Seksjon for Endokrinologi

Leder for forskningen innen endokrinologi er
Professor Eystein Husebye
 

Publikasjoner år 2002

Børud B, Hoang T, Bakke M, Jacob A, Lund J. and Mellgren G. The nuclear receptor coactivators p300/CBP/cointegrator-associated protein (p/CIP) and transcription intermediary factor 2 (TIF2) differentially regulate PKA-stimulated transcriptional activity of Steroidogenic Factor 1. Mol. Endocrinol. 2002; 16:757-773

Fladmark K, Brustugun OT, Mellgren G, Krakstad C, Bøe R, Vintermyr OK, Schulman H and Døskeland SO. Ca2+/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. J. Biol. Chem. 2002; 277:2804-2811

Gudmundsson FF, Gislason HG, Myking O, Viste A, Grong K, and Svanes K. Hormonal changes related to reduced renal blood flow and low urine output under prolonged increased intra-abdominal pressure in pigs. Eur. J. Surg. 2002; 168:178-186

Holm PI, and Kristoffersen EK. A Scandinavian case of domestically acquired human fascioliasis. Scand. J. Infect. Dis. 2002; 34:548-550

Johnson W, Omland T, Hall C, Lucas C, Myking O, Collins C, Pfeffer M, Rouleau, JL and Stevenson LW. Neurohormonal activation rapidly decreases after intravenous therapy with diuretics and vasodilators for class IV heart failure. J. Am. Coll. Cardiol. 2002; 39:1623-1629

Lund J, Børud B, Mellgren G, Æsøy R, Hoang T, Jacob A and Bakke M. Differential regulation of SF-1-cofactor interactions. Endocr. Res. 2002; 28:505-513

Mellgren G, Bleskestad IH, Aanderud S and Bindoff L. Thyrotoxicosis and paraparesis in a young woman: case report and review of the literature. Thyroid. 2002; 12:77-80

Steier JA, Bergsjø PB, and Myking O. Disappearance of human chorionic gonadotropin after cesarean section with regard to fetal sex. Acta Obstet. Gynecol. Scand. 2002; 81:403-406

Steier JA, Ulstein M and Myking O. Human chorionic gonadotropin and testosterone in normal and preeclamptic pregnancies in relation to fetal sex. Obstet. Gynecol. 2002; 100:552-556

Svarstad E, Myking O, Ofstad J and Iversen BM. Effect of light excercise on renal hemodynamics in patients with hypertension and chronic renal disease. Scand. J. Urol. Nephrol. 2002; 36:464-473

Mellgren G, Holm PI, Lien EA, Bleskestad IH, Aanderud S and Bindoff L. Tyreotoksisk periodisk paralyse - en uvanlig komplikasjon ved hypertyreose. Tidsskr. Nor. Laegeforen. 2002; 122:1029-1031

Myhre AG, Undlien DE, Løvås K, Uhlving S, Nedrebø, BG, Fougner K, Trovik T, Sørheim JI, Husebye ES. Autoimmune adrenocortical failure in Norway. Autoantibodies and HLA class II associations related to clinical features. J. Clin. Endocrinol. Metabol. 2002; 87:618-623

Bøe AS, Knappskog PM, Myhre AG, Sørheim JI, Husebye ES. Mutational analysis of the autoimmune regulator gene (AIRE) in sporadic autoimmune Addison`s disease can reveal patients with unidentified autoimmune polyendocrine syndrome type I. Eur. J. Endocrinol. 2002; 146:519-521

Løvås K, Loge JH, Husebye ES. Subjective Health Status in Norwegian patients with Addison's disease. Clin. Endocrinol. 2002; 56:581-588

Løvås K, Husebye ES. High prevalence and increasing incidence of Addison's disease. An epidemiological study in Western Norway. Clin. Endocrinol. 2002; 56: 787-791

Nesje LB, Varhaug JE, Husebye ES, Ødegaard S. Endoscopic ultrasonography for preoperative diagnosis and localization of insulinomas. Scand. J. Gastroenterol. 2002; 37: 732-737

Halonen M, Eskelin P, Myhre AG, Perheentupa J, Husebye ES, Kämpe O, Rorsman F, Peltonen L, Ulmanen I, Partanen J. Autoimmune Regulator and Human Leucocyte Antigen Genotypes as Determinants of the Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Phenotype. J. Clin. Endocrinol. Metabol. 2002; 87: 2568-2574

Nedrebø BG, Holm PI, Uhlving S, Sørheim JI, Skeie, S, Eide GE, Husebye ES, Lien EA, Aanderud S. Predictors of outcome and comparison of different drug regimens for the prevention of relapse in patients with Graves' disease. Eur. J. Endocrinol. 2002; 147, 583-589

Æsøy R, Mellgren G, Morohashi K, Lund J. Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor.1. Endocrinology. 2002; 143:295-303

Husebye ES. Hypotyreose. Tidsskr. Nor. Lægeforen. 2002; 122: 983

2003

Gudmundsson F, Viste A, Myking O, Grong K, Bostad L, and Svanes K. Effects of the endothelin-1 receptor antagonist tezosentan on renal blood flow and diuresis during prolonged increased intra-abdominal pressure. J. Surg. Res. 2003; 115:33-40

Gudmundsson F, Viste A, Myking O, Bostad L, Grong K. and Svanes K.
Role of angiotensin II under prolonged increased intraabdominal pressure (IAP) in pigs. Surg. Endosc. 2003; 17:1092-1097.

