Silke Appel's picture
Silke
Appel
Professor
Visit Address: 
Haukeland universitetssykehus, Laboratoriebygget
5021 Bergen
Postal Address: 
Postboks 7804
5021 Bergen
Phone: 
+47 55 97 46 33
E-mail: 
Silke.Appel@k2.uib.no
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Journal articles
  • Sandvik, Lene Frøyen; Skarstein, Kathrine; Sviland, Lisbeth; Svarstad, Einar; Nilsen, Arvid E; Leivestad, Torbjørn; Jonsson, Roland; Appel, Silke. 2014. CD11c+ dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. Acta Dermato-Venereologica. 94: 173-178. Published 2013-08-27. doi: 10.2340/00015555-1679
  • Sprater, Florian; Azeem, Waqas; Appel, Silke. 2014. Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells. Scandinavian Journal of Immunology. 79: 20-26. doi: 10.1111/sji.12126
  • Haldorsen, Karstein; Appel, Silke; Le Hellard, Stephanie; Bruland, Ove; Brun, Johan G; Omdal, Roald; Kristjansdottir, Gudlaug; Theander, Elke; Duarte Fernandes, Carla; Kvarnström, Marika; Eriksson, Per; Rönnblom, Lars; Herlenius, Maria Wahrén; Nordmark, Gunnel; Jonsson, Roland; Bolstad, Anne Isine. 2013. No association of primary Sjögren's syndrome with Fcγ receptor gene variants. Genes and Immunity. 14: 234-237. doi: 10.1038/gene.2013.12
  • Haldorsen, Karstein; Bruland, Ove; Appel, Silke; Bolstad, Anne Isine. 2013. Reply to 'Comment on No association of primary Sjogren's syndrome with Fc gamma receptor gene variants'. Genes and Immunity. 14: 532-532. doi: 10.1038/gene.2013.51
  • Sandvik, Lene Frøyen; Volchenkov, Roman; Jonsson, Roland; Appel, Silke. 2013. Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas. Scandinavian Journal of Immunology. 78: 291-297. doi: 10.1111/sji.12084
  • Sauter, Alexander; Richter, Gunther; Micoulet, Alexandre; Martinez, Aurora; Spatz, Joachim P.; Appel, Silke. 2013. Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. Biointerphases. 8:14. 12 pages. doi: 10.1186/1559-4106-8-14
  • Volchenkov, Roman; Brun, Johan G; Jonsson, Roland; Appel, Silke. 2013. In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome. Arthritis Research & Therapy. 15. 12 pages. doi: 10.1186/ar4294
  • Volchenkov, Roman; Karlsen, Marie; Jonsson, Roland; Appel, Silke. 2013. Type 1 Regulatory T cells and Regulatory B Cells Induced by Dexamethasone and 1,25-Dihydroxyvitamin D3 Treated Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology. 77: 299-300.
  • Volchenkov, Roman; Karlsen, Marie; Jonsson, Roland; Appel, Silke. 2013. Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. Scandinavian Journal of Immunology. 77: 246-254. doi: 10.1111/sji.12039
  • Yi, Dag Heiro; Appel, Silke. 2013. Current status and future perspectives of dendritic cell-based cancer immunotherapy. Scandinavian Journal of Immunology. 78: 167-171. doi: 10.1111/sji.12060
  • Haldorsen, Karstein; Appel, Silke; Le Hellard, Stephanie; Bruland, Ove; Brun, Johan G; Omdal, Roald; Kristjansdottir, Gudlaug; Theander, Elke; Fernandes, Carla P.D.; Nordmark, Gunnel; Kvarnström, Marika; Eriksson, Per; Rönnblom, Lars; Herlenius, Maria Wahrén; Jonsson, Roland; Bolstad, Anne Isine. 2012. No association of primary Sjögren's Syndrome with Fc gamma? Receptor gene variants. Scandinavian Journal of Immunology. 76: 198-198.
  • Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Appel, Silke. 2012. The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner. PLoS ONE. 7. 7 pages. doi: 10.1371/journal.pone.0031217
  • Karlsen, Marie; Hansen, Torbjørn; Jonsson, Roland; Appel, Silke. 2012. Expression of Toll-like receptors 7 and 9 in B cell populations of patients with Sjogren's syndrome. Immunology. 137: 331-331. doi: 10.1111/imm.12002
  • Landsverk, Ole J. B.; Ottesen, Anett Hellebø; Berg-Larsen, Axel; Appel, Silke; Bakke, Oddmund. 2012. Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. Journal of Leukocyte Biology. 91: 729-737. doi: 10.1189/jlb.0311150
  • Sandvik, Lene Frøyen; Vogelsang, Petra; Leivestad, Torbjørn; Jonsson, Roland; Appel, Silke. 2012. Quantification of Plasmacytoid Dendritic Cells and Type 1 Myeloid Dendritic Cells in Peripheral Blood of Renal Transplant Recipients With and Without Squamous Cell Carcinoma. Acta Dermato-Venereologica. 92: 623-624. doi: 10.2340/00015555-1334
  • Sprater, Florian; Hovden, Arnt-Ove; Appel, Silke. 2012. Expression of ESE-3 isoforms in immunogenic and tolerogenic human monocyte-derived dendritic cells. PLoS ONE. 7. 9 pages. doi: 10.1371/journal.pone.0049577
  • Volchenkov, Roman; Jonsson, Roland; Appel, Silke. 2012. Anti-Ro and anti-La autoantibody profiling in Norwegian patients with primary Sjogren's syndrome using luciferase immunoprecipitation systems (LIPS). Scandinavian Journal of Rheumatology. 41: 314-315. doi: 10.3109/03009742.2012.670863
  • Volchenkov, Roman; Karlsen, Marie; Jonsson, Roland; Appel, Silke. 2012. Comparison of different protocols for the generation of monocytes-derived tolerogenic dendritic cells for immunotherapy. Immunology. 137: 679-679.
