Aurora
Martinez
Professor
Visit Address:
Jonas Lies vei 91
5009 Bergen
Postal Address:
Postboks 7804
5009 Bergen
Phone:
+47 55 58 64 27
E-mail:
Books
- 2013. Fra Allégaten via Årstadvollen til Ulrikens Fot 1963–2013. Bodoni forlag. 169 pages. ISBN: 978-82-90952-62-9.
- 2004. Thermodynamic parameters for the binding of tetrahydrobiopterin to human phenylalanine hydroxylase. 6 pages.
Journal articles
- 2014. Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia. Human Mutation. 35: 880-890. doi: 10.1002/humu.22565
- 2014. Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins. FEBS Letters. 588: 92-98. doi: 10.1016/j.febslet.2013.11.012
- 2014. Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ. Molecular & Cellular Proteomics. 13: 2017-2030. doi: 10.1074/mcp.M113.035709
- 2014. The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. Journal of Molecular Biology. 426: 150-168. doi: 10.1016/j.jmb.2013.09.012
- 2013. Conformational stability and activity analysis of two hydroxymethylbilane synthase mutants, K132N and V215E, with different phenotypic association with acute intermittent porphyria. Bioscience Reports. 33: 617-U203. doi: 10.1042/BSR20130045
- 2013. Phenylalanine hydroxylase: Function, structure, and regulation. IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology. 65: 341-349. doi: 10.1002/iub.1150
- 2013. Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type. Human Molecular Genetics. 22: 3680-3689. doi: 10.1093/hmg/ddt217
- 2013. Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila. FEBS Open Bio. 3: 370-378. doi: 10.1016/j.fob.2013.08.006
- 2013. Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. Journal of Medicinal Chemistry. 56: 7177-7189. doi: 10.1021/jm400499k
- 2013. Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. Biointerphases. 8:14. 12 pages. doi: 10.1186/1559-4106-8-14
- 2013. Avidity of onconeural antibodies is of clinical relevance. Cancer Immunology and Immunotherapy. 62: 1393-1396. doi: 10.1007/s00262-013-1442-6
- 2012. HAMLET forms annular oligomers when deposited with phoshpolipid monolayers. Journal of Molecular Biology. 418: 90-102. doi: 10.1016/j.jmb.2012.02.006
- 2012. The peripheral binding of 14-3-3gamma to membranes involves isoform-specific histidine residues. PLoS ONE. 7. doi: 10.1371/journal.pone.0049671
- 2012. Phenylalanine hydroxylase from legionella pneumophila is a thermostable enzyme with a major functional role in pyomelanin synthesis. PLoS ONE. 7. 13 pages. doi: 10.1371/journal.pone.0046209
- 2012. Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry. Molecular Genetics and Metabolism. 105: 559-565. doi: 10.1016/j.ymgme.2011.12.025
- 2012. The mechanism of BH4-responsive hyperphenylalaninemia-as it Occurs in the ENU1/2 genetic mouse model. Human Mutation. 33: 1464-1473. doi: 10.1002/humu.22128
- 2012. Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: epidermal H2O2/ONOO--mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels. The FASEB Journal. 26: 2457-2470. doi: 10.1096/fj.11-197137
- 2012. A dynamic model of long-range conformational adaptations triggered by nucleotide binding in GroEL-GroES. Proteins: Structure, Function, and Genetics. 80: 2333-2346. doi: 10.1002/prot.24113
- 2012. Phenylalanine hydroxylase misfolding and pharmacological chaperones. Current Topics in Medicinal Chemistry. 12: 2534-2545. doi: 10.2174/1568026611212220008
- 2011. Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine. Biochemical Journal. 434: 133-141. doi: 10.1042/BJ20101561
- 2011. The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. PLoS ONE. 6. 10 pages. doi: 10.1371/journal.pone.0017602
- 2011. The binding of 14-3-3 gamma to membranes studied by intrinsic fluorescence spectroscopy. FEBS Letters. 585: 1163-1168. doi: 10.1016/j.febslet.2011.03.027
- 2011. The 14-3-3 proteins in regulation of cellular metabolism. Seminars in Cell and Developmental Biology. 22: 713-719. doi: 10.1016/j.semcdb.2011.08.008
- 2011. Substrate Hydroxylation by the Oxido-Iron Intermediate in Aromatic Amino Acid Hydroxylases: A DFT Mechanistic Study. European Journal of Inorganic Chemistry. 17. 2720-2732. doi: 10.1002/ejic.201001218
- 2011. Formation of the Iron-Oxo Hydroxylating Species in the Catalytic Cycle of Aromatic Amino Acid Hydroxylases. Chemistry - A European Journal. 17: 3746-3758. doi: 10.1002/chem.201002910
- 2011. Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations. PloS Computational Biology. 7. doi: 10.1371/journal.pcbi.1002004
- 2011. Principal component and normal mode analysis of proteins; a quantitative comparison using the GroEL subunit. Proteins: Structure, Function, and Genetics. 79: 232-243. doi: 10.1002/prot.22875
- 2011. Dynamics, flexibility and ligand induced conformational changes in biological macromolecules: a computational approach. Future Medicinal Chemistry. 3: 2079-2100. doi: 10.4155/FMC.11.159
- 2011. Treatment of Solid Cancers Using a New Cationic Cytolytic Peptide. European Journal of Cancer. 47: S148-S148.
