Ugo Moens

Position:   Professor

E-mail  ugom@fagmed.uit.no

Telephone:   44661/44653

Teachings:
BIO-1001
Genetics
uit.no/medfak-studietilbud/biologi-emner/1

BIO-3302
Eukaryotic transcription factors and cellular signalling, 10 ects
uit.no/medfak-studietilbud/biologi-emner/12

BIO-3312
Mammalian cell culture, 5 ects
uit.no/medfak-studietilbud/biologi-emner/22

BIO-3315
Virology, 10 ects
uit.no/medfak-studietilbud/biologi-emner/25

BIO-8302, BIO-8303, BIO-8304
Molecular and Clinical Aspects of Cancer

Introduction Biomedicine - Virology part

Biomedicine cell biology

Publications:
Johannessen, M. and Moens, U. (2007). Multisite phosphorylation of the cAMP response element-binding protein (CREB) by a diversity of protein kinases. Frontiers in Bioscience; 12:1814-1832.

Gerits, N., Kostenko, S. and Moens, U. In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice. Transgene Research; in press.

Mikalsen, T., Gerits, N. and Moens, U. (2006). Inhibitors of signal transduction protein kinases as targets for cancer therapy. Biotechn. Annu. Rev, 12:158-229.

Rekvig, OP., Bendiksen, S. and Moens, U. (2006). Immunity and autoimmunity induced by polyomaviruses: clinical, experimental and theoretical aspects.
Adv Exp Med Biol, 577:117-147.

Pankiv, P., Møller, S., Bjørkøy, G., Moens, U., Huseby, NE. (2006) Radiation-induced upregulation of gamma-glutamyltransferase in colon carcinoma cells is mediated through the Ras signal transduction pathway. Biochim Biophys Acta, 1760:151-157.

Martin-Armas, M., Simon-Santamaria, J., Pettersen, I., Moens, U., Smedsrød, B., Sveinbjørnsson, B. (2006) Toll like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediated the effect of CpG-oligonucleotides. J. Hepatol, 44:939-946.

Johannessen, M. and Moens, U. (2005). Transcription of Genes in Response to Activated cAMP-Protein Kinase A Signaling Pathway: There is More to it Than CREB. Trends in Cellular Signalling (Ed. Caplin,DE) Nova Publisher; ISBN:1-59454-633-9

Johannessen, M., Møller, S., Hansen, T., Moens, U., and Van Ghelue, M. (2006). The multifunctional roles of four-and-a-half LIM only protein. Cell Mol Life Sci, 63:268-284.

Mikalsen, T., Johannessen, M., and Moens, U. (2005) Sequence- and position-dependent tagging protects extracellular-regulated kinase 3 protein from 26S proteasome-mediated degradation. Int. J. Biochem. Cell. Biol,37:2513-20.

Pedersen Delghandi, M., Johannessen, M., and Moens, U. (2005) The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH3T3 cells. Cell Signall., 17:1343-1351.

Moens, U., and Van Ghelue, M. (2005). Polymorphism in the genome of non-passaged human polyomavirus BK: implications for cell tropism and the pathological role of the virus. Virology 3312:209-31.

Seternes, O.M., Mikalsen, T., Johansen, B., Michaelsen, E., Armstrong, C.G., Morrice, N.A., Moens, U., and Keyse, S.M. (2004). Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. EMBO J. 23:4780-91.

Bendiksen, S*, Van Ghelue, M*, Winkler T, Moens, U., and Rekvig O.P. (2004). B cell and T cell autoimmunity to DNA and nucleosomes in binary tetracycline-regulated polyomavirus T-antigen transgenic mice. J. Immunol., 173:7630-40.
(*both authors contributed equally)

Johannessen, M., Pedersen Delghandi, M., and Moens, U. (2004). What turns CREB on? Cell Signall.; 10:1211-1227.

Johannessen, M., Pedersen Delghandi, M., Seternes, O.M., Johansen, B., and Moens, U. (2004). Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain.Cell Signall. 10:1187-1899.

Hendrickx, N., Volanti, C., Moens, U., Seternes, O.M., de Wittte, P., Vandenheede, J.R., Piette, J., and Agostinis, P. (2003). Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. J. Biol. Chem. 278:52231-52239.

