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http://hdl.handle.net/1956/2625
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| Tittel: | Short-term efficacy of physical interventions in osteoarthritic knee pain. A systematic review and meta-analysis of randomised placebo-controlled trials |
| Forfattere: | Bjordal, Jan M.
Johnson, Mark I.
Lopes-Martins, Rodrigo A. B.
Bogen, Bård
Chow, Robert
Ljunggren, Anne Elisabeth |
| Dato: | 22-Jun-2007 |
| Forlag: | BioMed Central |
| Sitering: | BMC Musculoskeletal Disorders, 8:51 |
| Sammendrag: | Background: Treatment efficacy of physical agents in osteoarthritis of the knee (OAK) pain has
been largely unknown, and this systematic review was aimed at assessing their short-term efficacies
for pain relief.
Methods: Systematic review with meta-analysis of efficacy within 1–4 weeks and at follow up at
1–12 weeks after the end of treament.
Results: 36 randomised placebo-controlled trials (RCTs) were identified with 2434 patients where
1391 patients received active treatment. 33 trials satisfied three or more out of five methodological
criteria (Jadad scale). The patient sample had a mean age of 65.1 years and mean baseline pain of
62.9 mm on a 100 mm visual analogue scale (VAS). Within 4 weeks of the commencement of
treatment manual acupuncture, static magnets and ultrasound therapies did not offer statistically
significant short-term pain relief over placebo. Pulsed electromagnetic fields offered a small
reduction in pain of 6.9 mm [95% CI: 2.2 to 11.6] (n = 487). Transcutaneous electrical nerve
stimulation (TENS, including interferential currents), electro-acupuncture (EA) and low level laser
therapy (LLLT) offered clinically relevant pain relieving effects of 18.8 mm [95% CI: 9.6 to 28.1] (n
= 414), 21.9 mm [95% CI: 17.3 to 26.5] (n = 73) and 17.7 mm [95% CI: 8.1 to 27.3] (n = 343) on
VAS respectively versus placebo control. In a subgroup analysis of trials with assumed optimal
doses, short-term efficacy increased to 22.2 mm [95% CI: 18.1 to 26.3] for TENS, and 24.2 mm
[95% CI: 17.3 to 31.3] for LLLT on VAS. Follow-up data up to 12 weeks were sparse, but positive
effects seemed to persist for at least 4 weeks after the course of LLLT, EA and TENS treatment
was stopped.
Conclusion: TENS, EA and LLLT administered with optimal doses in an intensive 2–4 week
treatment regimen, seem to offer clinically relevant short-term pain relief for OAK. |
| URI: | http://dx.doi.org/10.1186/1471-2474-8-51
http://hdl.handle.net/1956/2625 |
| Vises i samlingene: | Section for Physiotherapy Science
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