Leif Jørgensen

Leif Jørgensen

Professor Emeritus

Phone (+47)
776 44 648

E-mail
leif.jorgensen@fagmed.uit.no

Office
L7.131

Qualifications
GRADUATIONS:

Graduated, Drammen Secondary School, Drammen, Norway, 1944 and 1948

Comple ted preclinical medical study at University of Uppsala, Uppsala, Sweden, 1947.

Graduated from Faculty of Medicine, University of Oslo, Oslo, Norway, 1952.

Authorization as physician in Norway, 1952

Specialist in Pathology in Norway, 1961

Created doctor medicinae (equivalent to Ph.D.), Faculty of Medicine, University of Oslo, 1964


POSITIONS

Internship: The Elizabeth General Hospital, Elizabeth, NJ, U.S.A. 1952-53.

Junior positions at departments of surgery and internal medicine, Gjøvik County Hospital, Gjøvik, and Ullevål Hospital, Oslo, Norway, in 1954 and 1956-57, respectively.

Assistant to District Physician in Sør-Varanger, Finnmark, Norway, with independent practice in Bjørnevatn, 1955-56.

Educational positions at departments of pathology, Ullevål Hospital and Rikshospitalet, Oslo, in 1957-59 and 1959-1961, respectively.

Assisting medical director at Department of Pathology, Ullevål Hospital, 1961-1971, and associate professor in pathology, University of Oslo, 1966-71

Professor in morphology (normal anatomy and pathology) at Institute of Medical Biology, University of Tromsø, and medical director at Department of Pathology, Regional Hospital of Tromsø, Tromsø, Norway, 1971-1984.

Assistant professor in forensic medicine at Institute of Forensic Medicine, University of Oslo, 1984-92.

Professor in forensic medicine at Institute of Medical Biology, University of Tromsø, and medical director at Department of Pathology, Regional Hospital of Tromsø, 1992-1999.

Medical director at Department of Pathology, Regional Hospital of Tromsø (from 2002: named University Hospital Northern Norway), and professor at University of Tromsø from 2000 up to now.


RESEARCH ENGAGEMENTS AT CANADIAN UNIVERSITIES DURING LEAVE OF ABSENCE FROM POSITIONS IN NORWAY

Visiting assistant professor at Department of Pathology, University of Toronto, Toronto, Ontario, 12 months, 1965.

Visiting professor at Department of Pathology, McMaster University, Hamilton, Ontario, 6 months, 1979.

Visiting professor at Department of Pathology, McMaster University, Hamilton, Ontario, 6
months, 1983.

OFFICES

University of Oslo: Member, Council of Medical Faculty, 1969-72.

University of Tromsø: Chairman, Users’Planning Committee for Temporary Building of Institute of Medial Biology (”Theory Building”), 1970-72.

University of Tromsø: Member, Council of Medical Faculty, 1971-73.

University of Tromsø: Representative of Medical Faculty in Common Planning Committee of permanent university campus, 1972-75.

University of Tromsø and County of Troms: Chairman, Users’ Advisory Committee for planning of permanent building for Medical Faculty and University Hospital, 1972-80.

University of Tromsø and County of Troms: Chairman, Planning Committee of permanent buildings for Medical Faculty and University Hospital, 1972-77.

University of Tromsø and County of Troms: Member, Planning Committee of permanent buildings for Medical Faculty and the University Hospital, 1978-80.

University of Tromsø and County of Troms: Acting Director of development of buildings for the Medical Faculty and University Clinic, 8 months, 1978.

Norwegian Council Member of Hospital Research, Trondheim: Member 1978-83.

Norwegian Society of Pathology and Norwegian Medical Association: Committee for Preparing a General Plan of Pathology in Norway, 1980-81.

Norwegian Medical Association: Chairman, Speciality Committee in Pathology, 1987-98.

Norwegian Commission of Forensic Medicine: Vice member, 1992-97.

Centre of Criminal Police: Identification Group, 1992-96.

Norwegian Society of Forensic Medicine: Member, Committee for Organisation of, and Education in Forensic Medicine in Norway, 1994-96.

Norwegian Society of Pathology: Chairman , Editorial Committee of 75th anniversary publication, 1997-98.

AWARDS

Professor Kreyberg’s Price for best scientific work in pathology in Norway in previous 4-years’ period, 1972.

Honorary member of Norwegian Society Of Pathology, 1995.

His Majesty the King’s Honorary Medal in Gold for valuable contribution to Norwegian medicine, 1998.

Fellow of American Heart Association, 2001.


RESEARCH

From 1958 to 2005 Leif Jørgensen was the main author or co-author of 112 scientific papers in medical journals, 85 original papers, 27 review articles.

The main topics have been pathological aspects of vascular diseases: thrombosis, haemostasis, atherosclerosis, infarction, platelet-endothelial interaction, and forensic medicine.

DISSERTION

Jørgensen, L.: Haemostasis and Thrombosis. Histological Studies. Universitetsforlaget, Oslo, Norway, 1964.


GUIDING OF RESEARCH FELLOWS

In the period 1972-2001 Leif Jørgensen guided 9 candidates for doctor’s degree at the Department of Morphology, University of Tromsø:
Dr. med. Berit Mørland
Dr. med. Einar A.Svendsen
Dr. med. Sigurd Lindal
Dr. med. Steinar Solberg
Dr. med. Elin Helset
Dr. sci. Beate Klemmetsen
Dr. med. Anna-Catharina Hegstad
Dr. sci. Madjid Delghandi
Dr. med. Ivar Sjåk Nordrum

Publications
LIST OF THE MOST IMPORTANT ORIGINAL AND REVIEW ARTICLES

Original papers:

Jørgensen L, Borchgrevink CF. The platelet plug in normal persons. 1. The histological appearance of the plug 15 to 20 minutes and 24 hours after the bleeding and its role in the capillary haemostasis. Acta Pathol Microbiol Scand 57:40-56,1963.

