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Terje Steinar Larsen
Professor
Telefon (+47)
776 44694
E-mail
terjel@fagmed.uit.no
Kontor/besøk
L7.225B
Verv
Medlem av arbeidsgruppe - arbeidsplikt for ansatte i kombinerte stillinger
Leder for bioingeniørutvalget, UiTø
Avdelingsleder, Avd. for medisinsk fysiologi
Forskningsprosjekter
Endringer i hjertets metabolisme og mekaniske funksjon som følge av diabetes (T. Larsen, E. Aasum, S. Bratkovsky, A.D. Hafstad) studeres i genetisk diabetiske (db/db) mus, som anses å være en god modell for type 2 diabetes. Modellen er godt etablert i laboratoriet, og det er allerede påvist en betydelig redusert hjertefunksjon og endret metabolisme (økt fettsyreforbrenning og redusert glukoseforbrenning) i hjerter fra disse dyrene. Vi har også dokumentert en betydelig redusert koronar vaskulær reaktivitet i disse hjertene. Det pågår studier for å undersøke hvordan genetiske og farmakologiske intervensjoner kan forebygge “det metabolske syndrom” i diabetes, og om dette i sin tur påvirker hjertets kontraktile og mikrosirkulatoriske funksjon. Vi har vist at lang-tids behandling av diabetiske mus med moderne antidiabetiske medikamenter (peroxisom proliferator-aktiverte reseptor agonister) effektivt kan motvirke høy konsentrasjon av glukose og fettstoffer i plasma fra diabetiske mus. Resultatene viser derimot kun moderat forbedring av hjertets mekaniske funksjon som følge av denne behandlingen. Disse studiene gjennomføres i samarbeid med David Seversons gruppe i Calgary, Canada.
Publikasjoner
Artikler i internasjonale tidsskrifter:
Aasum, Ellen; Cooper, Marie; Severson, David Lester; Larsen, Terje. Effect of BM 17.0744, a PPAR alpha ligand, on the metabolism of perfused hearts from control and diabetic mice. Canadian Journal Of Physiology And Pharmacology 2005;83:183-190
Bratkovski, Serguei; Aasum, Ellen; Birkeland, CH; Riemersma, Rudolph; Myhre, Eivind SP; Larsen, Terje. Measurement of coronary flow reserve in isolated hearts from mice. Acta Physiologica Scandinavica 2004;181:167-172
Carley, Andrew; Semeniuk, LM; Shimoni, Y; Aasum, Ellen; Larsen, Terje; Berger, JP; Severson, David Lester. Treatment of type 2 diabetic db/db mice with a novel PPAR gamma agonist improves cardiac metabolism but not contractile function. American Journal of Physiology. Endocrinology and Metabolism 2004;286:E449-E455
Henden, Thale; Aasum, Ellen; Folkow, Lars; Mjøs, Ole Danbolt; Lathrop, David A; Larsen, Terje. Endogenous glycogen prevents Ca2+ overload and hypercontracture in harp seal myocardial cells during simulated ischemia. Journal of Molecular and Cellular Cardiology 2004;37:43-50
Henden, Thale; Scrimgeour, A.G.; Folkow, Lars; Larsen, Terje. Glycogen metabolism in seal and pig myocardium during normoxic and ischemic conditions. Journal of Molecular and Cellular Cardiology 2005;38:1028-1028
How, Ole-Jacob; Aasum, Ellen; Kunnathu, S; Severson, David Lester; Larsen, Terje. Influence of substrate supply on cardiac efficiency, by pressure-volume analysis in ex vivo mouse hearts. Journal of Molecular and Cellular Cardiology 2004;36:735-735
How, Ole-Jacob; Aasum, Ellen; Kunnathu, S; Severson, David Lester; Myhre, Eivind S.p.; Larsen, Terje. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. American Journal of Physiology. Heart and Circulatory Physiology 2005;288:H2979-H2985
How, Ole-Jacob; Aasum, Ellen; Severson, David Lester; Larsen, Terje. Altered pressure-volume relationships in hearts from diabetic mice: a possible mechanism of diabetic cardiomyopathy?. Journal of Molecular and Cellular Cardiology 2005;38:1029-1029
Pellieux, Corrinne; Aasum, Ellen; Larsen, Terje; Montessuit, C; Papageorgiou, I; Pedrazzini, T; Lerch, R. Role of angii in metabolic phenotype adaptation during progression from cardiac phenotype to hearts failure. Journal of Molecular and Cellular Cardiology 2005;38:1057-1057
Vader, Marit Arianne; Essop, M Fadiel; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Acute effects of ppar ligands on cardiac metabolism. Journal of Molecular and Cellular Cardiology 2005;38:1077-1077
Von Lueder, Thomas; Vinge, Leif Erik; Aasum, Ellen; How, Ole-Jacob; Bjørnerheim, Reidar; Qvigstad, Eirik; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Cardiac-specific inhibition of G protein-couplet receptor kinase-3 transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype. Hjerteforum 2005;2(178)
