Håkon Reikvam's picture
Håkon
Reikvam
Associate Professor
Visit Address: 
Haukeland universitetssykehus, Laboratoriebygget
5021 Bergen
Postal Address: 
Postboks 7804
5021 Bergen
Phone: 
+47 55 58 54 08
E-mail: 
Hakon.Reikvam@k2.uib.no
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Journal articles
  • Haaland, Ingvild; Opsahl, Jill Anette; Berven, Frode; Reikvam, Håkon; Fredly, Hanne Kristin; Haugse, Ragnhild; Thiede, Bernd; McCormack, Emmet; Lain, Sonia; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2014. Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia. Molecular Cancer. 13. doi: 10.1186/1476-4598-13-116
  • Nepstad, Ina; Reikvam, Håkon; Strandenes, Geir; Hess, John R.; Apelseth, Torunn Oveland; Hervig, Tor. 2014. Comparison of in vitro responses to fresh whole blood and reconstituted whole blood after collagen stimulation. Blood Transfusion. 12: 50-55. doi: 10.2450/2013.0303-12
  • Reikvam, Håkon; Brenner, Annette; Nepstad, Ina; Sulen, Andre; Bruserud, Øystein. 2014. Heat shock protein 70 - the next chaperone to target in the treatment of human acute myelogenous leukemia? Expert opinion on therapeutic targets. 18: 929-944. doi: 10.1517/14728222.2014.924925
  • Reikvam, Håkon; Forthun, Rakel Brendsdal; Brenner, Annette; Ersvær, Elisabeth; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2014. Heat shock protein 90 – a potential target in the treatment of human acute myelogenous leukemia. Advances in cancer drug targets. 2: 3-53. doi: 10.2174/9781608059386114020003
  • Reikvam, Håkon; Tamburini, Jerome; Skrede, Silje; Holdhus, Rita; Poulain, Laury; Ersvær, Elisabeth; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2014. Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect. British Journal of Haematology. 164: 200-211. doi: 10.1111/bjh.12611
  • Bredholt, Therese; Ersvær, Elisabeth; Erikstein, Bjarte Skoe; Sulen, Andre; Reikvam, Håkon; Aarstad, Hans Jørgen; Johannessen, Anne Chr.; Vintermyr, Olav Karsten; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2013. Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine. BMC Pharmacology & Toxicolog. 14. 13 pages. doi: 10.1186/2050-6511-14-35
  • Bruserud, Øystein; Liseth, Knut; Stamnesfet, Siren; Cacic, Daniel Limi; Melve, Guro Kristin; Kristoffersen, Einar Klæboe; Hervig, Tor; Reikvam, Håkon. 2013. Hyperleukocytosis and leukocytapheresis in acute leukaemias: experience from a single centre and review of the literature of leukocytapheresis in acute myeloid leukaemia. Transfusion Medicine. 23: 397-406. doi: 10.1111/tme.12067
  • Lied, Gülen Arslan; Chen, Jian; Reikvam, Håkon. 2013. Forskningsveiledning - en av de essensielle faktorene på «veien til doktorgrad». Uniped. 36: 45-54. doi: 10.3402/uniped.v36i4.23143
  • Mosevoll, Knut Anders; Akkøk, Cigdem Ahaein; Hervig, Tor; Melve, Guro Kristin; Bruserud, Øystein; Reikvam, Håkon. 2013. Stem cell mobilization and harvesting by leukapheresis alters systemic cytokine levels in patients with multiple myeloma. Cytotherapy. 15: 850-860. doi: 10.1016/j.jcyt.2013.02.008
  • Reikvam, Håkon; Fredly, Hanne Kristin; Kittang, Astrid Marta Olsnes; Bruserud, Øystein. 2013. The possible diagnostic and prognostic use of systemic chemokine profiles in clinical medicine-the experience in acute myeloid leukemia from disease development and diagnosis via conventional chemotherapy to allogeneic stem cell transplantation. Toxins. 5: 336-362. doi: 10.3390/toxins5020336
  • Reikvam, Håkon; Kittang, Astrid Marta Olsnes; Melve, Guro Kristin; Mosevoll, Knut Anders; Bentsen, Pål Tore; Ersvær, Elisabeth; Gjertsen, Bjørn Tore; Bruserud, Øystein. 2013. Targeted anti-leukemic therapy as disease-stabilizing treatment for acute myeloid leukemia relapse after allogeneic stem cell transplantation: will it be possible to combine these strategies with retransplantation or donor lymphocyte infusions? Current Cancer Drug Targets. 13: 30-47. doi: 10.2174/1568009611309010030
  • Reikvam, Håkon; Nepstad, Ina; Bruserud, Øystein; Hatfield, Kimberley Joanne. 2013. Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells. OncoTarget. 4: 830-843.