Van Ghelue M., Moens, U., Bendiksen, S., and Rekvig, O.P. (2003). Autoimmunity to nucleosomes related to viral infection: a focus on hapten-carrier complex formation. J. Autoimmun. 20: 171-182.

Johannessen, M., Olsen, P.A., Søresen, R., Johansen, B., Seternes, O.M., and Moens, U. (2003). A role of the TATA box and the general co-activator hTAFII130/135 in promoter-specific trans-activation by simian virus 40 small t antigen. J. Gen. Virol. 84: 1887-1897.

Johannessen, M., Olsen, P.A., Johansen, B., Seternes, O.M., and Moens, U. (2003). Activation of the coactivator four-and-a-half-LIM-only protein FHL2 and the c-fos promoter through inhibition of protein phosphatase 2A. (2003). Biochem. Pharmacol. 65: 1317-1328.

Seternes, O.M., Johansen, B., Hegge, B., Johannessen, B., Keyse, S.M., and Moens, U. (2002). Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress. Mol. Cell. Biol. 22: 6931-6945.

Mikkelsen, I.M., Huseby, N.-E., Visvikis, A., and Moens, U. (2002). Activation of the g-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding site. Biochemical Pharmacology, 64(2):307-15.

Andreassen, K., Bendiksen, S., Kjeldsen, E., Van Ghelue, M., Moens, U., Arnesen, E., and Rekvig, OP. (2002). Systemic lupus erythematosus-related T-cell autoimmunity to histones and nucleosomes is an inherent property of the normal immune system. Arthr. Rheum. 46:1270-1281.

Moens, U., Mathiesen, I., Van Ghelue, M., and Rekvig, OP. (2002). Green fluorescent protein modified to bind DNA initiates production of anti-DNA antibodies when expressed in vivo. Mol. Immunol. 38(7):505-514.

Rekvig, O.P., and Moens, U. (2002). Polyomavirus BK and autoimmunity to nucleosomes. Graft 5: S36-S45.

Moens, U., Van Ghelue, M., Kristoffersen, AK., Johansen, B., Rekvig, OP., Degré, M., and Rollag, H. (2001). Simian virus 40 large T-antigen, but not small t-antigen, trans-activates the human cytomegalovirus major immediate early promoter. Virus Gen. 23: 215-226.

Bredholt, G, Rekvig OP, Andreassen K, Moens U, Marion TN. (2001). Differences in the reactivity of CD4+ T cell lines generated against free versus nucleosome-bound SV40 large T-antigen. Scand. J. Immunol. 53: 372-380.

Bendiksen, S, Rekvig OP, Van Ghelue M, Moens U. (2000) VP1 DNA sequences of JC and BK viruses detected in urine of systemic lupus erythematosus patients reveals no differences with strains expressed in normal individuals. J. Gen. Virol. 81:2625-2633.

Bendiksen S, Van Ghelue M, Rekvig OP, Gutteberg T, Haga HJ, Moens U. (2000). A longitudinal study of human cytomegalovirus serology and viruria fails to detect active viral infection in 20 systemic lupus erythematosus patients. Lupus. 9:120-6.

Bredholt G, Olaussen E, Moens U, Rekvig OP. (1999). Linked production of antibodies to mammalian DNA and to human polyomavirus large T antigen: footprints of a common molecular and cellular process? Arthritis Rheum. 42(12):2583-92.

Andreassen K, Moens U, Nossent H, Marion TN, Rekvig OP. (1999). Termination of human T cell tolerance to histones by presentation of histones and polyomavirus T antigen provided that T antigen is complexed with nucleosomes. Arthritis Rheum. 42(11):2449-60.

Shadidy M, Caubit X, Olsen R, Seternes OM, Moens U, Krauss S. (1999). Biochemical analysis of mouse FKBP60, a novel member of the FKPB family. Biochim Biophys Acta. 1446(3):295-307.

Andreassen K, Bredholt G, Moens U, Bendiksen S, Kauric G, Rekvig OP. (1999). T cell lines specific for polyomavirus T-antigen recognize T-antigen complexed with nucleosomes: a molecular basis for anti-DNA antibody production. Eur J Immunol. 1999 29(9):2715-28.

