Optimization and Application Development of Marine Cold-adapted DNA Polymerases

Isothermal amplification methods are now increasingly being used for molecular detection of pathogens, and are considered an important contribution to improve both disease control and food safety analysis. The ambition of this proof of principle project is to verify and optimize enzymatic properties of selected recombinant marine cold-adapted polymerases necessary to further develop isothermal amplification technologies.

Crystals of marine cold-adapted polymerases: Starting point for structure determination and further improvement of enzymatic properties by rational design.

This is a 3 year project within the BIOTEK2021 programme from 10.2013-10.2016.

Ansvarlig for prosjektet: Atle Noralf Larsen