Projects Overview
DNA-methylation controls cell type-specific expression of steroidogenic factor-1
This new finding was recently published in the internationally respected journal ‘Endocrinology’. The Steroidogenic factor-1 (SF-1) is a transcription factor that is critical in the development and function of most steroidogenic tissues, which are involved in the production of sex hormones (read more). This work provides novel knowledge on the mechanisms behind tissue-specific expression of SF-1.
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A proteomic approach to understand Nuclear receptor function
Phosphoinositides (PIs) are crucial lipid second messengers, which contribute to the regulation of cell proliferation and survival, cytoskeletal dynamics and membrane trafficking.
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Epigenetics and autoimmunity
Disruption of the normal epigenetic pattern leads to the onset of human diseases, especially in genetically predisposed individuals.
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Nuclear receptor function
Nuclear receptors coordinate the transcription of gene networks in response to binding of ligands and play critical roles in nearly every aspect of vertebrate development and adult physiology.
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Epigenetic regulation of steroidogenesis
Epigenetics is defined as heritable changes in gene expression that does not alter the primary DNA sequence but are mitotically and transgenerationally inheritable. Epigenetic regulation is essential during organ development and works side by side with gene regulatory mechanisms involving transcription factors and DNA regulatory elements.