- 2010. Characterization of the molecular basis of acute intermittent porphyria. The FEBS Journal. 277: 76-76.
- 2010. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. Journal of Biological Chemistry. 285: 14062-14070. doi: 10.1074/jbc.M110.106666
- 2010. Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2. Journal of Neurochemistry. 114: 853-863. doi: 10.1111/j.1471-4159.2010.06821.x
- 2010. Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications. Amino Acids. 39: 1463-1475. doi: 10.1007/s00726-010-0611-6
- 2010. Adsorption and bioactivity of tyrosine hydroxylase on gold surfaces and nanoparticles. Protein peptide letters. 17: 1376-1382.
- 2010. CHARACTERIZATION OF THE MOLECULAR BASIS OF ACUTE INTERMITTENT PORPHYRIA. Journal of Inherited Metabolic Disease. 33: S177-S177.
- 2010. POTENTIAL PHARMACOLOGYCAL CHAPERONE THERAPY FOR ISOLATED METHYLMALONIC ACIDURIA cbIB TYPE. Journal of Inherited Metabolic Disease. 33: S40-S40.
- 2010. PHARMACOLOGICAL CHAPERONES FOR THE AROMATIC AMINO ACID HYDROXYLASES. Journal of Inherited Metabolic Disease. 33: S163-S163.
- 2010. HAMLET interacts with lipid membranes and perturbs their structure and integrity. PLoS ONE. 5. 10 pages. doi: 10.1371/journal.pone.0009384
- 2010. The aromatic amino acid hydroxylase mechanism: A perspective from computational chemistry. Advances in Inorganic Chemistry. 62: 437-500. doi: 10.1016/S0898-8838(10)62011-9
- 2010. Water dissociation and dioxygen binding in phenylalanine hydroxylase. European Journal of Inorganic Chemistry. 3. 351-356. doi: 10.1002/ejic.200900489
- 2010. PARTIALLY FOLDED STATES OF A MISTARGETING VARIANT OF THE HUMAN ALANINE: GLYOXYLATE AMINOTRANSFERASE STABLY INTERACT WITH HSC70 CHAPERONES. Journal of Inherited Metabolic Disease. 33: S174-S174.
- 2010. Rescue of misfolded proteins and stabilization by small molecules. Methods in Molecular Biology. 648: 313-324. doi: 10.1007/978-1-60761-756-3_22
- 2010. Phenylalanine hydroxylase expression in primary rat hepatocytes is modulated by oxygen concentration. Molecular Genetics and Metabolism. 101: 279-281. doi: 10.1016/j.ymgme.2010.06.013
- 2009. Plasmablastic Lymphomas (PBL) Are Genetically Characterized by Frequent MYC Translocations. Laboratory Investigation. 89: 255A-255A.
- 2009. Biochemical characterization of mutant phenylalanine hydroxylase enzymes and correlation with clinical presentation in hyperphenylalaninaemic patients. Journal of Inherited Metabolic Disease. 32: 10-21. doi: 10.1007/s10545-008-0942-6
- 2009. Using the nematode enzyme as template for elucidating regulatory mechanism of phenylalanine hydroxylase. The FEBS Journal. 276: 365-365.