  • Reikvam, Håkon; Nepstad, Ina; Sulen, Andre; Gjertsen, Bjørn Tore; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2013. Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors. Expert Opinion on Investigational Drugs. 22: 551-563. doi: 10.1517/13543784.2013.791280
  • Reikvam, Håkon; Nepstad, Ina; Tamburini, Jerome. 2013. Predicting effects of kinase inhibitor in therapy for myeloid malignancies - the challenges in capturing disease heterogeneity. Expert Opinion on Investigational Drugs. 22: 1365-1370. doi: 10.1517/13543784.2013.841137
  • Reikvam, Håkon; Øyan, Anne Margrete; Kalland, Karl-Henning; Hovland, Randi; Hatfield, Kimberley Joanne; Bruserud, Øystein. 2013. Differences in proliferative capacity of primary human acute myelogenous leukaemia cells are associated with altered gene expression profiles and can be used for subclassification of patients. Cell Proliferation. 46: 554-562. doi: 10.1111/cpr.12057
  • Bruserud, Øystein; Reikvam, Håkon; Kittang, Astrid Marta Olsnes; Ahmed, Aymen B; Tvedt, Tor Henrik Anderson; Sjo, Malvin; Hatfield, Kimberley Joanne. 2012. High-dose etoposide in allogeneic stem cell transplantation. Cancer Chemotherapy and Pharmacology. 70: 765-782. doi: 10.1007/s00280-012-1990-z
  • Fredly, Hanne Kristin; Reikvam, Håkon; Gjertsen, Bjørn Tore; Bruserud, Øystein. 2012. Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: Serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment. American Journal of Hematology. 87: 368-376. doi: 10.1002/ajh.23116
  • Hatfield, Kimberley Joanne; Evensen, Lasse; Reikvam, Håkon; Lorens, James; Bruserud, Øystein. 2012. Soluble mediators released by acute myeloid leukemia cells increase capillary-like networks. European Journal of Haematology. 89: 478-490. doi: 10.1111/ejh.12016
  • Reikvam, Anne-Grete; Hustad, Simon Steinar; Reikvam, Håkon; Apelseth, Torunn Oveland; Nepstad, Ina; Hervig, Tor. 2012. The effects of selective serotonin reuptake inhibitors on platelet function in whole blood and platelet concentrates. Platelets. 23: 299-308. doi: 10.3109/09537104.2011.618852
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Ersvær, Elisabeth; Hovland, Randi; Skavland, Jørn; Gjertsen, Bjørn Tore; Petersen, Kjell; Bruserud, Øystein. 2012. Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status - consequences and potentials for pharmacological intervention. British Journal of Haematology. 156: 468-480. doi: 10.1111/j.1365-2141.2011.08960.x
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Fredly, Hanne Kristin; Nepstad, Ina; Mosevoll, Knut Anders; Bruserud, Øystein. 2012. The angioregulatory cytokine network in human acute myeloid leukemia - from leukemogenesis via remission induction to stem cell transplantation. European Cytokine Network. 23: 140-153. doi: 10.1684/ecn.2012.0322
  • Reikvam, Håkon; Mosevoll, Knut Anders; Melve, Guro Kristin; Günther, Clara-Cecilie; Sjo, Malvin; Bentsen, Pål Tore; Bruserud, Øystein. 2012. The pretransplantation serum cytokine profile in allogeneic stem cell recipients differs from healthy individuals, and various profiles are associated with different risks of posttransplantation complications. Biology of blood and marrow transplantation. 18: 190-199. doi: 10.1016/j.bbmt.2011.10.007
  • Reikvam, Håkon; Power, Øystein Alexander; Høvding, Pål; Lindemann, Paul Christoffer; Sjursen, Haakon. 2012. En mann med smerter etter kneoperasjon. Tidsskrift for Den norske legeforening. 132. 1472-1474.