Decensi A, Robertson C, Viale G, Pigatto F, Johansson H, Kisanga ER, Veronesi P, Torrisi R, Cazzaniga M, Mora S, Sandri MT, Pelosi G, Goldhirsch A and Lien EA. A randomized trial of low-dose tamoxifen on breast cancer proliferation and blood estrogenic biomarkers. J. Natl. Cancer Inst. 2003; 95:779-790

Bonanni B, Johansson H, Gandini S, Guerrieri-Gonzaga M, Sandri MT, Mariette F, Lien EA and Decensi A. Effect of tamoxifen at low doses on ultrasensitive C-reactive protein in healty women. J. Thromb. Haemost. 2003; 1:2149-2152

Holm PI, Ueland PM, Kvalheim Gry and Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput metod based on normal-phase chromatography-tandem mass spectrometry. Clin. Chem. 2003; 49:286-294

Nedrebø BG, Hustad S, Schneede J, Ueland PM, Vollset SE, Holm PI, Aanderud S and Lien EA. Homocysteine and its relations to B-vitamins and smoking in Graves' disease before and after treatment. J. Intern. Med. 2003; 254:504-512

Steier JA, Bergsjø PB, Thorsen TE and Myking O. Human chorionic gonadotropin in maternal serum in relation to fetal gender and utero-placental blood flow. Acta Obstet. Gynecol. Scand. 2003; 82:1-5

Børud B, Mellgren G, Lund J and Bakke M. Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. Mol. Endocrinol. 2003; 17:2303-2319

Kisanga ER, Gjerde J, Schjøtt J, Mellgren G and Lien EA. Tamoxifen administration and metabolism in nude mice and nude rats. J. Steroid Biochem. Mol. Biol. 2003; 84:361-367

Mellgren G, Børud B, Hoang T, Yri OE, Fladeby C, Lien EA and Lund J. Characterization of receptor-interacting protein RIP140 in the regulation of SF-1 responsive target genes. Mol. Cell. Endocrinol. 2003; 91-103

Løvås K, Gebre-Medhin G, Trovik T, Fougner K, Uhlving S, Nedrebø, BG, Myking OL, Kämpe O, Husebye ES. Replacement of dehydroepiandrosterone in adrenal failure. No benefit for subjective health status in a placebo-controlled clinical trial. J. Clin. Endocrinol. Metabol. 2003; 88: 1112-1118

Sköldberg F, Portela-Gomes GM, Grimelius L, Nilsson G, Perheentupa J, Betterle C, Husebye ES, Gustafsson J, Rönnblom A, Rorsman F, Kämpe O. Histidine Decarboxylase is a Novel Autoantigen of Enterochromaffin-like Cells in Autoimmune Polyendocrine Syndrome Type 1. J. Clin. Endocrinol. Metabol. 2003; 88: 1445-1452

Løvås K, Husebye ES, Holsten F, Bjorvatn B. Sleep disturbances in patients with Addison's diseae. Eur. J. Endocrinol. 2003; 148: 449-456

Myhre AG, Årsetøy H, Undlien DE, Hovdenak N, Aksnes L, Husebye E. High frequency of coeliac disease among patients with autoimmune adrenocortical failure. Scand. J. Gastroenterol. 2003; 38: 511- 515

Løvås K, Cooper JG, Thorsen T, Thordarson H, Husebye ES. Døgnrytme til besvær. Tidsskr. Nor. laegeforen. 2003; 123:1858-1859

Husebye ES. Cushing syndrom. I Livsboka, En bok om Addison, Adrenogenitalt Syndrom, Akromegali Cushing og hypofysesvikt. Morbus Addison foreningen 2003; 49-56.

Løvås K, Husebye ES. Replacement therapy in Addison's disease. Curr. Opinion. Pharmacotherapy. 2003; 4:2145-2149

2004

Holm PI, Bleie Ø, Ueland PM, Lien EA, Refsum H, Nordrehaug JE, and Nygård O, Betaine, choline and dimethylglycine as determinants of total plasma homocysteine before and after B-vitamin supplementation. Arterioscler. Throm. Vasc. Biol, 2004; 24:301-307

Kisanga ER, Gjerde J, Guerrieri-Gonzaga A, Mariette F, Galli A, Pigatto F, Decensi A, and Lien EA. Tamoxifen and metabolite concentrations in human serum and breast cancer tissues during three different dosing regimens for four weeks. Clin. Cancer Res. 2004; 10:2336-2343

Hustad S, Nedrebø BG; Ueland PM, Schneeede, J, Vollset SE; Ulvik A. and Lien EA. Phenotypic expression of the methylenetetrahydrofolate reductase 677C->T polymorphism and flavine cofactor availability in thyroid dysfunction. Am. J. Clin. Nutr. 2004; 80:1050-1057.