- 2009. Linking new paradigms in protein chemistry to reversible membrane-protein interactions. Current protein and peptide science. 10: 339-359.
- 2009. Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase and negatively charged membranes. Journal of Biological Chemistry. 284: 32758-32769. doi: 10.1074/jbc.M109.027706
- 2009. Rescuing proteins of low kinetic stability by chaperones and natural ligands; phenylketonuria, a case study. Progress in Nucleic Acid Research and Molecular Biology. 83: 89-134. doi: 10.1016/S0079-6603(08)00603-X
- 2009. Iron binding effects on the kinetic stability and unfolding energetics of a thermophilic phenylalanine hydroxylase from Chloroflexus aurantiacus. Journal of Biological Inorganic Chemistry. 14: 521-531. doi: 10.1007/s00775-009-0467-y
- 2009. Evolution of regulation, structure and function in phenylalanine hydroxylase. Pteridines. 20: 42-50.
- 2009. Searching distant homologs of the regulatory ACT domain in phenylalanine hydroxylase. Amino Acids. 36: 235-249. doi: 10.1007/s00726-008-0057-2
- 2009. Overview of computational methods employed in early-stage drug discovery. Future Medicinal Chemistry. 1: 49-63. doi: 10.4155/FMC.09.7
- 2008. Natural chaperone ligands as new therapies for the treatment of genetic diseases related to catecholamine synthesis. The FEBS Journal. 275: 445-445.
- 2008. Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans. The FASEB Journal. 22. doi: 10.1096/fj.08-108522
- 2008. Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics. Proceedings of the National Academy of Science of the United States of America. 105: 8625-8630. doi: 10.1073/pnas.0709881105
- 2008. Stromal Gene Signatures in Large-B-Cell Lymphomas. New England Journal of Medicine. 359: 2313-2323.
- 2008. Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria. Journal of Clinical Investigation. 118: 2858-2867. doi: 10.1172/JCI34355
- 2008. The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene. 427: 86-92. doi: 10.1016/j.gene.2008.09.005
- 2008. Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase. Journal of Neurochemistry. 106: 672-681. doi: 10.1111/j.1471-4159.2008.05423.x
- 2008. Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase. Journal of Inherited Metabolic Disease. 31: 138-138.
- 2007. Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability. Journal of Molecular Biology. 372: 130-149. doi: 10.1016/j.jmb.2007.06.040
- 2007. Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Journal of Biological Chemistry. 282. doi: 10.1074/jbc.M610174200
- 2007. Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases. American Journal of Human Genetics. 81: 1006-1024. doi: 10.1086/521879
- 2007. Tetrahydrobiopterin for patients with phenylketonuria. The Lancet. 370: 462-463. doi: 10.1016/S0140-6736(07)61209-4
- 2007. Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Current Medicinal Chemistry. 14: 455-467. doi: 10.2174/092986707779941023
- 2006. Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. Journal of Biological Chemistry. 281: 21500-21511. doi: doi:10.1074/jbc.M603116200
- 2006. Characterization of phenylalanine hydroxylase from Caenorhabditis elegans. Insights into the evolution of human activity and regulation. The FASEB Journal. 20: A52-A52.
- 2006. Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. The FASEB Journal. 20: 2130-2132. doi: 10.1096/fj.06-5835fje
- 2006. Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines. Experimental Cell Research. 312: 782-795. doi: 10.1016/j.yexcr.2005.11.035
- 2005. Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity. Journal of Molecular Biology. 349: 1072-1086. doi: 10.1016/j.jmb.2005.04.020
- 2005. Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism. Amino Acids. 28: 1-12. doi: 10.1007/s00726-004-0152-y
- 2005. Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism. Amino Acids. 28: 1-12. doi: 10.1007/s00726-004-0152-y
- 2005. The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase. Journal of Inorganic Biochemistry. 99: 1320-1328.