  • Reikvam, Håkon; Tiu, Ramon V. 2012. Venous thromboembolism in patients with essential thrombocythemia and polycythemia vera. Leukemia. 26: 563-571. doi: 10.1038/leu.2011.314
  • Tsykunova, Galina; Reikvam, Håkon; Ahmed, Aymen B; Nepstad, Ina; Gjertsen, Bjørn Tore; Bruserud, Øystein. 2012. Targeting of polo-like kinases and their cross talk with Aurora kinases - possible therapeutic strategies in human acute myeloid leukemia? Expert Opinion on Investigational Drugs. 21: 587-603. doi: 10.1517/13543784.2012.668525
  • Tsykunova, Galina; Reikvam, Håkon; Hovland, Randi; Bruserud, Øystein. 2012. The surface molecule signature of primary human acute myeloid leukemia (AML) cells is highly associated with NPM1 mutation status. Leukemia. 26: 557-559. doi: 10.1038/leu.2011.243
  • Apelseth, Torunn Oveland; Hervig, Tor; Wentzel-Larsen, Tore; Petersen, Kjell; Reikvam, Håkon; Bruserud, Øystein. 2011. A prospective observational study of the effect of platelet transfusions on levels of platelet-derived cytokines, chemokines and interleukins in acute leukaemia patients with severe chemotherapy-induced cytopenia. European Cytokine Network. 22: 52-62. doi: 10.1684/ecn.2011.0271
  • Bruserud, Øystein; Hatfield, Kimberley Joanne; Reikvam, Håkon. 2011. Heat shock protein 90 (HSP90) inhibition in acute myeloid leukemia-Targeting of disease heterogeneity through direct and indirect antileukemic effects. Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. 35: 1156-1158. doi: 10.1016/j.leukres.2011.06.005
  • Ersvær, Elisabeth; Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein. 2011. Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies. Bone Marrow Research. 2011.
  • Jørgensen, Katarina Mariann; Hjelle, Sigrun Margrethe; Øye, Ola Kristoffer; Puntervoll, Pål; Reikvam, Håkon; Skavland, Jørn; Anderssen, Endre; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2011. Untangling the intracellular signalling network in cancer - a strategy for data integration in acute myeloid leukemia. Journal of Proteomics. 74: 269-281. doi: 10.1016/j.jprot.2010.11.003
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Kittang, Astrid Marta Olsnes; Hovland, Randi; Bruserud, Øystein. 2011. Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications. Journal of Biomedicine and Biotechnology. 23 pages. doi: 10.1155/2011/104631
  • Reikvam, Håkon; van de Watering, Leo; Prowse, Chris V.; Devine, Dana; Heddle, Nancy M.; Hervig, Tor. 2011. Evaluation of noninvasive methods for the estimation of haemoglobin content in red blood cell concentrates. Transfusion Medicine. 21: 145-149. doi: 10.1111/j.1365-3148.2010.01059.x
  • Bruserud, Øystein; Reikvam, Håkon. 2010. Heat shock protein 90 (HSP90) inhibition-From experimental to clinical studies. Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. 34: 1422-1423. doi: 10.1016/j.leukres.2010.06.022
  • Bruserud, Øystein; Reikvam, Håkon. 2010. Therapeutic targeting of NF-kappa B in myelodysplastic syndromes and acute myeloid leukaemia - the biological heterogeneity. Expert opinion on therapeutic targets. 14: 1139-1142. doi: 10.1517/14728222.2010.525021
  • Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein. 2010. The Crosstalk Between the Matrix Metalloprotease System and the Chemokine Network in Acute Myeloid Leukemia. Current Medicinal Chemistry. 17: 4448-4461.
  • Hjelle, Sigrun Margrethe; Forthun, Rakel Brendsdal; Haaland, Ingvild; Reikvam, Håkon; Sjøholt, Gry; Bruserud, Øystein; Gjertsen, Bjørn Tore. 2010. Clinical proteomics of myeloid leukemia. Genomu Igaku : Genome Medicine. 2. doi: 10.1186/gm162
  • Kittang, Astrid Marta Olsnes; Hatfield, Kimberley Joanne; Sand, Kristoffer Evebø; Reikvam, Håkon; Bruserud, Øystein. 2010. The Chemokine Network in Acute Myelogenous Leukemia: Molecular Mechanisms Involved in Leukemogenesis and Therapeutic Implications. Current Topics in Microbiology and Immunology. 341: 149-172. doi: 10.1007/82_2010_25
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Ersvær, Elisabeth; Ryningen, Anita; Bruserud, Øystein. 2010. PHARMACOLOGICAL TARGETING OF THE PI3K-AKT/PKB-MTOR PATHWAY ALTERS LOCAL ANGIOREGULATION IN ACUTE MYELOGENOUS LEUKEMIA. Haematologica. 95: 266-266.
