Bakgrunn og aktiviteter
Forskningsaktivitet
Myelomatose (beinmargskreft) er en kreftform som skyldes opphopning av maligne plasmaceller i beinmargen. Kreftcellene produserer faktorer som fører til at balansen mellom celler som lager bein (osteoblaster) og celler som spiser bein (osteoklaster) blir forstyrret, slik at beinet blir ødelagt. Jeg er særlig opptatt av å finne ut av hvordan dette skjer. Jeg forsker også på hvordan betennelse (inflammasjon) påvirker modningen og aktivteten til osteoblaster og osteoklaster.
Vitenskapelig, faglig og kunstnerisk arbeid
Et utvalg av nyere tidsskriftspublikasjoner, kunstneriske produksjoner, bok, inklusiv bokdeler og rapport-del. Se alle publikasjoner i databasen
Tidsskriftspublikasjoner
- (2015) Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices. PLoS ONE. vol. 10 (3).
- (2014) The Primary Function of gp130 Signaling in Osteoblasts is to Maintain bone Formation and Strength, Rather than Promote Osteoclast Formation. Journal of Bone and Mineral Research. vol. 29 (6).
- (2014) Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer Journal. vol. 4.
- (2014) gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation. Journal of Endocrinology. vol. 223 (2).
- (2013) Dickkopf-1 is associated with periarticular bone loss in patients with rheumatoid arthritis. Open Journal of Rheumatology and Autoimmune Diseases.
- (2013) Anti-c-MET Nanobody® – a new potential drug in multiple myeloma treatment. European Journal of Haematology. vol. 91 (5).
- (2012) Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC. Leukemia. vol. 26.
- (2012) Imatinib inhibits proliferation of human mesenchymal stem cells and promotes early but not late osteoblast differentiation in vitro. Journal of Bone and Mineral Metabolism. vol. 30 (1).
- (2012) Properties and cell compatibility of mineralized alginate hydrogel beads. European Cells and Materials. vol. 23.
- (2012) Investigation of mineralized alginate gels as a scaffold material for stem cell based bone tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. vol. 6.
- (2011) Association Between High Plasma Levels of Hepatocyte Growth Factor and Progression of Radiographic Damage in the Joints of Patients With Rheumatoid Arthritis. Arthritis and Rheumatism. vol. 63 (3).
- (2011) BONE MORPHOGENETIC PROTEINS INDUCE APOPTOSIS BY SMAD-DEPENDENT DOWNREGULATION OF MYC. Haematologica. vol. 96.
- (2011) CpG-ODN inhibits Smad-dependent BMP signaling; Effects on myeloma cell apoptosis and in vitro osteoblastogenesis. Bone. vol. 48 (1).
- (2010) DKK1, AN INHIBITOR OF BONE FORMATION IS AN INDEPENDENT PREDICTOR OF HAND BONE LOSS IN RHEUMATOID ARTHRITIS. Scandinavian Journal of Rheumatology. vol. 39.
- (2010) CpG-Oligodeoxynucleotide Inhibits Smad-Dependent Bone Morphogenetic Protein Signaling: Effects on Myeloma Cell Apoptosis and In Vitro Osteoblastogenesis. Journal of Immunology. vol. 185 (6).
- (2009) Does Toll-like Receptor 9 Signaling Play a Role in Myeloma Disease Progression?. Clinical Lymphoma & Myeloma. vol. 9.
- (2008) Hepatocyte growth factor (HGF) in the pathogenesis of multiple myeloma. Cellular Therapy and Transplantation. vol. 1 (1).
- (2008) High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. European Journal of Haematology. vol. 80.
- (2007) HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma. Blood. vol. 109 (7).
- (2006) Bone disease in multiple myeloma. Medical Oncology. vol. 23 (4).