Rebecca Jane Cox Brokstad's picture
Rebecca Jane Cox
Brokstad
Professor
Visit Address: 
Haukeland universitetssykehus, Laboratoriebygget
5021 Bergen
Postal Address: 
Postboks 7804
5021 Bergen
Phone: 
+47 55 97 46 68
+47 452 42 974
E-mail: 
Rebecca.Cox@k2.uib.no
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Journal articles
  • Krammer, Florian; Albrecht, Randy A.; Tan, Gene S.; Margine, Irina; Hai, Rong; Schmolke, Mirco; Runstadler, Jonathan; Andrews, Sarah F.; Wilson, Patrick C.; Cox, Rebecca Jane; Treanor, John J.; Garcia-Sastre, Adolfo; Palese, Peter. 2014. Divergent H7 immunogens offer protection from H7N9 virus challenge. Journal of Virology. 88: 3976-3985. doi: 10.1128/JVI.03095-13
  • Mann, Alex; Noulin, Nicolas; Catchpole, Andrew; Stittelaar, Koert J.; De Waal, Leon; Veldhuis Kroeze, Edwin J.B.; Hinchcliffe, Michael; Smith, Alan; Montomoli, Emanuele; Piccirella, Simona; Osterhaus, Albert D.M. E.; Knight, Alastair; Oxford, John S.; Lapini, Giulia; Cox, Rebecca Jane; Lambkin-Williams, Rob. 2014. Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge. PLoS ONE. 9. doi: 10.1371/journal.pone.0093761
  • Olberg, Henning Kristian; Cox, Rebecca Jane; Nøstbakken, Jane Kristin; Aarseth, Jan Harald; Vedeler, Christian A.; Myhr, Kjell-Morten. 2014. Immunotherapies influence the influenza vaccination response in multiple sclerosis patients: An explorative study. Multiple Sclerosis. 20: 1074-1080. doi: 10.1177/1352458513513970
  • Pedersen, Gabriel; Höschler, Katja; Solbak, Sara Marie Øie; Bredholt, Geir; Pathirana, Rishi; Afsar, Aram; Breakwell, Lucy; Nøstbakken, Jane Kristin; Raae, Arnt Johan; Brokstad, Karl Albert; Sjursen, Haakon; Zambon, Maria; Cox, Rebecca Jane. 2014. Serum IgG titres, but not avidity, correlates with neutralizing antibody response after H5N1 vaccination. Vaccine. 32: 4550-4557. doi: 10.1016/j.vaccine.2014.06.009
  • Skrede, Steinar; Steinsland, Hans; Sommerfelt, Halvor; Aase, Audun; Brandtzæg, Per; Langeland, Nina; Cox, Rebecca Jane; Sævik, Marianne; Wallevik, Marita; Skutlaberg, Dag Harald; Tellevik, Marit Gjerde; Sack, David A; Nataro, James Paul; Guttormsen, Anne Berit. 2014. Experimental infection of healthy volunteers with enterotoxigenic Escherichia coli wild-type strain TW10598 in a hospital ward. BMC Infectious Diseases. 14. 9 pages. doi: 10.1186/1471-2334-14-482
  • Bredholt, Geir; Pedersen, Gabriel; Pathirana, Rishi; Akselsen, Per Espen; Cox, Rebecca Jane. 2013. A(H1N1)pdm09 Vaccination of Healthcare Workers: Improved Immune Responses in Low Responders Following Revaccination Reply. Journal of Infectious Diseases. 207: 1186-1188. doi: 10.1093/infdis/jit014
  • Cox, Rebecca Jane. 2013. Correlates of protection to influenza virus, where do we go from here? Human Vaccines & Immunotherapeutics. 9: 405-408. doi: 10.4161/hv.22908
  • Jul-Larsen, Åsne; Madhun, Abdullah Sami; Brokstad, Karl Albert; Montomoli, Emanuele; Yusibov, Vidadi; Cox, Rebecca Jane. 2012. The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants. Human Vaccines & Immunotherapeutics. 8: 653-661. doi: 10.4161/hv.19503
  • Pathirana, Rishi; Bredholt, Geir; Akselsen, Per Espen; Pedersen, Gabriel; Cox, Rebecca Jane. 2012. A(H1N1)pdm09 Vaccination of Health Care Workers: Improved Immune Responses in Low Responders Following Revaccination. Journal of Infectious Diseases. 206: 1660-1669. doi: 10.1093/infdis/jis589