  • Volchenkov, Roman; Sprater, Florian; Vogelsang, Petra; Appel, Silke. 2012. The 2011 Nobel Prize in physiology or medicine. Scandinavian Journal of Immunology. 75: 1-4. doi: 10.1111/j.1365-3083.2011.02663.x
  • Appel, Silke; Le Hellard, Stephanie; Bruland, Ove; Brun, Johan G; Omdal, Roald; Kristjansdottir, Gudlaug; Theander, Elke; Nordmark, Gunnel; Kvarnström, Marika; Eriksson, Per; Rönnblom, Lars; Wahren-Herlenius, Marie; Jonsson, Roland. 2011. Potential association of muscarinic receptor 3 gene variants with primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 70: 1327-1329. doi: 10.1136/ard.2010.138966
  • Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Aarstad, Hans Jørgen; Appel, Silke. 2011. Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunology. 12. 10 pages. doi: 10.1186/1471-2172-12-2
  • Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Appel, Silke. 2011. Maturation of Dendritic Cells with the Bacterial Compound OK432 Induces High Secretion of IL-12p70 in a TLR3 Dependent Manner. Scandinavian Journal of Immunology. 73: 387-388.
  • Jonsson, Roland; Vogelsang, Petra; Volchenkov, Roman; Espinosa, Alexander; Wahren-Herlenius, Marie; Appel, Silke. 2011. The complexity of Sjögren's syndrome: Novel aspects on pathogenesis. Immunology Letters. 141: 1-9. doi: 10.1016/j.imlet.2011.06.007
  • Karlsen, Marie; Hovden, Arnt-Ove; Vogelsang, Petra; Tysnes, Berit Bølge; Appel, Silke. 2011. Bromelain Treatment Leads to Maturation of Monocyte-derived Dendritic Cells but Cannot Replace PGE(2) in a Cocktail of IL-1 beta, IL-6, TNF-alpha and PGE(2). Scandinavian Journal of Immunology. 74: 135-143. doi: 10.1111/j.1365-3083.2011.02562.x
  • Lied, Gülen Arsland; Vogelsang, Petra; Berstad, Arnold; Appel, Silke. 2011. Dendritic cell populations in patients with self-reported food hypersensitivity. International Journal of General Medicine. 4: 389-396. doi: 10.2147/IJGM.S17655
  • Nordmark, Gunnel; Kristjansdottir, Gudlaug; Theander, Elke; Appel, Silke; Eriksson, Per; Vasaitis, Lillian; Kvarnström, Marika; Delaleu, Nicolas; Lundmark, Per; Lundmark, Anders; Sjöwall, Christopher; Brun, Johan G; Jonsson, Malin V; Harboe, Erna; Gøransson, Lasse G; Johnsen, Svein Joar Auglæn; Söderkvist, Peter; Eloranta, Maija-Leena; Alm, Gunnar V.; Baecklund, Eva; Wahren-Herlenius, Marie; Omdal, Roald; Rönnblom, Lars; Jonsson, Roland; Syvänen, Ann-Christine. 2011. Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome. Genes and Immunity. 12: 100-109. doi: 10.1038/gene.2010.44
  • Sandvik, Lene Frøyen; Leivestad, Torbjørn; Sandnes, Dagny Ann; Vogelsang, Petra; Jonsson, Roland; Appel, Silke. 2011. Can Levels of Blood Plasmacytoid Dendritic Cells be used as a Prognostic Factor for Development of Squamous Cell Carcinomas in Organ Transplant Recipients? Scandinavian Journal of Immunology. 73: 394-394.
  • Sprater, Florian; Hovden, Arnt-Ove; Niere, Marc; Appel, Silke. 2011. The Epithelial Specific Transcription Factor ESE-3 is Expressed in Immature Dendritic Cells and Occurs Primarily as the ESE-3b Isoform. Scandinavian Journal of Immunology. 73: 366-366.
  • Volchenkov, Roman; Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Appel, Silke. 2011. Generation of Tolerogenic Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology. 73: 378-379.
