Searching for knowledge in the sea of data: search, analysis, and visualization in computational bio

11.06.2007

Foredragsholdere
Olga Troyanskaya

Date: Monday June 11th 2007, at 13:15
Place: Lille Aud or Store Aud (depends on the participation)
Title: " Searching for knowledge in the sea of data: search, analysis, and visualization in computational biology "

Abstract:
Now that genomic sequencing is a routine technology, the next key challenge in genomics is understanding protein function, interactions, and regulation. Experimental approaches to this problem generated vast amounts of diverse data, but an equivalent explosion in biological understanding has not yet followed the near- exponential growth in experimental results. I will discuss how computer science approaches for integrated analysis and dynamic, scalable visualization of these data combined with targeted, computation-driven experiments can address this gap and substantially contribute to our understanding of biology.

Specifically, I will discuss my group's work on development of novel methods for integration, analysis, and visualization of heterogeneous biological data. I will focus on our machine learning and search-based methods for function prediction, context-specific biological network modeling, and integrated analysis and large-scale, dynamic visualization of microarray data. In addition to the methods description, I will present the necessary biological background and describe novel discoveries that were made by our technology.

Throughout the talk, I will also outline related challenges for computer science and insights we gained in developing algorithms for these problems.

Bio:
Olga Troyanskaya is an Assistant Professor in the Department of Computer Science and the Lewis-Sigler Institute for Integrative Genomics at Princeton University, where she runs the Laboratory of Bioinformatics and Functional Genomics. Her work bridges computer science and molecular biology in an effort to develop better methods for analysis and visualization of diverse genomic data with the goal of understanding and modeling protein function and interactions in biological pathways. Dr. Troyanskaya is an associate editor for Bioinformatics, PLOS Computational Biology, and editorial board member of Journal of Biomedical Informatics, Briefings in Bioinformatics, and Biology Direct. She is also a member of the Board of Directors of the International Society for Computational Biology.

She received her Ph.D. from Stanford University and is a recipient of the Sloan Research Fellowship, the NSF CAREER award, and the Howard Wentz faculty award. She has also been honored as one of the top young technology innovators by the MIT Technology Review.

Links:
- Princeton University, Laboratory of Bioinformatics and Functional Genomics
- Princeton University, Lewis-Sigler Institute for Integrative Genomics
- Princeton University, Department of Computer Science, Bioinformatics Computational Biology


Potential questions in connection with Troyanskayas lecture can be directed to the host for her visit, professor Otto J. Anshus, telephone 7764 4038.


Welcome!