- 2005. Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients. Molecular Genetics and Metabolism. 86: S11-S16. doi: 10.1016/j.ymgme.2005.06.009
- 2005. The activity of wild-type and mutant phenylalanine hydroxylase and its regulation by phenylalanine and tetrahydrobiopterin at physiological and pathological concentrations: An isothermal titration calorimetry study. Molecular Genetics and Metabolism. 86: S43-S53. doi: 10.1016/j.ymgme.2005.04.008
- 2005. α-Lactalbumin binding and membrane integrity – effect of charge and degree of unsaturation of glycerophospholipids. Biochimica et Biophysica Acta - Biomembranes. 1717: 11-20. doi: 10.1016/j.bbamem.2005.09.004
- 2005. alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1717: 11-20.
- 2005. Stimulation of hepatic phenylalanine hydroxylase activity but not Pah-mRNA expression upon oral loading of tetrahydrobiopterin in normal mice. Molecular Genetics and Metabolism. 86: S153-S155. doi: 10.1016/j.ymgme.2005.09.015
- 2005. The reaction mechanism of phenylalanine hydroxylase. A question of coordination. Pteridines. 16: 27-34.
- 2004. Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proceedings of the National Academy of Science of the United States of America. 101: 16903-16908.
- 2004. Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastoris. Protein Expression and Purification. 33: 185-194.
- 2004. Structural and stability effects of phosphorylation � Localized structural changes in phenylalanine hydroxylase. Protein Science. 13: 1219-1226.
- 2004. Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations. Human Mutation. 24: 388-399.
- 2004. Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase. Journal of the American Chemical Society. 126: 13670-13678.
- 2004. Early development of subcortical regions involved in non-cued attention switching. Developmental Science. 7: 534-542.
- 2004. Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity. Journal of Medicinal Chemistry. 47: 5962-5971.
- 2004. Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: Implications for tetrahydrobiopterin-responsive hyperphenylalaninemia. FEBS Letters. 577: 507-511.
- 2003. The interaction of peripheral proteins and membranes studied with alpha-lactalbumin and phospholipid bilayers of various compositions. Journal of Biological Chemistry. 278: 21790-21797.
- 2003. cAMP analog mapping of Epac1 and camp kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. Journal of Biological Chemistry. 278: 35394-35402.
- 2003. Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure. Journal of Biological Chemistry. 278: 17114-17120.
- 2003. Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics. 20: 733-740.
- 2003. Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237. Biochemistry. 42: 3419-3428.
- 2002. Detaljer i utilgjengelig systemer membran-protein vekselvirkninger. NBS-nytt. 26: 16-19.
- 2002. The Membrane-bound Conformation of a-Lactalbumin Studied by NMR-monitored 1H Exchange. Journal of Molecular Biology. 321: 99-110.
- 2002. Phosphorylation and mutations of Ser16 in human phenylalanine hydroxylase. Kinetic and structural effects. Journal of Biological Chemistry. 277: 40937-40943.
- 2002. The binding of tyrosine hydroxylase to negatively charged lipid bilayers involves the N-terminal region of the enzyme. FEBS Letters. 519: 221-226.
- 2002. L-Phenylalanine binding and domain organization in human phenylalanine hydroxylase. A differential scanning calorimetry study. Biochemistry. 41: 7573-7585.
- 2001. The effect of substrate, dihydrobiopterin and dopamine on the EPR spectroscopic properties and the midpoint potential of the catalytic iron in recombinant human phenylalanine hydroxylase. Journal of Biological Chemistry. 276: 22850-22856.
- 2001. A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis. Current Medicinal Chemistry. 8: 1077-91 + cover.
- 2001. The structure of tryptophan hydroxylase structure of tryptophan hydroxylase enzyme substrate complexes as determined by NMR spectroscopy and molecular modeling. Pteridines. 12: 61-62.
- 2001. Conformation of the substrate and pterin cofactor bound to human tryptophan hydroxylase. Important role of Phe313 in substrate specificity. Biochemistry. 40: 15591-15601.
- 2000. A kinetic and conformational study on the interaction of tetrahydropteridines with tyrosine hydroxylase. Biochemistry. 39: 13676-13686.
- 2000. The conformation of 5,6,7,8-tetrahydrobiopterin and 7,8-dihydrobiopterin in solution: A 1H NMR study. Pteridines. 11: 32-33.
