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Publications
2006
Stokke, R., Karlström, M., Yang, N., Leiros, I., Ladenstein, Birkeland, N-K., Steen, I.H. (2006) "X-ray structure analysis of isocitrate dehydrogenase from the hyperthermophile Archaeoglobus fulgidus: thermal stability and domain swapping." In press, Extremeophiles.
Wang, E., Koutsioulis, D., Leiros, H-K. S, Andersen, O.A., Hough, E., & Heikinheimo, P. (2006) "The Crystal Structure of Alkaline Phosphatase from the Antarctic strain TAB5." In press J. Mol. Biol.
Altermark, B., Niiranen, L., Willassen, N.P., Smalås, A.O., and Moe, E. (2006). "Comparative studies of endonuclease I from cold adapted Vibrio salmonicida and mesophilic Vibrio cholerae." In press FEBS Journal.
Niiranen L., Espelid, S., Karlsen, C.R., Mustonen, M., Paulsen, S.M., Heikinheimo, P. and Willassen, N.P. (2006) "Comparative expression study to increase the solubility of cold adapted Vibrio proteins in Escherichia coli." In press Protein Expression and purification.
Leiros, I., Wang, E., Rasmussen, T., Oksanen, E., Repo, H., Petersen, S.B., Heikinheimo, P. & Hough, E. (2006) "The 2.1Å crystal structure of Aerococcus viridans L-lactate oxidase (LOX)." In press Acta Cryst D.
Riise, E. K., Lorentzen, M. S., Helland, R., Smalås, A.O., Leiros, H-K. and Willassen, N. P. (2006) "The first crystal structure of a cold active catalase from Vibrio salmonicida at 1.96 Å reveals structural aspects of cold adaptation" In press, Acta Cryst D.
Olufsen, M., Brandsdal, B.O. and Smalås, A.O. (2006) "omparative unfolding studies of psychrophilic and mesophilic uracil DNA glycosylase: MD simulations show reduced thermal stability of the cold-adapted enzyme." In press Journal of Molecular Graphics and Modeling.
Papaleo, E., Olufsen, M., de Gioia, L. and Brandsdal, B.O. (2006). "Optimization of electrostatics as a strategy for cold-adaptation: A case study of cold- and warm- active elastases." In press Journal of Molecular Graphics and Modeling.
Ræder, I.L.U, Paulsen, S.M., Smalås, A.O. and Willassen, N.P. (2006). "Effect of fish skin mucus on the soluble proteome of Vibrio salmonicida analysed by 2-D gel electrophoresis and tandem mass spectrometry." In press Microbial Pathogenesis.
Altermark, B., Smalås, A.O., Willassen, N.P. and Helland, R. (2006). "The structure of Vibrio cholerae extracellular endonuclease I reveals the presence of a buried chloride ion." Acta Cryst. D, D62, 1387-91
Sørmo, C.G., Leiros, I., Brembu, T., Winge, P., Kristensen, R., Os, V. and Bones, A.M. (2006). "The crystal structure of Arabidopsis thaliana RAC7/ROP9, a plant specific Rho GTPase."Phytochemistry, 67, 2332-40
Adekoya, O. A, Willassen, N.P. and Sylte, I. (2006)" Molecular insight into pseudolysin inhibition using the MM-PBSA and LIE methods." J. Struct. Biol. 153, 129-44.
Lorentzen, M.S., Moe, E., Jouve, H. and Willassen, N.P. (2006). "Cold adapted features of Vibrio salmonicida catalase. Characterisation and comparison to the mesophilic counterpart from Proteus mirabilis."Extremophiles, 10, 427-440
Brandsdal, B.O., Smalås, A.O. and Åqvist, J. (2006) "Free energy calculations show that acidic P1 variants undergo large pKa shifts upon binding to trypsin. " Proteins.Proteins. 64, 740-748.
Hajjar, E., Korkmaz, B., Gauthier, F., Brandsdal, B.O, Witko-Sarsat, V. and Reuter, N. (2006) "Inspection of the binding sites of proteinase3 and design of a highly specific substrate." J. Med. Chem.49, 1248-1260.
Mekonnen, S.M., Olufsen, M., Smalås, A.O. and Brandsdal, B.O. (2006) "Predicting proteinase specificities from free energy calculations." J. Mol. Gra. Mod. 25, 176-185
Moe, E. Leiros, I., Smalås, A.O. & McSweeney, S. (2006) "The crystal structure of mismatch specific URAClL-DNA glycosylase (MUG) from Deinococcus radiodurans revels a noveal catalytic residue and broad substrate specificity." J. Biol. Chem., 281, 569-577.
Riise, E.K., Lorentzen, M.S., Helland, R. and Willassen, N.P. (2006) "Crystallisation and preliminary X-ray diffraction analysis of a cold adapted catalase from Vibrio salmonicida.”. Acta Cryst. F62, 77-79.
Adekoya, O. A, Helland, R., Willassen, N. P and Sylte, I. (2006) "Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family. " Proteins., 62,435-449.
Helland, R., Larsen, A.N., Smalås, A.O. and Willassen, N.P. (2006) The 1.8 Å crystal structure of a Proteinase K like enzyme from a psychrotroph Serratia species." FEBS J., 273, 61-71.
Larsen, A.N., Moe, E., Helland, R., Gjellesvik, D.R. and Willassen, N.P. (2006) "Characterization of a recombinantly expressed proteinase K like enzyme from a psychrotrophic Serratia sp." FEBS J., 273, 47-60.