Abstract til kongresser:
Aasum, Ellen; Khalid, Ahmed Murtaz; Gudbrandsen, Oddrun Anita; How, Ole-Jacob; Berge, Rolf; Larsen, Terje. Different effects of PPAR ligands on cardiac metabolism in mice fed high fat diet. [Vitenskapelig foredrag]. Second annual meeting of the Society for Heart and Vascular Metabolism; 09.09.2004 - 11.09.2004
Henden, Thale; Scrimgour, A.G.; Folkow, Lars; Larsen, Terje. Glycogen metabolism in seal and pig myocardium during normoxic and ischemic conditions [Poster]. European Section of International Society for Heart Research; 21.06.2005 - 25.06.2005
How, Ole-Jacob; Aasum, Ellen; Kunnathu, Stanley; Severson, David Lester; Larsen, Terje. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. [Vitenskapelig foredrag]. ISHR 2004. Publisert i: Journal of Molecular and Cellular Cardiology; 2004
How, Ole-Jacob; Aasum, Ellen; Severson, David Lester; Chan, A; Essop, M Fadiel; Larsen, Terje. Cardiac Efficiency is Reduced in Hearts from Diabetic Mice [Vitenskapelig foredrag]. 3rd. annual meeting of the Society for Heart and Vascular Metabolism; 26.09.2005 - 29.09.2005
How, Ole-Jacob; Aasum, Ellen; Severson, David Lester; Larsen, Terje. Altered pressure-volume relationships in hearts from diabetic mice: a possible mechanism of diabetic cardiomyopathy? [Poster]. European Section of International Society for Heart Research; 21.06.2005 - 25.06.2005. Publisert i: Journal of Molecular and Cellular Cardiology; 2005
Larsen, Terje. Altered metabolism and cardiomyopathy in the db/db mouse. [Vitenskapelig foredrag]. ESC Congress 2004. Publisert i: European Journal of Heart Failure; 2004
Larsen, Terje. Control of Cardiac Energy Metabolism by PPARs - Direct of Indirect effects. [Vitenskapelig foredrag]. Society for Heart and Vascular Metabolism 2004
Larsen, Terje. Control of energy metabolism in the diabetic heart [Vitenskapelig foredrag]. Diabetesforskningskongressen; 30.09.2004 - 01.10.2004
Larsen, Terje. Metabolic and Functional Alterations of the Diabetic Mouse Heart [Vitenskapelig foredrag]. Invitert gjesteforeleser; 06.12.2005 - 06.12.2005
Larsen, Terje. Reduced Efficiency in Hearts from Diabetic Mice [Vitenskapelig foredrag]. Invitert gjesteforeleser; 30.09.2005 - 30.09.2005
Pellieux, Corinne; Aasum, Ellen; Larsen, Terje; Montessuit, C; Papageorgiou, I; Pedrazzini, T; Lerch, R. Role of angii in metabolic phenotype adaption during progression from cardiac hypertrophy to heart failure [Poster]. European Section of International Society for Heart Research; 21.06.2005 - 25.06.2005. Publisert i: Journal of Molecular and Cellular Cardiology; 2005
Thalen, P; Egdley, D; Severson, David Lester; Aasum, Ellen; Larsen, Terje; Ljung, B; Oakes, Nick. Cardiac metabolic inflexibility in diabetic (db/db) mice as shown by assessment of free fatty acid and glucose utilization in vivo. [Poster]. Second annual meeting of the Society for Heart and Vascular Metabolism; 09.09.2004 - 11.09.2004
Vader, Marit Arianne; Essop, Faadiel; Hafstad, Anne Dragøy; Larsen, Terje; Aasum, Ellen. Acute effects of ppar ligands on cardiac metabolism [Poster]. European Section of International Society for Heart Research; 21.06.2005 - 25.06.2005. Publisert i: Journal of Molecular and Cellular Cardiology; 2005
Von Leuder, T; Vinge, LE; Aasum, Ellen; Qvigstad, E; Bjørnerheim, R; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Cardiac-specific inhibition of the receptor kinase GRK3 in transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype. [Vitenskapelig foredrag]. American Heart Associaction 2004. Publisert i: Circulation; 2004
Von Leuder, T; Vinge, LE; Aasum, Ellen; Qvigstad, E; Bjørnerheim, R; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Transgenic mice with cardiac-specific inhibition of GRK3 display phenotype with cardiac hypertrophy and alpha1-adrenergic receptor hyperresponsiveness. [Vitenskapelig foredrag]. ESC Meeting 2004. Publisert i: European Journal of Heart Failure; 2004
Von Lueder, Thomas; Vinge, Leif Erik; Aasum, Ellen; How, Ole-Jacob; Bjørnerheim, Reidar; Qvigstad, Eirik; Larsen, Terje; Smiseth, Otto A; Attramadal, Håvard. Cardiac-specific inhibition of G protein-couplet receptor kinase-3 transgenic mice causes preload-intolerant, hyperkinetic myocardium and hypertensive phenotype [Vitenskapelig foredrag]. Kardiologisk vintermøte; 28.01.2005 - 30.01.2005
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