The majority of the CCBIO staff also holds positions and funding at Helse Bergen. Day to day administration is taken care of by the departments, enabling researchers to interact with their familiar support staff. In the establishment phase, this structure and interaction has been highly successful with excellent cooperation. The model is robust and reduces vulnerability to a minimum. It gives CCBIO common interests with the departments, thus easing interaction.

The research projects have been organized in three integrated programs (preclinical models, biomarkers, clinical studies) chaired by program coordinators. Lab space and core facilities are available for CCBIO, as is the Clinical Trials Unit at Haukeland University Hospital. The team of investigators (PIs) have formed the principal investigator group with monthly meetings to discuss administrative and scientific issues, and with updates on developments and progress. This is a platform for increased collaboration within CCBIO.

CCBIO is managed by the Director, Prof. Lars A. Akslen, and the Administrative Leader Geir Olav Løken, assisted by four finance officers (total of one position) at the departments of FMD. New offices for the CCBIO Management Group have been made available in the main hospital building (Sentralblokken, second floor).

During 2013, core staff has been recruited, such as the Administrative Leader (Geir Olav Løken), three senior laboratory managers (PhDs), nine recruitment positions (PhD positions, postdocs), and one postdoc in ethics. One postdoc in bioinformatics will be added to the staff. In addition, one adjunct professor (health economy) at 20% has been recruited (Prof. John Cairns, London School of Hygiene and Tropical Medicine), and more external 20% positions are in the  recruitment process as part of international networking. The recruitment positions were advertised in Nature on April 25, 2013, in combination with comments on CCBIO in Spotlight on Norway: Healthy outlook for Norwegian life science.