Almlöf, M., Åqvist, J., Smalås, A.O. & Brandsdal, B.O. (2006) "Probing the effect of point mutations at protein-protein interfaces." Biophys. J., 90, 433-442.
2005
Thorvaldsen, S., Flå, T., and Willassen, N.P. (2005) "Extracting molecular diversity between populations through sequence alignments. Biological and Medical Data Analysis. " In Lecture Notes in Computer Science, Subseries: Lecture Notes in Bioinformatics, Vol. 3745, p317 – 328. Oliveira, J.L.; Maojo, V.; Martin-Sanchez, F.; Sousa Pereira, A. (Eds.)
Braun, F.N., Paulsen, S., Sear, R.P. and Warren, P.B (2005) "Miscibility gap in the microbial fitness landscape." Phys. Rev. Lett., 94, 178105.
Adekoya, O. A, Willassen, N. P and Sylte, I. (2005) "The protein-protein interaction between SMPI and Thermolysin studied by molecular dynamics and MM/PBSA calculations." J. Biomol. Struct. Dyn., 22, 521-531.
Krowarsch, D., Zakrzewska, M., Smalås, AO., and Otlewski, J. (2005) "Structure-Function Relationships in Serine Protease–Bovine Pancreatic Trypsin Inhibitor Interaction" Protein & Peptide Letter, 12, 403-407.
Leiros, I., Moe, E., Smalås, A.O. and McSweeney, S. (2005) "The crystal structure of Uracil-DNA N-Glycosylase (UNG) from Deinococcus radiodurans." Acta Cryst. D61. 61, 1049-1056.
Zavialov, A.V., Tischebko, V.M., Fooks, L.F., Brandsdal, B.O., Åqvist, J., Zav'yalov, V.P., MacIntyre, S. and Knight S.D. (2005) "Resolving the energy paradox of chaperone/usher-mediated fibre assembly." Biochemical J. 389, 685-694.
Olufsen, M., Smalås, A.O., Moe, E. and Brandsdal, B.O. (2005) "Increased flexibility as a strategy for cold-adaptation: A comparative MD study of cold-and warm-active Uracil DNA glycosylase" J. Biol. Chem.280, 18042-18048.
2004
Leiros, I., McSweeney, S. and Hough, E.(2004) "The reaction mechanism of Phospholipase D from Streptomyces sp. Strain PMF. Snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product.." J. Mol. Biol., 339, 805-820.
Czapinska, H., Helland, R., Smalås, A.O. and Otlewski, J. (2004) "Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants." J. Mol. Biol., 344, 1005-1020.
Moe, E., Leiros, I., Riise, E.K, Olufsen, M., Lanes, O., Smalås, A. O. & Willassen, N. P. (2004). ”Optimisation of electrostatic surface potential as strategies for cold adaptation of Uracil DNA glycosylase (UNG) from cod (Gadus morhua)." J. Mol. Biol., 343, 1221-1230.
Leiros, H.-K. S., Brandsdal, B.O. Andersen, O.A., Helland, R., Os, V., Otlewski, J., Leiros, I., Willassen, N.P. & Smalås, A.O. (2004) "Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements". Protein Science, 13, 1056-1070.
Stenvik, J., Solstad,T., Leiros,I.& .Jørgensen, T.Ø. (2004). ”Cloning and analysis of the BPI/LBP gene of the Atlantic cod (Gadus morhua L.).” Journal of Developmental and Comparative Immunology, Vol.28, 307-325.
Solem, S.T., Brandsdal, B.O , Smalås, A.O. & Jørgensen, T.Ø. (2004) “The primary structure and specificity determining residues displayed by recombinant salmon antibody domains.” Mol. Immunology, Vol. 40:1335-1348.
2003
Andersen OA, Stokka AJ, Flatmark T, Hough E. (2003) ”2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding.” J Mol Biol. 333(4), 747-757.
Leiros, I., Moe, E., Lanes, O., Smalås, A.O., & Willassen, N.P. (2003). ”The crystal structure of uracil-DNA-glycosylase from Atlantic cod (Gadus morhua) reveals cold-adaptation features”. Acta Cryst. D59, 1357-1365.
Heikinheimo, P., Helland, R., Leiros, H.K., Leiros,I., Karlsen, S., Evjen, G., Ravelli, R., Schoehn, G., Ruigrok, R., Tollersrud, .O.K., McSweeney, S. and Hough., E. (2003). “The Structure of Bovine Lysosomal alpha-Mannosidase Suggests a Novel Mechanism for Low-pH Activation.” J. Mol. Biol. 327(3), 631-644.
Heikinheimo, P., R. Helland, Leiros, H.K., Leiros, I., Karlsen, S., Evjen, G., Ravelli, R., Schoehn, G., Ruigrok, R., Tollersrud, .O.K., McSweeney, S. and Hough., E. (2003). "Structure of the Bovine Lysosomal a-mannosidase, the Enzyme Involved in the Lysosomal Storage Disease a-Mannosidosis." ESRF Highlights 2002: 12-13.
Helland, R., Czapinska, H., Leiros, I., Olufsen, M., Otlewski, J. & Smalås, A.O. (2003) “Structural Consequences of Accomodation of Four Non-cognate Amino Acid Residues in the S1 Pocket of Bovine Trypsin and Chymotrypsin” J. Mol. Biol. 333, 845-861.
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