Ebrahim Aghajani

MD, PhD

E-post
ebrahim@fagmed.uit.no

Hovedoppgaver
Ebrahim Aghajani, MD; Truls Myrmel, MD, PhD; Arthur Revhaug, MD, PhD. et al.

MYOCARDIAL ENERGY TRANSFER IN SEPSIS

INTRODUCTION:
The hemodynamic pattern of septic shock is generally characterized by preserved or increased cardiac output and reduced systemic vascular resistance. An accompanying, but not fully understood, intrinsic myocardial dysfunction also plays an important role in septic shock. In both experimental and human septic shock, myocardial mechanical performance is reduced although myocardial oxygen consumption is increased or unchanged at any given work load. The mechanism behind energetic inefficiency in the septic myocardium is unknown.

Aims:
To study mechanism behind the mechanoenergetic inefficiency in the septic porcine left ventricle.

Papers:
1. E. Coli sepsis induces profound mechanoenergetic inefficiency in the porcine left ventricle.
Shock. 2004 Feb;21(2):103-9.

2. Increased oxygen cost of contractility in the endotoxemic porcine left ventricle.
Scand Cardiovasc J. 2004 Jun;38(3):187-92.

3. Mechanoenergetic inefficiency in the septic left ventricle is due to enhanced oxygen requirements for excitation-contraction coupling.
Cardiovasc Res. 2004 Aug 1;63(2):256-63.

4. The pressure-volume loop revisited: is the search for a cardiac contractility index a futile cycle?
Shock. 2006 Apr;25(4):370-6.