High-resolution physical mapping and transcript profiling of candidate genes for mastitis resistance in Norwegian Cattle

Ane Skjelfjord

PhD student: Heidi Nilsen

Prosjektleder: Sigbjørn Lien

Irradiated sperm typing will be developed for high-resolution determination of evolutionary breakage points between humans and cattle. A particular focus will be put on bovine chromosome 6 (BTA6), where several putative quantitative trait loci (QTL) have been localised for mastitis resistance and milk production in the Norwegian Cattle population. Furthermore, transcript profiling by DNA-microarray technology will be used to identify differentially expressed genes that maps to the chromosome interval of interest. The ultimate goal is molecular characterisation of the genes underlying the QTL for mastitis resistance. The results of this project can easily be put into practice by marker or gene-assisted selection. On the long term this will reduce the incidences of mastitis, cut the number of antibiotic treatments, and improve the animal welfare of Norwegian cows.

Oppdatert: 04.11.04
Utskriftsvennlig versjon : Arkiv : Tips en venn