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Fluorescence- and electron microscopy

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Is used to identify changes in protein levels, localization and modification which are associated with cellular processes. It is also used to identify the chemical structure of unknown compounds.

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DNA and RNA analysis (PCR, q-PCR, microarray, chromatin immuno-precipitation) as well as in vitro studies on purified proteins (immuno- blotting, kinetic analysis, spectroscopy, surface plasmon resonance) are extensively applied.

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We use ODE and stochastic simulations to assist our understanding of cellular signaling and how the kinetic properties of proteins determine the dynamics of cellular processes.