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Legemiddelutvikling og evaluering
Prosjekttittel: Combining parabens in new ways to achieve better activity at reduced concentrations.
Hensikt/problemstilling:: Parabens are among the most widely used preservatives in medicines and allied products. Certain health issues, including hormone-like effects have been reported for parabens. The study aims to combine parabens in novel ways to achieve better activity, such that lower total concentrations can be used.
Kontaktperson HF: Colin Charnock, Colin.Charnock@hf.hio.no
Prosjektmedarbeidere: Tore Finsrud, HiO; Norges Apotekerforening
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Prosjekttittel: Testing of novel derivatives of metronidazole.
Hensikt/problemstilling: Metronidazole is an important antibiotic in the treatment of infections with anaerobic bacteria and protozoa. The chemical structure of metronidazole has been modified in various ways to produce a series of novel derivatives; these are currently being screened for activity.
Kontaktperson HF: Colin Charnock, Colin.Charnock@hf.hio.no
Prosjektmedarbeidere: Professor Jo Klaveness, UiO (prosjektleder)
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Prosjekttittel: Synthesis and antibacterial activity of agelasine and its analogues.
Hensikt/problemstilling: Agelasines are 7,9-dialkylpurinium salts which show activity against a number of bacterial species including Mycobacterium species. We are currently testing a number of analogues for antibacterial activity.
Kontaktperson HF: Colin Charnock, Colin.Charnock@hf.hio.no
Prosjektmedarbeidere: Professor Lise-Lotte Gundersen, UiO (prosjektleder)
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Prosjekttittel: Development of new tattooing colourants which satisfy the requirements of the European Commission.
Hensikt/problemstilling Tattooing colourants can be heavily contaminated with bacteria. However, new proposals from the Europoean Commission will suggest that colourants in the future be produced without preservatives. We are currently testing a new range of colourants which use an ion exchange mechanism (instead of preservatives) as antimicrobial factor.
Kontaktperson på HF: Colin Charnock, Colin.Charnock@hf.hio.no
Prosjektmedarbeidere: Ralf Michel, Deep Colours GmbH.
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Prosjekttittel: Bruk av antiepileptika hos pasienter ved spesialsykehuset for
epilepsi (SSE)
Hensikt/problemstilling: Hvordan brukes antiepileptika hos inneliggende
pasienter på et spesialsykehus, mht. bruk av nye preparater,
comorbiditet og kombinasjonsbehandling, i forhold til forbruksstatistikk
og terapianbefaling?
Kontaktperson HF: Cecilie Johannessen Landmark, Cecilie.Landmark@hf.hio.no Prosjektmedarbeidere: Elisif Rytter og Svein I. Johannessen, SSE
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Prosjekttittel: Molekylære mekanismer for effekt av antiepileptika
Hensikt/problemstilling:: Antiepileptika brukes i dag mot en rekke andre lidelser
enn epilepsi, f.eks. bipolare lidelser, migrene, smerter. Hvilke
mekanismer er involvert i effekten av antiepilepsika ved disse lidelsene?
Kontaktperson HF: Cecilie Johannessen Landmark, Cecilie.Landmark@hf.hio.no
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