  • Pedersen, Gabriel; Cox, Rebecca Jane. 2012. The mucosal vaccine quandary Intranasal vs. sublingual immunization against influenza. Human Vaccines & Immunotherapeutics. 8: 690-694. doi: 10.4161/hv.19568
  • Pedersen, Gabriel; Madhun, Abdullah Sami; Breakwell, Lucy; Höschler, Katja; Sjursen, Haakon; Pathirana, Rishi; Goudsmit, Jaap; Cox, Rebecca Jane. 2012. T-helper 1 cells elicited by H5N1 vaccination predict seroprotection. Journal of Infectious Diseases. 206: 158-166. doi: 10.1093/infdis/jis330
  • Simonsen, Kristian Anton; Hunskaar, Steinar; Wensaas, Knut-Arne; Rørtveit, Sverre; Cox, Rebecca Jane; Njølstad, Gro; Rørtveit, Guri. 2012. Influenza-like illness in general practice in Norway: clinical course and attitudes towards vaccination and preventive measures during the 2009 pandemic. Family Practice. 29: 139-146. Published 2011-09-05. doi: 10.1093/fampra/cmr064
  • Svindland, Signe; Jul-Larsen, Åsne; Pathirana, Rishi; Andersen, Solveig; Montomoli, Emanuele; Jabbal-Gill, Inder; Cox, Rebecca Jane; Cox, RJ. 2012. The mucosal and systemic immune responses elicited by a chitosan-adjuvanted intranasal influenza H5N1 vaccine. Influenza and Other Respiratory Viruses. 6: 90-100. doi: 10.1111/j.1750-2659.2011.00271.x
  • Cox, Rebecca Jane; Pedersen, Gabriel; Madhun, Abdullah Sami; Svindland, Signe; Sævik, Marianne; Breakwell, Lucy; Höschler, Katja; Willemsen, Marieke; Campitelli, Laura; Nøstbakken, Jane Kristin; Weverling, Gerrit Jan; Klap, Jaco; McCullough, Kenneth C; Zambon, Maria; Kompier, Ronald; Sjursen, Haakon. 2011. Evaluation of a virosomal H5N1 vaccine formulated with Matrix M (TM) adjuvant in a phase I clinical trial. Vaccine. 29: 8049-8059. doi: 10.1016/j.vaccine.2011.08.042
  • Gjeraker, Ingrid Hjetland; Pedersen, Gabriel; Svindland, Signe; Bredholt, Geir; Cox, Rebecca Jane. 2011. Comparison of Different Routes of Administration for Influenza Vaccines in a Murine Model. Scandinavian Journal of Immunology. 73: 351-351.
  • Madhun, Abdullah Sami; Haaheim, Lars Reinhardt; Nøstbakken, Jane Kristin; Ebensen, Thomas; Chichester, Jesseca; Yusibov, Vidadi; Guzman, Carlos A; Cox, Rebecca Jane. 2011. Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4(+) cells and strong mucosal and systemic antibody responses in mice. Vaccine. 29: 4973-4982. doi: 10.1016/j.vaccine.2011.04.094
  • Pedersen, Gabriel; Cox, Rebecca Jane. 2011. Influenza Specific T-Cell Responses Predict Later Neutralizing Antibody Titres in a Phase 1 Clinical Trial of a Virosomal H5N1 Vaccine Adjuvanted with Matrix-M. Scandinavian Journal of Immunology. 73: 355-355.
  • Pedersen, Gabriel; Ebensen, Thomas; Gjeraker, Ingrid Hjetland; Svindland, Signe; Bredholt, Geir; Guzman, Carlos A; Cox, Rebecca Jane. 2011. Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP. PLoS ONE. 6. 12 pages. doi: 10.1371/journal.pone.0026973
  • Pedersen, Gabriel; Halstensen, Alfred; Sjursen, Haakon; Næss, Are; Kristoffersen, Einar Klæboe; Cox, Rebecca Jane. 2011. Pandemic Influenza Vaccination Elicits Influenza-Specific CD4(+) Th1-cell Responses in Hypogammaglobulinaemic Patients: Four case reports. Scandinavian Journal of Immunology. 74: 210-218. doi: 10.1111/j.1365-3083.2011.02561.x
  • Pedersen, Gabriel; Halstensen, Alfred; Sjursen, Haakon; Næss, Are; Kristoffersen, Einar Klæboe; Cox, Rebecca Jane. 2011. Pandemic influenza vaccination of hypogammaglobulinemic patients induces normal or elevated influenza-specific CD4+Th1-cell responses. Influenza and Other Respiratory Viruses. 5: 376-379.
