Selected publications

Created 28.01.2009 - 10.01
Last updated 19.12.2012 - 11.39

 

  1. Huseby S, Gausdal, Keen TJ, Kjærland E, Krakstad C, Myhren L, Brønstad K, Kunick C, Schwede F, Genieser H-G, Kleppe R, Døskeland SO. Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death Disease. 2011. In print

  2. The 14-3-3 proteins in regulation of cellular metabolism. Kleppe R, Martinez A, Døskeland SO, Haavik J. Semin Cell Dev Biol. 2011. 22(7):713-9.

  3. Kleppe R, Krakstad C, Selheim F, Kopperud R, Døskeland SO. The cAMP-dependent protein kinase pathway as therapeutic target: possibilities and pitfalls. Curr Top Med Chem. 2011. 11(11):1393-405.

  4. Dao KK, Pey AL, Gjerde AU, Teigen K, Byeon IJ, Døskeland SO, Gronenborn AM, Martinez A. The regulatory subunit of PKA-I remains partially structured and undergoes aggregation upon thermal denaturation β-aggregation upon thermal denaturation. PLoS One. 2011. 6(3):e17602.

  5. Herfindal L, Myhren L, Kleppe R, Krakstad C, Selheim F, Jokela J, Sivonen K, Døskeland SO. Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1. Mol Pharm. 2011. 8(2):360-7

  6. Oftedal L, Selheim F, Wahlsten M, Sivonen K, Døskeland SO, Herfindal L. Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes. Mar Drugs. 2010. 8(10):2659-72.

  7. Jensen BO, Kleppe R, Kopperud R, Nygaard G, Døskeland SO, Holmsen H, Selheim F. Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change. Platelets. 2011. 22(1):7-18.

  8. Oftedal L, Skjærven KH, Coyne RT, Edvardsen B, Rohrlack T, Skulberg OM, Døskeland SO, Herfindal L. The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity. J Ind Microbiol Biotechnol. 2011. 38(4):489-501.

  9. Madsen L, Pedersen LM, Lillefosse HH, Fjaere E, Bronstad I, Hao Q, Petersen RK, Hallenborg P, Ma T, De Matteis R, Araujo P, Mercader J, Bonet ML, Hansen JB, Cannon B, Nedergaard J, Wang J, Cinti S, Voshol P, Døskeland SO, Kristiansen K.UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity.  PLoS One. 2010. 5(6):e11391.

  10. Jokela J, Herfindal L, Wahlsten M, Permi P, Selheim F, Vasconçelos V, Døskeland SO, Sivonen K. A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins. Chembiochem. 2010. 11(11):1594-9.

  11. Byeon IJ, Dao KK, Jung J, Keen J, Leiros I, Døskeland SO, Martinez A, Gronenborn AM. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. J Biol Chem. 2010. 285(18):14062-70.

  12. Prestegard SK, Oftedal L, Coyne RT, Nygaard G, Skjaerven KH, Knutsen G, Døskeland SO, Herfindal L. Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity. Mar Drugs. 2009. 7(4):605-23.

  13. Herfindal L, Kasprzykowski F, Schwede F, Łankiewicz L, Fladmark KE, Łukomska J, Wahlsten M, Sivonen K, Grzonka Z, Jastorff B, Døskeland SO. Acyloxymethyl esterification of nodularin-R and microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. J Med Chem. 2009. 52(18):5758-62.

  14. Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes. Madsen L, Petersen RK, Steffensen KR, Pedersen LM, Hallenborg P, Ma T, Frøyland L, Døskeland SO, Gustafsson JA, Kristiansen K. J Biol Chem. 2008. 283(33):22723-36.

  15. Petersen RK, Madsen L, Pedersen LM, Hallenborg P, Hagland H, Viste K, Døskeland SO, Kristiansen K. Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes. Mol Cell Biol. 2008. 28(11):3804-16.

  16. Poppe H, Rybalkin SD, Rehmann H, Hinds TR, Tang XB, Christensen AE, Schwede F, Genieser HG, Bos JL, Doskeland SO, Beavo JA, Butt E. Cyclic nucleotide analogs as probes of signaling pathways. Nat Methods. 2008. 5(4):277-8.

  17. Serres, M.H., Fladmark, K.E., and Døskeland, S.O. (2000) An ultrasensitive competitive binding assay for the detection of protein phosphatase directed toxins. Toxicon.38, 347-360.

  18. Schwede, F., Brustugun, O.T., Zorn-Kruppa, M., Døskeland, S.O., and Jastorff, B. (2000) Membrane permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells. Bioorg. Med. Chem. Lett. 10, 571-573.

  19. Seite P, Ruchaud S, Hillion J, Gendron MC, Bruland O, Segal-Bendirdjian E, Doskeland SO, Lillehaug JR, Lanotte M (2000). Ectopic expression of Bcl-2 switches over nuclear signalling for cAMP-inducd apoptosis to granulocytic differentiation. Cell Death Diff. 2000 7, 1081-1089.

  20. Schwede, F., Christensen, A., Liauw, S., Hippe, T., Kopperud, R., Jastorff, B., and Døskeland, S.O. (2000). 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochemistry  39, 8803-8812.

  21. Sandal, T., Ahlgren, R., Lillehaug, J., and Døskeland, S.O. (2001). Establishment of okadaic acid resistant cell clones using a cDNA expression library. Cell Death Diff  8, 754-66.

  22. Mankiewicz J, Tarczynska M, Fladmark KE, Døskeland SO, Walter Z, Zalewski M. (2001) Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environ Toxicol. 16, 225-33.

  23. Mankiewicz J, Walter Z, Tarczynska M, Zalewski M, Fladmark KE, Døskeland SO. (2001)  Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. Int J Occup Med Environ Health. 13, 335-44.

  24. Fladmark KE, Brustugun OT, Mellgren G, Krakstad C, Boe R, Vintermyr OK, Schulman H, Døskeland SO. (2002)  Ca2+/calmodulin-dependent protein kinase II is required for microcystin-induced apoptosis. J. Biol. Chem. 277, 2804 - 2811

  25. Kopperud, R., Christensen, A., Viste, K., Kjærland, E., Kleivdal, H., and Døskeland, S.O. (2002) Formation of inactive cAMP-saturated holoenzyme of cAMP-dependent protein kinase under physiological conditions. J. Biol. Chem. 277, 13443-8.

  26. Gjertsen BT, Oyan AM, Marzolf B, Hovland R, Gausdal G, Døskeland SO, Dimitrov K, Golden A, Kalland KH, Hood L, Bruserud O. (2002) Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses. J Hematother Stem Cell Res. 11, 469-81.