Hoang T, Fenne I, Cook C; Bakke M, Lien EA, Børud B. and Mellgren G. cAMP-dependent protein kinase regulates ubiquitin-proteasome mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. J. Biol. Chem. 2004; 279:49120-49130

Kvistad PH, Løvås K, Boman H, and Myking O. Retarded bone growth in thyroid hormone resistance. A clinical study of a large family with a novel thyroid receptor mutation. Eur. J. Endocrinol. 2004; 150:425 - 430

Bøe AS, Bredholt G, Knappskog PM, Hjelmervik TO, Mellgren G, Winquist O, Kämpe O. and Husebye, Eystein S. Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison¹s disease are mainly immunoglobulin G1. Eur. J. Endocrinol. 2004; 150:49-56

Bøe AS, Bredholt G, Knappskog PM, Hjelmervik TO, Winqvist O, Kämpe O, Husebye ES, Serological reactivity suggests Th1 mediation of Addison's disease. Eur. J. Endocrinol. 2004; 150:49-56

Söderbergh A, Myhre AG, Mietinen A, Eskelin P, Ekwall O, Halonen M, Hedstrand H, Nilsson T, Landgren E, Tuomi, T, Gustafsson J, Husebye ES, Perheentupa J, Manns MP, Kämpe O, Rorsman F. Prevalence and Clinical Associations of Ten Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I. J. Clin. Endocrinol. Metabol. 2004; 89:557-62

Storstein A, Monstad SE, Nakkestad HL, Husebye ES, Vedeler CA. Paraneoplastic antibodies detected by a sensitive radiobinding assay. J. Neurology. 2004; 251:197-203

Sköldberg F, Rorsman F, Perheentupa J, Landin-Olsson M, Husebye ES, Gustafsson J, Kämpe O. Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate dependent enzyme, in endocrine autoimmune disease. J. Clin. Endocrinol. Metabol. 2004; 89:1636-1640

Blomhoff A, Lie BA, Myhre AG, Kemp EH, Weetman AP, Akselsen HE, Husebye ES, Undlien DE. Polymorphisms in the CTLA4 gene region confer susceptibility to Addison's disease. J. Clin. Endocrinol. Metabol. 2004; 89:3474-3476

Myhre AG, Stray-Pedersen A, Spangen S, Eide E, Veimo D, Knappskog PM, Abrahamsen TG, Husebye ES. Chronic mucocutaneous candidiasis and primary hypothyroidism in two families. Eur. J. Pediatr. 2004; 163:604-611

Bøe AS, Bredholt G, Knappskog PM, Storstein A, Vedeler CA, Husebye ES. Pyridoxal phosphatase is a novel cancer autoantigen in the central nervous system. Br. J. Cancer. 2004; 91:1508-14

2005

Blomhoff A, Helen Kemp E, Gawkrodger DJ, Weetman AP, Husebye ES, Akselsen HE, Lie BA, Undlien DE. CTLA4 polymorphisms are associated with vitiligo, in patients with concomitant autoimmune diseases. Pigment. Cell. Res. 2005; 18:55-8

Husebye ES, Sthoeger ZM, Dayan M, Zinger H, Elbirt D, Levite M, Mozes E. Antibodies to the NR2 glutamate receptor in systemic lupus erythematosus. Ann. Rheum. Dis. 2005 in press

Løvås K, Husebye ES. Addison's disease. The Lancet. 2005 in press

Løvås K, Erichsen MM, Husebye ES, Fougner KJ, Svartberg J, Mella B, Myhre AG, Berg JP, Aarskog D. Primary adrenal failure: causes, diagnostic, and therapy. Tidsskr. Nor. Laegeforen. 2005; 125:155-158

Løvås K, Erichsen MM, Husebye ES, Fougner KJ, Svartberg J, Mella B, Myhre AG, Berg JP, Aarskog D. Primary adrenal failure: causes, diagnostic, and therapy. Tidsskr. Nor. Laegeforen. 2005; 125:155-158

Holm PI, Ueland PM, Vollset SE, Midtun Ø, Blom HJ, Keijzer BAJ, den Heijer M. Betaine and folat status as cooperative determinants of plasma homocysteine in humans. Arterioscler. Thromb. Vasc. Biol. 2005; 25:379-385

Husebye ES, Sthoeger ZM, Dayan M, Zinger H, Elbirt D, Levite M, Mozes E. Autoantibodies to a NR2A peptide of the glutamate/NMDA receptor in sera of patients with systemic lupus erythematosus. Ann. Rheum. Dis. 2005 Feb 11; [Epub ahead of print]

 

Sist oppdatert 21.02.05 av A.U.