Pharmaceutical development and evaluation
Project Title:Combining Parabens in New Ways to Achieve Better Activity at Reduced Concentrations.
Objective/Research Question: Parabens are among the most widely used preservatives in medicines and allied products. Certain health issues, including hormone-like effects have been reported for parabens. The study aims to combine parabens in novel ways to achieve better activity, such that lower total concentrations can be used.
Contact at FHS: Associate Professor PhD Colin Charnock, Colin.Charnock@hf.hio.no
Cooperating in the project:Tore Finsrud, HiO; Norges Apotekerforening
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Project Title :Testing of Novel Derivatives of Metronidazole.
Objective/Research Question Metronidazole is an important antibiotic in the treatment of infections with anaerobic bacteria and protozoa. The chemical structure of metronidazole has been modified in various ways to produce a series of novel derivatives; these are currently being screened for activity.
Contact at FHS: Associate Professor PhD Colin Charnock, Colin.Charnock@hf.hio.no
Cooperating in the project: Professor Jo Klaveness, UiO (project leader)
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Project Title : Synthesis and Antibacterial Activity of Agelasine and its Analogues.
Objective/Research Question: Agelasines are 7,9-dialkylpurinium salts which show activity against a number of bacterial species including Mycobacterium species. We are currently testing a number of analogues for antibacterial activity.
Contact at FHS: Associate Professor PhD Colin Charnock, Colin.Charnock@hf.hio.no
Cooperating in the project: Professor Lise-Lotte Gundersen, UiO (project leader)
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Project Title: Development of New Tattooing Colourants which Satisfy the Requirements of the European Commission.
Objective/Research Question: Tattooing colourants can be heavily contaminated with bacteria. However, new proposals from the European Commission will suggest that colorants in the future be produced without preservatives. We are currently testing a new range of colourants which use an ion exchange mechanism (instead of preservatives) as antimicrobial factor.
Contact at FHS: Associate Professor PhD Colin Charnock, Colin.Charnock@hf.hio.no
Cooperating in the project: Ralf Michel, Deep Colours GmbH.
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Project Title: Use of Anti-epileptic Medication for Patients at a SpecialistEpilepsyHospital (SSE)
Objective/Research Question: How are anti-epileptic drugs administered to in-patients at a specialist hospital, with focus on the introduction of new drugs, co-morbidity and combination treatment? This study relates the drug administration to user statistics and therapeutic recommendations.
Contact at FHS: Associate Professor PhD Cecilie Johannesen Landmark, Cecilie.Landmark@hf.hio.no
Cooperating in the project: Elisif Rytter and Svein I. Johannsesen, SSE
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Project Title: Molecular Mechanisms Effected by Anti-epileptic Drugs
Objective/Research Question: Anti-epileptic medication is used today for a range of other problems than epilepsy, e.g. bipolar disease, migraine, pain management. What are the mechanisms involved in the use of such drugs to treat these conditions?
Contact at FHS: Associate Professor PhD Cecilie Johannesen Landmark, Cecilie.Landmark@hf.hio.no
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