Jørgensen L, Borchgrevink CF. The haemostatic mechanism in patients with haemorrhagic diseases. A histological study of wounds made for primary and secondary bleeding time tests. Acta Pathol Microbiol Scand 60:55-82,1964.

Jørgensen L. Experimental platelet and coagulation thrombi. A histological study of arterial and venous thrombi of varying age in untreated and heparinized rabbits. Acta Pathol Microbiol Scand 62:189-223,1964.

Jörgensen L, Torvik A. Ischaemic cerebrovascular diseases in an autopsy series. Part 1. Prevalence, location and predisposing factors in verified thrombo-embolic occlusions, and their significance in the pathogenesis in cerebral infarction. J Neurol Sci 3:490-509,1966.

Jørgensen L, Rowsell HC, Hovig T, Glynn MF, Mustard JF. Adenosine diphosphate-induced platelet aggregation and myocardial infarction in swine. Lab Invest 17:616-644,1967.

Jørgensen L, Rowsell HC, Hovig T, Mustard JF. Resolution and organization of platelet-rich mural thrombi in carotid arteries of swine. Amer J Pathol 51:681-719,1967.

Jørgensen L, Hærem JW, Chandler AB, Borchgrevink CF. The pathology of acute coronary death. Acta Anaesthesiol Scand (Suppl.29):193-199,1968.

Jörgensen L, Torvik A. Ischaemic cerebrovascular diseases in an autopsy series. Part 2. Prevalence, location, pathogenesis, and clinical course of cerebral infarcts. J Neurol Sci 9:285-320,1969.

Jørgensen L, Hovig T, Rowsell HC, Mustard JF. Adenosine diphosphate-induced platelet aggregation and vascular injury in swine and rabbits. Amer J Pathol 6l:161-176,1970.

Jørgensen L, Glynn MF, Hovig T, Murphy EA, Buchanan MR, Mustard JF. Renal lesions and rise in blood pressure caused by adenosine diphosphate-induced platelet aggregation in rabbits. Lab Invest 23:347-357,1970.

Jørgensen L, Chandler AB, Borchgrevink F. Acute lesions of coronary arteries in anticoagulant-treated and in untreated patients. Atherosclerosis 13:21-44,1971.

Jørgensen L, Packham MA, Rowsell HC, Mustard JF. Desposition of formed elements of blood on the intima and signs of intimal injury in the aorta of rabbit, pig, and man. Lab Invest 27:34l-350,1972.

Jørgensen L, Hærem JW, Moe N. Platelet thrombosis and non-traumatic intimal injury in mouse aorta. Thrombos Diathes Haemorrh 29:470-489,1973

Jørgensen L, Nordal EJ, Eide TJ, Svendsen EA, Bostad LH, Engh TV, Blom GP. The relationship between atherosclerosis of the thoracic aorta and renal scarring in an autopsy material. Acta Pathol Microbiol Immunol Scand (Sect. A) 93:25l-255,1985.

Jørgensen L, Grøthe AG, Larsen T, Kinglough-Rathbone RL, Mustard JF. Injury to cultured endothelial cells by thrombin-stimulated platelets. Lab Invest 54:408-415,1986.

Jørgensen L, Grøthe AG, Groves HM, Kinlough-Rathbone RL, Richardson M, Mustard JF. Distribution of cellular responses in rabbit aortae following one and two injuries with a balloon catheter. Br J Exp Pathol 69:351-365,1988

Jørgensen L, Grøthe AG, Groves HM, Kinlough-Rathbone RL, Richardson M, Mustard JF. Sequence of cellular responses in rabbit aortas following one and two injuries with a balloon catheter. Br J Exp Pathol 69:473-486,1988.

Jørgensen L, Nilsen GJ, Perry DW, Mustard JF, Kinlough- Rathbone RL: Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy. Scand J Clin Lab Invest 53:711-724,1993.

Jørgensen L, Mustard JF, Kinlough-Rathbone, RL: Platelet deposition in rabbit carotid arteries promoted by arterial stenosis and spasm. Manuscript ready to be submitted, 2005.

Review articles:

Jørgensen L: The role of platelet embolism from crumbling thrombi and of platelet aggregates arising in flowing blood. In: Sherry S, Brinkhous KM, Genton E & Stengle JM (eds.): Thrombosis. National Academy of Sciences, Washington, DC: 506 533,1969.

Jørgensen L: Thrombosis and the complications of
atherosclerosis. In: Jones RJ (ed.): Atherosclerosis.Proceedings of the Second International Symposium. Springer Verlag, New York, Heidelberg, Berlin: 94 102,1970

Jørgensen L: Mechanisms of thrombosis. Ioachim HL (ed.): Pathobiology Annual, Appleton Century Crofts, Meredith Corporation, New York:139 204,1971.

Jørgensen L: Vessel wall and thrombogenesis: vascular injury, atherosclerosis. Thrombos Diathes Haemorrh (Suppl.54):309 314,1973.

Jørgensen L: Platelets and endothelial cell injury.
In: Carlson LA, Paoletti R, Sirtori CR, Weber G (eds.): International Conference on Atherosclerosis, Raven Press, New York:615 621,1978.

Jørgensen L: Historical sketch: ADP-induced platelet aggregation in the microcirculation of pig myocardium and rabbit kidneys. J Thromb Haemostas 3: 1119-1124, 2005.