Jørn V. Sagen's picture
Jørn V.
Sagen
Associate professor II
Visit Address: 
Haukeland universitetssykehus, Laboratoriebygget
5021 Bergen
Postal Address: 
Postboks 7804
5021 Bergen
Phone: 
+47 55 97 61 74
E-mail: 
Jorn.Sagen@k2.uib.no
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Journal articles
  • Dankel, Simon E Nitter; Degerud, Eirik Magnus Meek; Borkowski, Kamil; Fjære, Even; Midtbø, Lisa Kolden; Haugen, Christine; Solsvik, Margit; Lavigne, Ann Marie; Liaset, Bjørn; Sagen, Jørn V.; Kristiansen, Karsten; Mellgren, Gunnar; Madsen, Lise. 2014. Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. American Journal of Physiology. Endocrinology and Metabolism. 306: E210-E224. doi: 10.1152/ajpendo.00188.2013
  • Dankel, Simon E Nitter; Svärd, Jessica; Matthä, Simone; Claussnitzer, Melina; Klöting, Nora; Glunk, Viktoria; Fandalyuk, Zinayida; Grytten, Elise; Solsvik, Margit; Nielsen, Hans Jørgen; Busch, Christian; Hauner, Hans; Blüher, Matthias; Skurk, Thomas; Sagen, Jørn V.; Mellgren, Gunnar. 2014. COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity. 22: 1807-1813. doi: 10.1002/oby.20758
  • Negahdar, Maria; Aukrust, Ingvild; Molnes, Janne; Solheim, Marie Holm; Johansson, Bente Berg; Sagen, Jørn V.; Dahl-Jørgensen, Knut; Kulkarni, Rohit Rajesh; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise. 2014. GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation. Molecular and Cellular Endocrinology. 382: 55-65. doi: 10.1016/j.mce.2013.08.020
  • Chudasama, Kishan Kumar; Winnay, Jonathan; Johansson, Stefan; Claudi, Tor; König, Rainer; Haldorsen, Ingfrid S.; Johansson, Bente Berg; Woo, Ju Rang; Aarskog, Dagfinn; Sagen, Jørn V.; Kahn, C. Ronald; Molven, Anders; Njølstad, Pål Rasmus. 2013. SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling. American Journal of Human Genetics. 93: 150-157. doi: 10.1016/j.ajhg.2013.05.023
  • Fenne, Ingvild Sveinsgjerd; Helland, Thomas; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Mellgren, Gunnar; Sagen, Jørn V. 2013. Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. PLoS ONE. 8. 10 pages. doi: 10.1371/journal.pone.0070096
  • Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Madsen, Andre Greger; Bozickovic, Olivera; Johannessen, Mona; Bergsvåg, Mari; Lien, Ernst Asbjørn; Stallcup, Michael R.; Sagen, Jørn V.; Moens, Ugo; Mellgren, Gunnar. 2013. cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology. 154: 1513-1527. doi: 10.1210/en.2012-2049
  • Madsen, Arve; Bjune, Jan Inge; Mellgren, Gunnar; Sagen, Jørn V. 2013. AICAR regulates G6Pase independently of SRC-2/ROR alpha. Diabetologia. 56: S281-S281.
  • Søvik, Oddmund; Irgens, Henrik Underthun; Molnes, Janne; Sagen, Jørn V.; Bjørkhaug, Lise; Ræder, Helge; Molven, Anders; Njølstad, Pål Rasmus. 2013. Monogenetic diabetes mellitus in Norway :. Norsk Epidemiologi. 23: 55-60.
  • York, Brian; Sagen, Jørn V.; Tsimelzon, Anna; Louet, Jean Francois; Chopra, Atul R.; Reineke, Erin L.; Zhou, Suoling; Stevens, Robert D.; Wenner, Brett R.; Ilkayeva, Olga; Bain, James R.; Xu, Jianming; Hilsenbeck, Susan G.; Newgard, Christopher B.; O'Malley, Bert W. 2013. Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. Molecular Endocrinology. 27: 366-380. doi: 10.1210/me.2012-1324
  • Veum, Vivian Lohmann; Dankel, Simon E Nitter; Gjerde, Jennifer; Nielsen, Hans Jørgen; Solsvik, Margit Hildershavn; Haugen, Christine; Christensen, Bjørn Jostein; Hoang, Tuyen; Fadnes, Dag Jone Stokke; Busch, Christian; Våge, Villy; Sagen, Jørn V.; Mellgren, Gunnar. 2012. The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. International Journal of Obesity. 36: 1195-1202. doi: 10.1038/ijo.2011.240
  • York, Brian; Reineke, Erin L.; Sagen, Jørn V.; Nikolai, Bryan C.; Zhou, Suoling; Louet, Jean Francois; Chopra, Atul R.; Chen, Xian; Reed, Graham; Noebels, Jeffrey; Adesina, Adekunle M.; Yu, Hui; Wong, Lee-Jun C.; Tsimelzon, Anna; Hilsenbeck, Susan; Stevens, Robert D.; Wenner, Brett R.; Ilkayeva, Olga; Xu, Jianming; Newgard, Christopher B.; O'Malley, Bert W. 2012. Ablation of Steroid Receptor Coactivator-3 Resembles the Human CACT Metabolic Myopathy. Cell Metabolism. 15: 752-763. doi: 10.1016/j.cmet.2012.03.020
  • Sagen, Jørn V. 2011. Nuclear hormone receptors – a family of hormone dependent transcriptional regulators. Klinisk kemi i Norden. 23: 30-35.
  • Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen; Veum, Vivian Lohmann; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2010. Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS ONE. 5. 12 pages. doi: 10.1371/journal.pone.0011033
  • Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen; Veum, Vivian Lohmann; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar. 2010. From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. Endocrine journal. 57: S429-S429.
  • Dankel, Simon E Nitter; Hoang, Tuyen; Flågeng, Marianne Hauglid; Sagen, Jørn V.; Mellgren, Gunnar. 2010. cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. Biochimica et Biophysica Acta. Molecular Cell Research. 1803: 1013-1019. doi: 10.1016/j.bbamcr.2010.05.008
  • Hoang, Tuyen; Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Veum, Vivian Lohmann; Våge, Villy; Steen, Vidar Martin; Sagen, Jørn V.; Mellgren, Gunnar. 2010. Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. Endocrine reviews. 31. 1 pages.
  • York, Brian; Yu, Chundong; Sagen, Jørn V.; Liu, Zhaoliang; Nikolai, Bryan C.; Wu, Ray-Chang; Finegold, Milton; Xu, Juanming; O'Malley, Bert W. 2010. Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology. Proceedings of the National Academy of Science of the United States of America. 107: 11122-11127. doi: 10.1073/pnas.1005262107
  • Fenne, Ingvild Sveinsgjerd; Hoang, Tuyen; Hauglid, Marianne; Sagen, Jørn V.; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2008. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology. 149: 4336-4345. doi: 10.1210/en.2008-0037
  • Sagen, Jørn V.; Bjørkhaug, Lise; Molnes, Janne; Ræder, Helge; Grevle, Louise; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2008. Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. Pediatric Diabetes. 9: 442-449. doi: 10.1111/j.1399-5448.2008.00399.x
  • Søvik, Oddmund; Tansek, Mojca Zerjav; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2007. Management of neonatal and infancy-onset diabetes mellitus. Endocrine Development. 11: 94-105.
  • Raeder, Helge; Ræder, Helge; Bjorkhaug, Lise; Bjørkhaug, Lise; Johansson, Stefan; Mangseth, Kjersti; Sagen, Jørn V.; Hunting, Anne; Følling, Ivar; Johansen, Odd; Bjørgaas, Marit; Paus, Povel N.; Søvik, Oddmund; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2006. A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry. Diabetes. 55: 1899-1903. doi: 10.2337/db05-1677
  • Ræder, Helge; Johansson, Stefan; Holm, Pål I.; Haldorsen, Ingfrid S.; Mas, Eric; Sbarra, Véronique; Nermoen, Ingrid; Eide, Stig Åge; Grevle, Louise; Bjørkhaug, Lise; Sagen, Jørn V.; Aksnes, Lage; Søvik, Oddmund; Lombardo, Dominique; Molven, Anders; Njølstad, Pål Rasmus. 2006. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics. 38: 54-62. doi: 10.1038/ng1708
  • Sagen, JV; Odili, S; Bjørkhaug, L.; Zelent, D; Buettger, C; Kwagh, J; Stanley, C; Dahl-Jørgensen, Knut; de Beaufort, CE; Bell, GI; Han, Y; Grimsby, J; Taub, R; Molven, A; Søvik, Oddmund; Njølstad, PR; Matschinsky, FM. 2006. From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Diabetes. 55: 1713-1722.
  • Bjørkhaug, Lise; Johansson, Stefan; Ræder, Helge; Thorsby, PM; Undlien, DE; Søvik, Oddmund; Molven, Anders; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2005. Molekylærgenetisk diagnostikk ved diabetes mellitus. Tidsskrift for Den norske legeforening. 125: 2968-2972.
  • Gundersen, Lise Bj.; Johansson, Stefan; Ræder, Helge; Undlien, Dag E.; Molven, Anders; Søvik, Oddmund; Thorsby, Per; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2005. Molekylærgenetisk diagnostikk ved diabetes mellitus. Tidsskrift for Den norske legeforening. 125: 2968-2972.
  • Sagen, Jørn V.; Baumann, Maren E.; Salvesen, Helga; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus. 2005. Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus. Diabetic Medicine. 22: 1012-1015.
  • Sagen, Jørn V.; Pearson, Ewan R.; Johansen, Anders; Spyer, Ghislaine; Søvik, Oddmund; Pedersen, Oluf; Njølstad, Pål Rasmus; Hattersley, Andrew T.; Hansen, Torben. 2005. Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1 alpha mutation carriers. Diabetic Medicine. 22: 406-409.