Boe R, Silvola J, Yang J, Moens U, McCray PB Jr, Stenfors LE, Seljfelid R. (1999). Human beta-defensin-1 mRNA is transcribed in tympanic membrane and adjacent auditory canal epithelium. Infect Immun. 67(9):4843-6.

Seternes OM, Johansen B, Moens U. (1999). A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells. Mol Endocrinol. 13:1071-83.

Sundsfjord A, Osei A, Rosenqvist H, Van Ghelue M, Silsand Y, Haga HJ, Rekvig OP, Moens U. (1999). BK and JC viruses in patients with systemic lupus erythematosus: prevalent and persistent BK viruria, sequence stability of the viral regulatory regions, and nondetectable viremia. J Infect Dis. 180:1-9.

Seternes OM, Sorensen R, Johansen B, Moens U. (1999). Activation of protein kinase A by dibutyryl cAMP treatment of NIH 3T3 cells inhibits proliferation but fails to induce Ser-133 phosphorylation and transcriptional activation of CREB. Cell Signal. 11:211-9.

Moens U, Van Ghelue M, Johansen B, Seternes OM. (1999). Concerted expression of BK virus large T- and small t-antigens strongly enhances oestrogen receptor-mediated transcription. J Gen Virol. 80:585-94.

Jensen I, Rinaldo CH, Nordbo Berge L, Seternes OM, Moens U. (1998). Human umbilical vein endothelial cells lack expression of the estrogen receptor. Endothelium. 6:9-21.

Rekvig OP, Andreassen K, Moens U. (1998). Antibodies to DNA--towards an understanding of their origin and pathophysiological impact in systemic lupus erythematosus. Scand J Rheumatol. 27:1-6.

Tryland M, Sandvik T, Hansen H, Haukenes G, Holtet L, Bennett M, Mehl R, Moens U, Olsvik O, Traavik T. (1998). Characteristics of four cowpox virus isolates from Norway and Sweden. APMIS. 106:623-35.

Sandvik T, Tryland M, Hansen H, Mehl R, Moens U, Olsvik O, Traavik T. (1998). Naturally occurring orthopoxviruses: potential for recombination with vaccine vectors. J Clin Microbiol. 36:2542-7.

Seternes OM, Sorensen R, Johansen B, Loennechen T, Aarbakke J, Moens U. (1998). Synergistic increase in c-fos expression by simultaneous activation of the ras/raf/map kinase- and protein kinase A signaling pathways is mediated by the c-fos AP-1 and SRE sites. Biochim Biophys Acta. 1395:345-60.

Loennechen T, Moens U, Kildalsen H, Andersen A, Rekvig OP, Aarbakke J. (1997). Effects of 3-deazaadenosine on apoptosis-related gene transcripts in HL-60 cells. Pharmacol Toxicol. 81:199-204.

Rekvig OP, Moens U, Sundsfjord A, Bredholt G, Osei A, Haaheim H, Traavik T, Arnesen E, Haga HJ. (1997). Experimental expression in mice and spontaneous expression in human SLE of polyomavirus T-antigen. A molecular basis for induction of antibodies to DNA and eukaryotic transcription factors. J Clin Invest. 99:2045-54.

Rekvig OP, Moens U, Fredriksen K, Traavik (1997). T. Human polyomavirus BK and immunogenicity of mammalian DNA: a conceptual framework. Methods. 11:44-54.

Moens U, Seternes OM, Johansen B, Rekvig OP. (1997). Mechanisms of transcriptional regulation of cellular genes by SV40 large T- and small T-antigens. Virus Genes. 15:135-54.

Moens U, Seternes OM, Hey AW, Silsand Y, Traavik T, Johansen B, Rekvig OP. (1995). In vivo expression of a single viral DNA-binding protein generates systemic lupus erythematosus-related autoimmunity to double-stranded DNA and histones. Proc Natl Acad Sci U S A. 92:12393-7.

Moens U, Johansen T, Johnsen JI, Seternes OM, Traavik T. (1995). Noncoding control region of naturally occurring BK virus variants: sequence comparison and functional analysis. Virus Genes. 10:261-75.

