Boardman, Neoma Tove

Stipendiat

Telefon (+47)
776 45450

E-mail
neoma.boardman@fagmed.uit.no

Kontor/besøk
L7.217C

Forskningsprosjekter
My PhD project focuses on the potential mechanisms of altered cardiac metabolism in type 2 diabetic cardiomyopathy and how this may lead to reduced cardiac efficiency in diabetic hearts. Altered metabolism, specifically enhanced fatty acid utilization, mitochondrial uncoupling as well as excess energy use for excitation-contraction coupling contribute to alterations in the relationship between myocardial oxygen consumption and cardiac work (reduced energy expenditure per unit work in the heart), thereby reducing cardiac efficiency.

Our experimental approach is to examine the relationship between total cardiac work (by means pressure-volume analysis of the left ventricle) and myocardial oxygen consumption in an ex vivo perfused heart. The primary objective of this research project is to delineate the mechanisms behind decreased cardiac efficiency in diabetic hearts as well as to examine potential strategies that may improve cardiac inefficiency in diabetic hearts.