differences between electrically-, ritalin- and D-amphetamine-stimulated release of [3H]dopamine from brain slices suggest impaired vesicular storage of dopamine in an animal model of Attention-Deficit Hyperactivity Disorder.
Behav Brain Res. 1998 Jul;94(1):163-71.
PMID: 9708847 [PubMed - indexed for MEDLINE]

Boix F, Qiao SW, Kolpus T, Sagvolden T. Related Articles, Books, LinkOut

Chronic L-deprenyl treatment alters brain monoamine levels and reduces impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder.
Behav Brain Res. 1998 Jul;94(1):153-62.
PMID: 9708846 [PubMed - indexed for MEDLINE]

Berger DF, Sagvolden T. Related Articles, Books, LinkOut

Sex differences in operant discrimination behaviour in an animal model of attention-deficit hyperactivity disorder.
Behav Brain Res. 1998 Jul;94(1):73-82.
PMID: 9708841 [PubMed - indexed for MEDLINE]

Sagvolden T, Aase H, Zeiner P, Berger D. Related Articles, Books, LinkOut

Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder.
Behav Brain Res. 1998 Jul;94(1):61-71.
PMID: 9708840 [PubMed - indexed for MEDLINE]

Sagvolden T, Sergeant JA. Related Articles, Books, LinkOut

Attention deficit/hyperactivity disorder--from brain dysfunctions to behaviour.
Behav Brain Res. 1998 Jul;94(1):1-10. Review.
PMID: 9708834 [PubMed - indexed for MEDLINE]

Boix F, Woien G, Sagvolden T. Related Articles, Books, LinkOut

Short term storage of samples containing monoamines: ascorbic acid and glutathione give better protection against degradation than perchloric acid.
J Neurosci Methods. 1997 Jul 18;75(1):69-73.
PMID: 9262146 [PubMed - indexed for MEDLINE]

Papa M, Sagvolden T, Sergeant JA, Sadile AG. Related Articles, Books, LinkOut

Reduced CaMKII-positive neurones in the accumbens shell of an animal model of attention-deficit hyperactivity disorder.
Neuroreport. 1996 Nov 25;7(18):3017-20.
PMID: 9116231 [PubMed - indexed for MEDLINE]

Sadile AG, Pellicano MP, Sagvolden T, Sergeant JA. Related Articles, Books, LinkOut

NMDA and non-NMDA sensitive [L-3H]glutamate receptor binding in the brain of the Naples high- and low-excitability rats: an autoradiographic study.
Behav Brain Res. 1996 Aug;78(2):163-74.
PMID: 8864048 [PubMed - indexed for MEDLINE]

Russell V, de Villiers A, Sagvolden T, Lamm M, Taljaard J. Related Articles, Books, LinkOut

Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of attention-deficit hyperactivity disorder--the spontaneously hypertensive rat.
Brain Res. 1995 Apr 10;676(2):343-51.
PMID: 7614004 [PubMed - indexed for MEDLINE]

de Villiers AS, Russell VA, Sagvolden T, Searson A, Jaffer A, Taljaard JJ. Related Articles, Books, LinkOut

Alpha 2-adrenoceptor mediated inhibition of [3H]dopamine release from nucleus accumbens slices and monoamine levels in a rat model for attention-deficit hyperactivity disorder.
Neurochem Res. 1995 Apr;20(4):427-33.
PMID: 7651580 [PubMed - indexed for MEDLINE]

Sagvolden T, Pettersen MB, Larsen MC. Related Articles, Books, LinkOut

Spontaneously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behavior compared to four other rat strains.
Physiol Behav. 1993 Dec;54(6):1047-55.
PMID: 8295939 [PubMed - indexed for MEDLINE]

Sagvolden T, Metzger MA, Sagvolden G. Related Articles, Books, LinkOut

Frequent reward eliminates differences in activity between hyperkinetic rats and controls.
Behav Neural Biol. 1993 May;59(3):225-9.
PMID: 8503827 [PubMed - indexed for MEDLINE]

Sagvolden T, Metzger MA, Schiorbeck HK, Rugland AL, Spinnangr I, Sagvolden G. Related Articles, Books, LinkOut

The spontaneously hypertensive rat (SHR) as an animal model of childhood hyperactivity (ADHD): changed reactivity to reinforcers and to psychomotor stimulants.
Behav Neural Biol. 1992 Sep;58(2):103-12.
PMID: 1360797 [PubMed - indexed for MEDLINE]

Sagvolden T, Hendley ED, Knardahl S. Related Articles, Books, LinkOut

Behavior of hypertensive and hyperactive rat strains: hyperactivity is not unitarily determined.
Physiol Behav. 1992 Jul;52(1):49-57.