  • Pedersen, Gabriel; Major, Diane; Roseby, Sarah; Wood, John; Madhun, Abdullah Sami; Cox, Rebecca Jane. 2011. Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model. Influenza and Other Respiratory Viruses. 5: 426-437. doi: 10.1111/j.1750-2659.2011.00256.x
  • Wood, John; Schild, Geoffery; Cox, Rebecca Jane. 2011. Lars R. Haaheim PhD (1945-2011) Obituary. Influenza and Other Respiratory Viruses. 5: 297-298. doi: 10.1111/j.1750-2659.2011.00281.x
  • Madhun, Abdullah Sami; Akselsen, Per Espen; Sjursen, Haakon; Pedersen, Gabriel; Svindland, Signe; Nøstbakken, Jane Kristin; Nilsen, Mona Vibece; Mohn, Kristin Greve-Isdahl; Jul-Larsen, Åsne; Smith, Ingrid; Major, Diane; Wood, John; Cox, Rebecca Jane. 2010. An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers. Vaccine. 29: 266-273. doi: 10.1016/j.vaccine.2010.10.038
  • Cox, Rebecca Jane; Madhun, Abdullah Sami; Hauge, Solveig; Sjursen, Haakon; Major, Diane; Kuhne, Mirjam; Höschler, Katja; Saville, Melanie; Vogel, Frederick R.; Barclay, Wendy; Donatelli, Isabella; Zambon, Maria; Wood, John; Haaheim, Lars Reinhardt. 2009. A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine. Vaccine. 27: 1889-1897. doi: 10.1016/j.vaccine.2009.01.116
  • Cox, Rebecca Jane; Major, Diane; Hauge, Solveig; Madhun, Abdullah Sami; Brokstad, Karl Albert; Kuhne, Mirjam; Smith, Jon; Vogel, Frederick R.; Zambon, Maria; Haaheim, Lars Reinhardt; Wood, John. 2009. A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models. Influenza and Other Respiratory Viruses. 3: 107-117. doi: 10.1111/j.1750-2659.2009.00082.x
  • Haaheim, Lars Reinhardt; Madhun, Abdullah Sami; Cox, Rebecca Jane. 2009. Pandemic influenza vaccines - the challenges. Viruses. 1: 1089-1109. doi: 10.3390/v1031089
  • Hauge, Solveig; Madhun, Abdullah Sami; Brokstad, Karl Albert; Haaheim, Lars Reinhardt; Cox, Rebecca Jane; Zambon, M; Wood, J; Haaheim, LR; Cox, RJ. 2009. The Immunogenicity of a Cell-derived H7N1 Split Influenza Virion Vaccine in Mice. Scandinavian Journal of Immunology. 69: 576-578. doi: 10.1111/j.1365-3083.2009.02254.x
  • Hovden, Arnt-Ove; Brokstad, Karl Albert; Major, Diane; Wood, John; Haaheim, Lars Reinhardt; Cox, Rebecca Jane. 2009. A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice. Influenza and Other Respiratory Viruses. 3: 21-28. doi: 10.1111/j.1750-2659.2009.00075.x
  • Madhun, Abdullah Sami; Nilsen, Mona Vibece; Haaheim, Lars Reinhardt; Cox, Rebecca Jane. 2009. Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice. Vaccine. 27: 7367-7376. doi: 10.1016/j.vaccine.2009.09.044
  • Hauge, Solveig; Madhun, Abdullah Sami; Cox, Rebecca Jane; Brokstad, Karl Albert; Haaheim, Lars Reinhardt. 2007. A comparison of the humoral and cellular immune responses at different immunological sites after split influenza virus vaccination of mice. Scandinavian Journal of Immunology. 65: 14-21. doi: 10.1111/j.1365-3083.2006.01862.x
  • Hauge, Solveig; Madhun, Abdullah Sami; Cox, Rebecca Jane; Haaheim, Lars Reinhardt. 2007. Quality and kinetics of the antibody response in mice after three different low-dose influenza virus vaccination strategies. Clinical and Laboratory Immunology. 14: 978-983. doi: 10.1128/CVI.00033-07
  • Hovden, Arnt-Ove; Cox, Rebecca Jane; Haaheim, Lars Reinhardt. 2007. Influenza: the virus and prophylaxis with inactivated influenza vaccine in "at risk" groups, including COPD patients. The International Journal of Chronic Obstructive Pulmonary Disease. 2: 229-240.
  • Cox, Rebecca Jane; Brokstad, Karl Albert; Haaheim, Lars Reinhardt. 2006. Pandernic influenza vaccine development: time is of the essence. Expert Review of Vaccines. 5: 603-606.
  • Cox, Rebecca Jane; Brokstad, Karl Albert; Haaheim, Lars Reinhardt. 2006. Pandemic influenza vaccine development: time is of the essence. Expert Review of Vaccines. doi: 10.1586/14760584.5.5.603
  • Cox, Rebecca Jane; Haaheim, Lars Reinhardt; Eriksson, Jens Christian; Madhun, Abdullah Sami; Brokstad, Karl Albert. 2006. The humoral and cellular responses induced locally and systematically after parenteral influenza vaccination in man. Vaccine. 24: 6577-6580.
