Johan
Fernø
Researcher
Visit Address:
Haukeland universitetssykehus, Laboratoriebygget
5021 Bergen
Postal Address:
Postboks 7804
5021 Bergen
E-mail:
Selected publications
- 2013. Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research. 54: 307-309. doi: 10.1194/jlr.E034736
Journal articles
- 2014. Hypothalamic mTOR: the rookie energy sensor. Current molecular medicine. 14: 3-21.
- 2014. Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats. Endocrinology. 155: 1679-1689. doi: 10.1210/en.2013-1839
- 2014. Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects. International Journal of Neuropsychopharmacology. 17: 91-104. doi: 10.1017/S1461145713000862
- 2013. Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research. 54: 307-309. doi: 10.1194/jlr.E034736
- 2013. Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research. doi: 10.1194/jlr.E034736
- 2012. Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology. 219: 783-794. doi: 10.1007/s00213-011-2397-y
- 2012. Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment. PLoS ONE. 7. 11 pages. doi: 10.1371/journal.pone.0050853
- 2012. Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. International Journal of Neuropsychopharmacology. 15: 163-179. doi: 10.1017/S1461145711001271
- 2012. Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes. 61: 807-817. doi: 10.2337/db11-1079
- 2011. Lipogenic effects of psychotropic drugs: focus on the SREBP system. Frontiers in Bioscience. 16: 49-60. doi: 10.2741/3675
- 2011. Olanzapine-induced hyperphagia and weight gain associate with crexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. PLoS ONE. 6. 9 pages. doi: 10.1371/journal.pone.0020571
- 2011. Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. Pharmacopsychiatry. 44: 15-20. doi: 10.1055/s-0030-1263174
- 2011. Lithium differentially affects clock gene expression in serum-shocked NIH-3T3 cells. Journal of Psychopharmacology. 25: 924-933. doi: 10.1177/0269881110379508
- 2010. Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples. Molecular Psychiatry. 15: 463-472. doi: 10.1038/mp.2008.110
- 2009. Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology. 203: 73-84. doi: 10.1007/s00213-008-1370-x
- 2009. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Molecular Psychiatry. 14: 308-317. doi: 10.1038/sj.mp.4002133
- 2009. Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells. BMC Pharmacology. 9. doi: 10.1186/1471-2210-9-10
- 2008. Effect of clozapine on memory function in the hippocampal lesion model of schizophrenia. International Journal of Neuropsychopharmacology. 11: 261-261.
- 2008. Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples. Molecular Psychiatry.
- 2008. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: pertubation of SREBP-controlled lipogenesis in drug-realted metabolic adverse effects? Molecular Psychiatry. 1-10. Published 2008-01-15.
- 2008. Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. International Journal of Neuropsychopharmacology. 11: 679-684.
- 2008. Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. International Journal of Neuropsychopharmacology. 11: 679-684. doi: 10.1017/S1461145708008468
- 2008. Differential effects of antipsychotic drugs on ATP-binding cassette type A1 (ABCA1) and apolipoprotein E (ApoE) gene expression in cultured cells. International Journal of Neuropsychopharmacology. 11: 259-259.
- 2007. Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. Nordic Journal of Psychiatry. 61: 501-501. doi: 10.1080/08039480701714778
- 2006. Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs. BMC Neuroscience. 7. Published 2006-10-20. doi: 10.1186/1471-2202-7-69
- 2006. Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neuroscience Letters. 395: 185-190.
- 2006. SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: Relevance for metabolic side-effects? Molecular and Cellular Biochemistry. 289: 167-173. doi: 10.1007/s11010-006-9160-4
- 2006. Antipsychotic and antidepressive drugs regulate the expression of apolipoprotein E. Nordic Journal of Psychiatry. 60: 338-338.
- 2005. Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 5: 298-304.
Reports and theses
- 2007. Lipogenic effects of antipsychotic drugs in cultured cells and in rat. 87 pages.
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