- 2000. The conformation of 5,6,7,8-tetrahydrobiopterin and 7,8-dihydrobiopterin in solution: A 1H NMR study. Pteridines. 11: 32-33.
- 2000. The effect of tetrahydrobiopterin on the thermostability of human phenylalanine hydroxylase as studied by circular dichroism spectroscopy. Pteridines. 11: 29-31.
- 1999. Tyrosine hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity as shown by kinetic analysis and surface plasmon resonance detection. European Journal of Biochemistry. 262: 1-11.
- 1999. The accessibility of the iron at the active site of recombinant human phenylalanine hydroxylase to water as studied by <SUP>1</SUP>H-N paramagnetic relaxation. Effect of L-Phe and comparison with the rat enzyme. Journal of Biological Chemistry. 274: 6280-6284.
- 1999. The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase. Implications for the catalytic mechanism. Journal of Molecular Biology. 294: 807-823.
- 1999. The structural Basis of the Recognition of Phenylalanine and Pterine Cofactors by Phenylalanine Hydroxylase. Implications for the Catalytic Mechanism. Journal of Molecular Biology. 294: 807-823.
- 1997. Crystal structure of the catalytic domain of human phenylalanine hydroxylase at 2.0 Å resolution reveals the structural basis for phenylketonuria. Nature Structural Biology. 4: 995-1000.
- 1997. Crystallization and preliminary diffraction analysis of a truncated homodimer of human phenylalanine hydroxylase. FEBS Letters. 406: 171-174.
- 1997. Effect of mutations at cys 237 on the activation state and activity of human phenylalanine hydroxylase. FEBS Letters. 409: 7-11.
- 1997. Effect of mutations at Cys 237 on the activation state and activity of human phenylalanine hydroxylase. FEBS Letters. 409: 7-11.
- 1997. The effect of phosphorylation at Ser-40 on the structure and thermal stability of tyrosine hydroxylase. Advances in Pharmacology. 42: 15-18.
- 1997. Comparative analysis of phenylalanine hydroxylase A104D mutant, associated with variant phenylketonuria, and wild-type enzyme. Biochemical Society Transactions. 25: S362.
- 1996. Phosphorylation of recombinant human phenylalanine hydroxylase. Effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease. Biochemical Journal. 319: 409-414.
- 1996. Phosphorylation of recombinant human phenylalanine hydroxylase. Effect on catalytic activity, substrate activation and protection against non-spesific cleavage of the fusion protein by restriction protease. The Biochemical journal. 319: 409-414.
- 1996. Phosphorylation of recombinant human phenylalanine hydroxylase. Effect on catalytic activity, substrate activation and protection against non-spesific cleavage of the fusion protein by restriction protease. The Biochemical journal. 319: 409-414.
- 1996. PKU mutation (D143G) associated with an apparent high residual enzyme activity: Expression of a kinetic variant form of phenylalanine hydroxilase in three different systems. Human Mutation. 8: 236-246.
- 1996. PKU mutation (D143G) associated with an apparent high residual enzyme activity: Expression of a kinetic variant form of phenylalanine hydroxilase in three different systems. Human Mutation. 8: 236-246.
- 1996. Structure-function relationship in human phenylalanine hydroxylase . Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme. European Journal of Biochemistry. 242: 813-821.
- 1996. Conformational properties and stability of tyrosine hydroxylase studied by infrared spectroscopy. Effect of iron/catecholamine binding and phosphorylation. Journal of Biological Chemistry. 271: 19737-19742.
- 1996. Characterization of the iron environment in human tyrosine hydroxylase, using M#"ossbauer-, EPR-, and EXAFS-spectroscopy. Conf Proc Ital Phys Soc. 50: 819-822.
- 1995. The PKU mutation S349P causes complete loss of catalytic activity in the recombinant phenylalanine hydroxylase enzyme. Hum Genet. 95: 171-173.
- 1995. Evidence for a functionally important histidine residue in human tyrosine hydroxylase. Amino Acids. 9: 285-292.
- 1995. Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme. Biochemical Journal. 306: 589-597.
- 1995. Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Biochemical Journal. 306: 589-597.