  • Cox, Rebecca Jane; Hovden, Arnt-Ove; Brokstad, Karl Albert; Szyszko, Ewa Alicja; Madhun, Abdullah Sami; Haaheim, Lars Reinhardt. 2006. The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice. Vaccine. 24: 6585-6587. doi: 10.1016/j.vaccine.2006.05.040
  • Szyszko, Ewa Alicja; Brokstad, Karl Albert; Cox, Rebecca Jane; Hovden, Arnt-Ove; Madhun, Abdullah Sami; Haaheim, Lars Reinhardt. 2006. Impact of influenza vaccine formulation with a detailed analysis of the cytokine response. Scandinavian Journal of Immunology. 64: 467-475. doi: 10.1111/j.1365-3083.2006.01805.x
  • Hovden, Arnt-Ove; Cox, Rebecca Jane; Haaheim, Lars Reinhardt. 2005. Whole influenza virus vaccine is more immunogenic than split influenza virus vaccine and induces primarily an IgG2a response in BALB/c mice. Scandinavian Journal of Immunology. 62: 36-44.
  • Hovden, Arnt-Ove; Cox, Rebecca Jane; Madhun, Abdullah Sami; Haaheim, Lars Reinhardt. 2005. Two doses of parenterally administered split influenza virus vaccine elicited high serum IgG concentrations which effectively limited viral shedding upon challenge in mice. Scandinavian Journal of Immunology. 62: 342-352.
  • Cox, Rebecca Jane; Brokstad, Karl; Ogra, Pearay. 2004. Influenza virus: Immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines. Scandinavian Journal of Immunology. 59: 1-15.
  • Brokstad, Karl Albert; Eriksson, Jens-Christian; Brokstad, Rebecca Jane Cox; Tynning, Turid; Olofsson, Jan; Jonsson, Roland; Davidsson, Åke. 2002. Parenteral vaccination against influenza does not induce a local antigen-specific immune response in the nasal mucosa. Journal of Infectious Diseases. 185: 878-884.
  • Cox, Rebecca Jane; Mykkeltvedt, E; Robertson, J; Haaheim, Lars Reinhardt. 2002. Non-lethal viral challenge of influenza haemagglutinin and nucleoprotein DNA vaccinated mice results in reduced viral replication. Scandinavian Journal of Immunology. 55: 14-23.
  • Brokstad, Karl Albert; Brokstad, Rebecca Jane Cox; Eriksson, Jens-Christian; Olofsson, Jan; Jonsson, Roland; Davidsson, Åke. 2001. High prevalence of influenza specific antibody secreting cells in nasal mucosa. Scandinavian Journal of Immunology. 54: 243-247.
  • Brokstad, Rebecca Jane Cox; Mykkelstveit, Eva; Robertson, James; Haaheim, Lars Reinhardt. 2001. Non-lethal viral challenge of influenza haemagglutinin and nucleoprotein DNA vaccinated mice results in reduced viral replication. Scandinavian Journal of Immunology. 55: 14-23.
  • Brokstad, Rebecca Jane Cox; Mykkelstveit, Eva; Sjursen, Haakon; Haaheim, Lars Reinhardt. 2001. The effect of zanamivir treatment on the early immune response to influenza vaccination. Vaccine. 19: 4743-4749.
Book sections
  • Cox, Rebecca Jane; Hovden, Arnt-Ove; Bragstad, Karoline; Haaland, Inger Marie; Haaheim, Lars Reinhardt. 2004. Comparison of the humoral immune response to split and whole virus vaccines in mice. Vaccines, pages 632-635. In:
    • Kawaoka, Yoshihiro. 2004. Options for the Control of Influenza V. 850 pages.
  • Hovden, Arnt-Ove; Cox, Rebecca Jane; Haaheim, Lars Reinhardt. 2004. The immune response to H7N1 whole virus vaccine in mice. Vaccines, pages 636-639. In:
    • Kawaoka, Yoshihiro. 2004. Options for the Control of Influenza V. 850 pages.
  • Madhun, Abdullah Sami; Cox, Rebecca Jane; Haaheim, Lars Reinhardt; Jonsson, Roland; Brokstad, Karl Albert. 2004. The kinetics of the systemic and local immune response to parenteral influenza vaccination. International Series 1263, pages 515-518. In:
    • Kawaoka, Yoshihiro. 2004. Options for the Control of Influenza V. 850 pages.
  • Brokstad, Karl Albert; Brokstad, Rebecca Jane Cox; Haaheim, Lars Reinhardt. 2003. Detection of antibodies to influenza virus in human mucosal tissues and fluids. In:
    • Brokstad, Karl Albert. 2003. Methods in Molecular Medicine focusing on Methods in Viral Immunity.

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