Selected Publications:
   
 
 

Book

  • Fish Reproduction: Cytology, Biology and Ecology. (2007). M.J. Rocha, A. Arukwe and B.G. Kapoor, Eds: (Science Publishers), ISBN 1-57808-331-1.

Book Chapters

  • Arukwe, A. (2007). Fish estrogenic pathways: Chemical Disruption and Related Biomarkers. In Fish Reproduction: Cytology, Biology and Ecology Eds: M.J. Rocha, A. Arukwe and B.G. Kapoor (Science Publishers), pp. 471-514
  • Arukwe, A. (2006). Estrogen and aryl hydrocarbon receptor gene interactions – Expression profiling using toxicogenomic approach. In: Endocrine Disrupters. T. Grotmol, A. Bernhoft, G.S. Eriksen and T.P. Flaten, eds. Oslo: The Norwegian Academy Science and Letters 2006: 69-86.

Peer-reviewed research papers

  1. Arukwe., A. and K. Røe (2007). Molecular and Cellular Detection of Vitellogenin and Zona radiata Protein Expressions in the Liver and Skin of Juvenile salmon (salmo salar) Exposed to Nonylphenol. Cell Tissue Res. Doi: 10.1007/s00441-007-0543-y

  2. Vang, S.-H., Kortner, T.M. and A. Arukwe (2007). Steroidogenic acute regulatory (StAR) protein and Cholesterol side-chain cleavage(P450scc) as molecular and cellular targets for 17a-ethynylestradiol in salmon previtellogenic oocytes. Chem. Res. Toxicol. DOI: 10.1021/tx700228g.

  3. Mortensen, A.S and A. Arukwe (2007). Effects of 17a-Ethynylestradiol on Hormonal Responses and Xenobiotic Biotransformation System of Atlantic Salmon (Salmo salar). Aquat. Toxicol.  85: 113-123

  4. Kortner, T.M. and A. Arukwe (2007). Effects of 17a-methyltestosterone exposure on steroidogenesis and cyclin-B mRNA expression in previtellogenic oocytes of Atlantic cod (Gadus morhua). Comp. Biochem. Physiol. Part C, 146: 569-580

  5. Mortensen, A. S., and A. Arukwe (2007). Interaction between estrogen- and Ah-receptor pathways in primary culture of Salmon hepatocytes exposed to nonylphenol and 3,3',4,4'-tetrachlorobiphenyl (congener 77).  Comp. Hepatol, 6: 2

  6. Mortensen, A.S and A. Arukwe (2007). Targeted salmon gene array (SalArray): A toxicogenomic tool for gene expression profiling of interactions between estrogen- and Ah-receptor signalling pathways. Chem. Res. Toxicol. 20: 474-488.

  7. Bohne, V.B., Hamre, K. and A. Arukwe (2007). Hepatic phase I and II biotransformation enzymes in Atlantic salmon (Salmo Salar, L) during a twelve-week feeding period with graded levels of the synthetic antioxidant, ethoxyquin. Food Chem. Toxicol. 45: 733-746

  8. Mortensen, A.S and A. Arukwe (2007). Modulation of Xenobiotic Biotransformation System and Hormonal Responses in Atlantic salmon (Salmo salar) after Exposure to Tributyltin (TBT). Comp. Biochem. Physiol. Part C, 145: 431-441

  9. Mortensen, A.S., Braathen, M., Sandvik, M and A. Arukwe (2007). Effects of Hydroxy-Polychlorinated Biphenyl (OH-PCB) Congeners on the Xenobiotic Biotransformation gene expression patterns in Primary Culture of Atlantic salmon (Salmo salar) hepatocytes. Ecotoxicol. Environ. Saf. 68: 351-360.

  10. Kortner, T.M. and A. Arukwe (2007). The xenoestrogen, nonylphenol, impaired steroidogenesis in previtellogenic oocyte culture of Atlantic cod (Gadus morhua) by targeting the StAR protein and P450scc expressions. Gen. Comp. Endocrinol. 150:  419–429

  11. Lyssimachou, A. and A. Arukwe (2007). Alteration of brain and interrenal StAR protein, P450scc, and CYP11b mRNA levels in Atlantic salmon after nominal waterborne exposure to the synthetic pharmaceutical estrogen ethynylestradiol. J. Toxicol Environ Health, Part A, 70: 606-613. 

  12. Arukwe, A. (2006). Toxicological housekeeping genes: Do they really keep the House? Environ. Sci. Technol. 40: 7944-7949.