- 1994. The PKU mutation S349P causes complete loss of catalytic activity in the recombinant phenylalanine hydroxylase enzyme. Hum Genet. 94: 171-173.
- 1993. Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR. Biochemistry. 32: 6381-6390.
- 1992. The incorporation of divalent metal ions into recombinant human tyrosine hydroxylase apoenzymes studied by intrinsic fluorescence and 1H-NMR spectroscopy. European Journal of Biochemistry. 210: 23-31.
- 1992. The cooperative binding of phenylalanine to phenylalanine 4-monooxygenase studied by %1H-NMR relaxation enhancement: changes in water accessibility to the iron at the active site upon substrate binding. European Journal of Biochemistry. 211: 259-266.
- 1992. Interaction of phenylalanine hydroxylase by reducing agents in vitro. Biochemical and Biophysical Research Communications - BBRC. 182: 92-98.
- 1991. Recombinant human tyrosine hydroxylase isozymes. Reconstruction with iron and inhibitory effect of other metal ions. European Journal of Biochemistry. 199: 371-378.
- 1991. EPR and %1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates inhibitors. European Journal of Biochemistry. 198: 675-682.
Book sections
- 2010. The aromatic amino acid hydroxylase mechanism: a perspective from computational chemistry. 62, pages 437-500. In:
- 2010. Theoretical and Computational Inorganic Chemistry. Elsevier. 500 pages. ISBN: 978-0-12-380874-5.
- 2002. Role of Phe313/Trp326 in determining substrate specificity in tryptophan and phenylalanine hydroxylases. 97-102. In:
- 2002. Chemistry and Biology of Pteridines and Folates: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17-22, 2001. 677 pages. ISBN: 0-7923-7675-7.
- 2002. The conformation of tetrahydrobiopterin free and bound to aromatic amino acid hydroxylases. 67-72. In:
- 2002. Chemistry and Biology of Pteridines and Folates: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17-22, 2001. 677 pages. ISBN: 0-7923-7675-7.
- 2002. The N-terminus of human tyrosine hydroxylase is responsible for its association with phospholipid bilayers. 115-120. In:
- 2002. Chemistry and Biology of Pteridines and Folates: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17-22, 2001. 677 pages. ISBN: 0-7923-7675-7.
- 1999. DIO-1 is a novel gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. 7992-7997. In:
- 1999. Proceedings of the National Academy of Sciences of the USA.
- 1997. Molecular characterization of disease related mutant forms of human phenylalanine hydroxylase and tyrosine hydroxylase. 503-508. In:
- 1997. Chemistry and biology of pteridines and folates: Proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15-20, 1997. Blackwell Publishing. 894 pages. ISBN: 3-8263-3185-0.
- 1997. Molecular (-en 1) characterization of disease related mutant forms of human phenylalanine hydroxylase and tyrosine hydroxylase. 58-58. In:
- 1997. Pteridines 8.
- 1993. Characterization of the iron environment in recombinant human tyrosine hydroxylase. 71-76. In:
- 1993. Chemistry and Biology of Pteridines and Folates. Proceedings of the Tenth International Symposium on Chemistry and Biology of Pteridines, held March 21 - 26, 1993, in Orange Beach, Alabama. 825 pages. ISBN: 0306445816.
- 1993. Expression of recombinant wild type and mutant forms of human phenylalanine hydroxylase in E. coli. In:
- 1993. Chemistry and Biology of Pteridines and Folates. Proceedings of the Tenth International Symposium on Chemistry and Biology of Pteridines, held March 21 - 26, 1993, in Orange Beach, Alabama. 825 pages. ISBN: 0306445816.
- 1993. Expression of wild type and mutant forms of human phenylalanine hydroxylase in E.Coli. 50-62. In:
- 1993. Adv Exp Med Biol.
- 1993. Interaction of substrate and pterin cofactor with the metal of human tyrosine hydroxylase as determined by %1H-NMR. 77-80. In:
- 1993. Chemistry and Biology of Pteridines and Folates. Proceedings of the Tenth International Symposium on Chemistry and Biology of Pteridines, held March 21 - 26, 1993, in Orange Beach, Alabama. 825 pages. ISBN: 0306445816.
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