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Lassalle, Philippe; Kittang, Astrid Marta Olsnes; Ersvær, Elisabeth; Bruserud, Øystein. 2010. Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release. Expert Opinion on Investigational Drugs. 19: 169-183. doi: 10.1517/13543780903485659
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Kalland, Karl-Henning; Kittang, Astrid Marta Olsnes; Bruserud, Øystein. 2010. Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. European Journal of Haematology. 84: 239-251. doi: 10.1111/j.1600-0609.2009.01382.x
  • Reikvam, Håkon; Marschner, Susanne; Apelseth, Torunn Oveland; Goodrich, Ray; Hervig, Tor. 2010. The Mirasol (R) Pathogen Reduction Technology system and quality of platelets stored in platelet additive solution. Blood Transfusion. 8: 186-192. doi: 10.2450/2010-0141-09
  • Reikvam, Håkon; Melve, Guro Kristin; Svendheim, Kjersti; Hervig, Tor. 2010. Why is potentional blood donors deferred from donation? Haematologica. 95: 738-738.
  • Reikvam, Håkon; Prowse, Chris V.; Roddie, Huw; Heddle, Nancy M.; Hervig, Tor. 2010. A pilot study of the possibility and the feasibility of haemoglobin dosing with red blood cells transfusion. Vox Sanguinis. 99: 71-76. doi: 10.1111/j.1423-0410.2010.01321.x
  • Fotland, Solveig Simmenes; Reikvam, Håkon; Hervig, Tor; Seghatchian, Jerard. 2009. Does the preoperative iron status predict transfusion requirement of orthopedic patients? Transfusion and apheresis science. 40: 213-217. doi: 10.1016/j.transci.2009.03.007
  • Reikvam, Håkon; Blom, Unni Sandaker; Kristoffersen, Einar Klæboe; Liseth, Knut; Bruserud, Øystein; Hervig, Tor. 2009. Granulocyttransfusjon. Tidsskrift for Den norske legeforening. 129: 416-419. doi: 10.4045/tidsskr.09.34313
  • Reikvam, Håkon; Ersvær, Elisabeth; Bruserud, Øystein. 2009. Heat shock protein 90-a potential target in the treatment of human acute myelogenous leukemia. Current Cancer Drug Targets. 9: 761-776.
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Olsnes, Astrid Marta; Øyan, Anne Margrete; Kalland, Karl-Henning; Bruserud, Øystein. 2009. PRIMARY HUMAN ACUTE MYELOGENOUS LEUKEMIA CELLS SHOW CONSTITUTIVE RELEASE OF SEVERAL MATRIX METALLOPROTEASES AND THEIR INHIBITORS. Haematologica. 94: 545-545.
  • Reikvam, Håkon; Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Kalland, Karl-Henning; Kittang, Astrid Marta Olsnes; Bruserud, Øystein. 2009. Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors; release profile and pharmacological modulaion. European Journal of Haematology. 84: 239-251. doi: 10.1111/j.1600-0609.2009.01382.x
  • Reikvam, Håkon; Olsnes, Astrid Marta; Gjertsen, Bjørn Tore; Ersvær, Elisabeth; Bruserud, Øystein. 2009. Nuclear Factor-kappaB Signaling: A Contributor in Leukemogenesis and a Target for Pharmacological Intervention in Human Acute Myelogenous Leukemia. Critical reviews in oncogenesis. 15: 1-41.
  • Reikvam, Håkon; Steien, Egil; Hauge, Bjarne; Liseth, Knut; Hagen, Kristin Gjerde; Størkson, Rolf; Hervig, Tor. 2009. TREATMENT OF ORBISAC DERIVED BUFFY COAT PLATELETS WITH THE MIRASOL (R) PATHOGEN REDUCTION TECHNOLOGY AND STORAGE IN ADDITIVE SOLUTION. Haematologica. 94: 284-284.
  • Reikvam, Håkon; Steien, Egil; Hauge, Bjørn; Liseth, Knut; Hagen, Kristin Gjerde; Størkson, Rolf Vilhelm; Hervig, Tor. 2009. Thrombelastography. Transfusion and apheresis science. 40: 119-123. doi: 10.1016/j.transci.2009.01.019
  • Stapnes, Camilla I; Gjertsen, Bjørn Tore; Reikvam, Håkon; Bruserud, Øystein. 2009. Targeted therapy in acute myeloid leukaemia: current status and future directions. Expert Opinion on Investigational Drugs. 18: 433-455. doi: 10.1517/14728220902787628
Reports and theses
  • Reikvam, Håkon. 2012. New therapeutic targets in human acute myeloid leukemia. University of Bergen.

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