As described below, the Stem Cell Group was recently established within the KGJ Center in order to address new possibilities emerging from the use of induced pluripotent stem cells (iPSC) in personalized medicine.

The group’s main recent research achievement has been the successful making of human iPSCs from fibroblasts from several members in families with MODY1, 2, 3, 5 and 8 (Teo et al., 2013, J Biological Chemistry). Moreover, we have been using proteomics to define the pancreatic secretome in MODY8 patients (Ræder et al., Diabetes, 2014).

Scientific accomplishments:

Thus, during the first two years of the funding period, we have been able to publish papers in top journals in general medicine (JAMA, Science Translational Medicine), genetics (2 in Nature Genetics; American J Human Genetics), cell biology (Cell), diabetes and endocrinology (Diabetes), and biochemistry (3 in J Biological Chemistry). Moreover, we have written a review in Nature Reviews Endocrinology. In all these papers, we are either the primary research group or we significantly contribute experimentally. Thus, our contributions always stretch well beyond the delivery of patient samples.

Head of group: Helge Ræder