  13. Mortensen, A.S and A. Arukwe (2006). Suppression of aryl hydrocarbon receptor agonist (PCB-126)-induced CYP1A1 and UDPGT expression by xenoestrogenic nonylphenol in primary culture of salmon hepatocytes. Organohalogen Compounds 68: 572-575

  14. Ucan-Marin, F; A. Arukwe, G. Fox, G.W. Gabrielsen and R. Letcher (2006). Thyroid hormone transport in great lakes herring gull and svalbard glaucous gull: competitive transthyretin (TTR) binding of selected organohalogens. Organohalogen Compounds 68: 281-284

  15. Mortensen, A.S., Kortner, T.M. and A. Arukwe (2006). Thyroid hormone-dependent gene expression patterns in European common frog (Rana temporaria) tadpoles after short-term exposure to DDE. Biomarkers, 11: 524-537

  16. Pettersson, I., A. Arukwe, K. Lundstedt-Enkel, A.S. Mortensen and C. Berg (2006). Persistent Sex-Reversal and Oviducal Agenesis in Adult Xenopus tropicalis Frogs Following Larval Exposure to the Environmental Pollutant Ethynylestradiol. Aquat. Toxicol. 79: 356-365.

  17. Mortensen A.S. and A. Arukwe (2006). Dimethyl Sulfoxide is a potent modulator of Estrogen receptor isoforms and xenoestrogen biomarker responses in primary culture of salmon hepatocytes. Aquat. Toxicol. 79: 99-103

  18. Bohne, V.B., Hamre, K. and A. Arukwe (2006). Hepatic Biotransformation and Metabolite Profile During a Two-Week Depuration Period in Atlantic salmon Fed Graded Levels of the Synthetic Antioxidant, Ethoxyquin. Toxicol. Sci. 93: 11-21.

  19. Meucci, V. and A. Arukwe (2006). The environmental estrogen, 4-nonylphenol modulates brain estrogen-receptor- and aromatase (CYP19) isoforms gene expression patterns in Atlantic salmon (Salmo salar). Mar. Environ. Res. 62S1: S195-S199.

  20. Arukwe, A. (2006). Organ-specific Patterns of P450arom Gene Isoforms are modulated by the Organochlorine DDT metabolite, 1,1´-dichloro-2,2-bis[p-chlorophenyl]ethylene (p,p’-DDE), in Adult Male European Common Frog, Rana temporaria. Mar. Environ. Res. 62S1: S215-S218.

  21. Leiva-Presa, À., A.S. Mortensen, A. Arukwe and B.M. Jenssen (2006). Hepatic retinol and CYP26 levels in adult male European common frog (Rana temporaria) after subcutaneous exposure to the organochlorine metabolite p,p´‑DDE. Mar. Environ. Res. 62S1: S10-S15.

  22. Mortensen, A.S. and A. Arukwe (2006). The persistent DDT metabolite, DDE, alters thyroid hormone-dependent genes and hepatic CYP3A and the pregnane X receptor gene expressions in Atlantic salmon (Atlantic salmon (Salmo salar) parr. Environ. Toxicol Chem. 25 (6): 1607-1615.

  23. Lyssimachou, A., Jenssen, B.M. and A. Arukwe (2006). Brain cytochrome P450 aromatase gene isoforms and activity levels in Atlantic salmon after waterborne exposure to nominal environmental concentrations of the pharmaceutical ethynylestradiol and antifoulant tributyltin.Toxicol. Sci. 91: 82-92.

  24. McKinney, M.A., De Guise, S., Martineau, D., Béland, P., Arukwe, A. and R.J. Letcher (2006). Biotransformation of Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls in Beluga Whale (Delphinapterus leucas) Using An In Vitro Hepatic Microsomal Assay. Aquat. Toxicol. 77: 87-97.

  25. Meucci, V. and A. Arukwe (2006). Transcriptional modulation of Brain and hepatic estrogen receptor and P450arom isotypes in juvenile immature Atlantic salmon (Salmo salar) after waterborne exposure to the xenoestrogen, 4-nonylphenol. Aquatc. Toxicol.  77: 167-177

  26. Meucci, V. and A. Arukwe (2006). The Xenoestrogen, 4-nonylphenol modulates hepatic pregnane X receptor, aryl hydrocarbon receptor, CYP3A and CYP1A1 gene expressions in juvenile Atlantic salmon (Salmo salar). Comp. Biochem. Physiol. 142(1-2): 142-150.

  27. Mortensen, A.S., Tolfsen, C.C. and A. Arukwe (2006). Gene expression patterns in estrogen- (nonylphenol) and AH-receptor agonists (PCB-77) interaction using rainbow trout (Oncorhynchus mykiss) primary hepatocyte culture. J. Toxicol. Environ. Health, 69: 1-19.

  28. Arukwe, A (2005). Modulation of brain steroidogenesis by affecting transcriptional changes of steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc) in juvenile Atlantic salmon (Salmo salar) is a novel aspect of nonylphenol toxicity. Environ. Sci. Technol. 39: 9791-9798.

  29. Arukwe, A. and B.M. Jenssen (2005).  Differential Organ Expression Patterns of Thyroid Hormone Receptor Isoform Genes in p,p’-DDE-treated Adult Male Common Frog, Rana temporaria. Environ. Toxicol. Pharmacol. 20: 485-492

  30. Meucci, V. and A. Arukwe (2005). Detection of vitellogenin and zona radiata protein expressions in surface mucus of immature juvenile Atlantic salmon (Salmo salar) exposed to waterborne nonylphenol. Aquat. Toxicol. 73: 1-10.
     
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