  • Appel, Silke; Vogelsang, Petra; Brun, Johan G; Jonsson, Roland. 2010. Patients with Primary Sjogren's Syndrome have Significantly Reduced Amounts of Plasmacytoid and Type 2 Myeloid Dendritic Cells in Peripheral Blood. Scandinavian Journal of Immunology. 71: 479-479.
  • Haldorsen, Karstein; Appel, Silke; Bruland, Ove; Le Hellard, Stephanie; Brun, Johan G; Omdal, Roald; Kristjansdottir, Gudlaug; Theander, Elke; Nordmark, Gunnel; Kvamstrom, M; Eriksson, P; Rönnblom, Lars; Wahren-Herlenius, Marie; Jonsson, Roland; Bolstad, Anne Isine. 2010. Fc gamma receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc gamma receptor IIIB copy number variation: No association with primary Sjögren's syndrome. Scandinavian Journal of Rheumatology. 39: 36-36.
  • Hovden, Arnt-Ove; Appel, Silke. 2010. The First Dendritic Cell-Based Therapeutic Cancer Vaccine is Approved by the FDA. Scandinavian Journal of Immunology. 72: 554-554. doi: 10.1111/j.1365-3083.2010.02464.x
  • Hovden, Arnt-Ove; Karlsen, Marie; Sandnes, Dagny Ann; Aarstad, Hans Jørgen; Jonsson, Roland; Appel, Silke. 2010. Maturation of Monocyte Derived Dendritic Cells With OK432 Leads to Altered Expression of Surface Markers. Scandinavian Journal of Immunology. 71: 504-504.
  • Karlsen, Marie; Hovden, Arnt-Ove; Vogelsang, Petra; Appel, Silke; Sandnes, Dagny Ann; Tysnes, Berit Bølge. 2010. Bromelain Treatment Leads to Maturation of Monocyte Derived Dendritic Cells. Scandinavian Journal of Immunology. 71: 506-507.
  • Lied, Gülen Arsland; Vogelsang, Petra; Berstad, Arnold; Appel, Silke. 2010. Dendritic cell populations in patients with self-reported food hypersensitivity. Gut. 59: A394.
  • Nordmark, Gunnel; Kristjansdotti, Gudlaug; Theander, Elke; Appel, Silke; Eriksson, Per; Vasaitis, Lillian; Wahren-Herlenius, Marie; Omdal, Roald; Rönnblom, Lars; Jonsson, Roland; Syvanen, Ann-Christine. 2010. Gene Variants in Fam167A-Blk and Tnfsf4 are associated with Primary Sjogren's Syndrome. Scandinavian Journal of Rheumatology. 39: 32-32.
  • Vogelsang, Petra; Brun, Johan G; Øijordsbakken, Gunnvor; Skarstein, Kathrine; Jonsson, Roland; Appel, Silke. 2010. Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. Annals of the Rheumatic Diseases. 69: 1235-1238. doi: 10.1136/ard.2009.118158
  • Vogelsang, Petra; Hovden, Arnt-Ove; Jonsson, Roland; Appel, Silke. 2009. Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains. Scandinavian Journal of Immunology. 70: 541-546. doi: 10.1111/j.1365-3083.2009.02327.x
  • Bringmann, Anita; Hilgendorf, Ingo; Appel, Silke; Held, Stefanie; von Schwarzenberg, Karin; Grünebach, Frank; Brossart, Peter. 2008. Characterization of Gene p306 Expressed in Monocyte Derived Dendritic Cells. Blood. 112: 891-891.
  • Delaleu, Nicolas; Jonsson, Malin V; Appel, Silke; Jonsson, Roland. 2008. New Concepts in the Pathogenesis of Sjogren's Syndrome. Rheumatic Disease Clinics of North America. 34: 833-+. doi: 10.1016/j.rdc.2008.08.004
  • Hovden, Arnt-Ove; Sandnes, Dagny Ann; Jonsson, Roland; Aarstad, Hans Jørgen; Appel, Silke. 2008. Maturation of monocyte derived dendritic cells with OK432 leads to altered expression of surface markers. Scandinavian Journal of Immunology. 68: 217-217.
  • Vogelsang, Petra; Deswaerte, Virginie; Jonsson, Malin V; Jonsson, Roland; Appel, Silke. 2008. Age-related distribution of cDC and pDC in salivary glands of NOD mice. Scandinavian Journal of Immunology. 68: 206-207.
  • Appel, Silke; Brossart, P. 2007. Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. Endocrine, Metabolic & Immune Disorders - Drug Targets. 7: 93-97.
  • Appel, Silke; Bringmann, Anita; Grünebach, Frank; Week, Markus M.; Bauer, Jürgen; Brossart, Peter. 2006. Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. Blood. 107: 3265-3270. doi: 10.1182/blood-2005-06-2480
  • Vogelsang, Petra; Jonsson, Malin V; Dalvin, Sussie Trine; Appel, Silke. 2006. Role of dendritic cells in Sjögren´s syndrome. Scandinavian Journal of Immunology. 64: 219-226. doi: 10.1111/j.1365-3083.2006.01811.x

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