  • Akbari, M; Skjelbred, C; Folling, I; Sagen, Jørn V.; Krokan, HE. 2004. A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA (Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss. Scandinavian Journal of Clinical and Laboratory Investigation. 64: 86-92.
  • Sagen, Jørn V.; Ræder, Helge; Hathout, Eba; Gudmundsson, K; Bævre, H; Abuelo, D; Phornphutkul, C; Molnes, Janne; Bell, GI; Gloyn, AL; Hattersley, AT; Molven, Anders; Søvik, Oddmund; Njølstad, Pål Rasmus. 2004. Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2 - Patient characteristics and initial response to sulfonylurea therapy. Diabetes. 53: 2713-2718.
  • Bjørkhaug, L; Sagen, Jørn V.; Thorsby, P; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2003. Hepatocyte nuclear factor- 1 alpha gene mutations and diabetes in Norway. Journal of Clinical Endocrinology and Metabolism. 88: 920-931.
  • Gundersen, Lise Bj.; Sagen, Jørn V.; Thorsby, P; Søvik, Oddmund; Molven, Anders; Njølstad, Pål Rasmus. 2003. Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway. Journal of Clinical Endocrinology and Metabolism. 88: 920-931.
  • Njølstad, Pål Rasmus; Sagen, Jørn V. 2003. Klinisk molekylærmedisin (4): Koblingsanalyser. Pediatrisk Endokrinologi. 16: 34-38.
  • Njølstad, Pål Rasmus; Sagen, Jørn V.; Bjørkhaug, Lise; Odili, Stella; Shehadeh, Naim; Bakry, Doua; Sarici, U; Alpay, Faruk; Molnes, Janne; Molven, Anders; Søvik, Oddmund; Matschinsky, Franz M. 2003. Permanent neonatal diabetes caused by glucokinase deficiency; inborn error of the glucose-insulin signaling pathway. Diabetes. 52: 2854-2860.
  • Sagen, Jørn V.; Bostad, Leif; Njølstad, Pål Rasmus; Søvik, Oddmund. 2003. Enlarged nephrons and severe non-diabetic nephropathy in hepatocyte nuclear factor (HNF)-1 beta mutation carriers. Kidney International. 64: 793-800.
  • Sagen, Jørn V.; Bostad, Leif; Njølstad, Pål Rasmus; Søvik, Oddmund. 2003. Enlarged nephrons and severe non-diabetic nephropathy in hepatocyte nuclear factor (HNF)-1 beta mutation carriers. Kidney International. 64: 793-800.
  • Sagen, Jørn V.; Njølstad, Pål Rasmus; Søvik, Oddmund. 2002. Reduced prevalence of late-diabetic complications in MODY3 with early diagnosis. Diabetic Medicine. 19: 697-703.
  • Njølstad, Pål Rasmus; Søvik, Oddmund; Cockburn, B. N.; Bell, G. I.; Følling, I.; Sagen, Jørn V. 1998. Ikke-insulinkrevende diabetes mellitus hos barn og unge voksne. Tidsskrift for Den norske legeforening. 118: 1054-1057.
  • Søvik, Oddmund; Njølstad, Pål Rasmus; Følling, I.; Sagen, Jørn V.; Cockburn, B. N.; Bell, G. I. 1998. Hyperexacitability to sulphonylurea in MODY3. Diabetologia. 41: 607-608.
Reports and theses
  • Sagen, Jørn V. 2005. Clinical and molecular aspects of monogenic diabetes mellitus.
Book sections
  • Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter; Hoang, Tuyen; Gjerde, Jennifer; Sagen, Jørn V.; Lien, Ernst Asbjørn; Mellgren, Gunnar. 2011. Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. 2, pages 35-66. In:
    • Bates, Margaret K; Kerr, Regina M. 2011. Nuclear Receptors. Nova Science Publishers, Inc.. 174 pages. ISBN: 978-1-61209-980-4.
  • Sagen, Jørn V. 2011. Fysisk aktivitet. 5, pages 147-157. In:
    • Skafjeld, Anita; Graue, Marit. 2011. Diabetes : forebygging, oppfølging, behandling. Akribe Forlag. 374 pages. ISBN: 978-82-7950-074-2.
  • Sagen, Jørn V. 2011. Sykdomslære. 1, pages 19-73. In:
    • Skafjeld, Anita; Graue, Marit. 2011. Diabetes : forebygging, oppfølging, behandling. Akribe Forlag. 374 pages. ISBN: 978-82-7950-074-2.
  • Søvik, Oddmund; Sagen, Jørn V.; Njølstad, Pål Rasmus. 2008. MODY5 due to mutations in TCF2 (HNF-1ß): The clinical spectrum with special reference to urogenital malformations. Kapittel, pages 1096-1102. In:
    • Epstein, Charles J.; Erickson, Robert P.; Wynshaw-Boris, Anthony. 2008. Inborn Errors of Development. Oxford University Press. 1664 pages. ISBN: 9780195306910.

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