Johnsen JI, Seternes OM, Johansen T, Moens U, Mantyjarvi R, Traavik T. (1995). Subpopulations of non-coding control region variants within a cell culture-passaged stock of BK virus: sequence comparisons and biological characteristics. J Gen Virol. 76 :1571-81.

Rekvig OP, Fredriksen K, Hokland K, Moens U, Traavik T, Krishnan MR, Marion T.(1995). Molecular analyses of anti-DNA antibodies induced by polyomavirus BK in BALB/c mice. Scand J Immunol. 41:593-602. (erratum appeared in Scand J Immunol. 1995 Aug;42(2):286).

Moens U, Subramaniam N, Johansen B, Johansen T, Traavik T. (1994). A steroid hormone response unit in the late leader of the noncoding control region of the human polyomavirus BK confers enhanced host cell permissivity. J Virol. 68:2398-408.

Moens U, Subramaniam N, Johansen B, Aarbakke J. (1993). The c-fos cAMP-response element: regulation of gene expression by a beta 2-adrenergic agonist, serum and DNA methylation. Biochim Biophys Acta. 1173:63-70.

Johansen T, Moens U, Holm T, Fjose A, Krauss S. (1993). Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed during embryogenesis. Nucleic Acids Res. 21:475-83.

Loennechen T, Nilsen IW, Moens U, Andersen A, Aarbakke J. (1992). Is there an association between an increase in c-myc RNA steady state levels and c-myc methylation in HL-60 cells treated with 3-deaza-(+/-)-aristeromycin, an indirect inhibitor of methylation? Biochem Pharmacol. 44:1283-9.

Rekvig OP, Fredriksen K, Brannsether B, Moens U, Sundsfjord A, Traavik T. (1992). Antibodies to eukaryotic, including autologous, native DNA are produced during BK virus infection, but not after immunization with non-infectious BK DNA. Scand J Immunol. 36:487-95.

Krauss S, Johansen T, Korzh V, Moens U, Ericson JU, Fjose A. (1991). Zebrafish pax[zf-a]: a paired box-containing gene expressed in the neural tube. EMBO J. 10:3609-19.

Moens U, Villand P, Johansen B, Traavik T. (1991). A simple and convenient method to standardizate transient of chloramphenicol acetyltransferase activity. Methods Mol Cell Biol 2:169-175.

Sundsfjord A, Johansen T, Flaegstad T, Moens U, Villand P, Subramani S, Traavik T. (1990). At least two types of control regions can be found among naturally occurring BK virus strains. J Virol. 64:3864-71.

Moens U, Sundsfjord A, Flaegstad T, Traavik T. (1990). BK virus early RNA transcripts in stably transformed cells: enhanced levels induced by dibutyryl cyclic AMP, forskolin and12-O-tetradecanoylphorbol-13-acetate treatment. J Gen Virol. 71:1461-71.

Moens U, Bang BE, Aarbakke J.(1990). Physiological cyclic AMP stimulation and oncogene mRNA levels in HL-60 cells. Life Sci. 47:1555-60.

Moens U, Wold I, Mathiesen SD, Jorgensen T, Sorensen D, Traavik T. (1990). Parapoxvirus papillomatosis in the muskoxen (Ovibos moschatus): genetical differences between the virus causing new outbreak in a vaccinated herd, the vaccine virus and a local orf virus. Acta Vet Scand. 31:17-25.

Moens U, Rombaut B, Thomas A.A.M., Vrijsen R, Boeyé A. (1984). Formation of poliovirus maturation intermediates in a cell-free system. Arch. Int. Physiol. Biochim. 92:153-154.




Reviews (Norwegian)

Moens, U., Van Ghelue, M., Bendiksen, S., and Rekvig, O.P. (2002). Humane polyomavirus og systemisk lupus erythematosus (SLE). Norsk Farmaceutisk Tidsskrift 4: 16-19.

Book chapters

Johannessen, M. and Moens, U. Transcription of genes in response to activated cAMP/protein kinase A signaling pathway: There is more to it than CREB. Trends in cellular Signaling. Caplin, D.E. (ed.). Nova Publisher. ISBN:1-59454-633-9.

Rekvig OP, Bendiksen S, and Moens U. Immunity and autoimmunity induced by polyomaviruses. Clinical, experimental and theoretical aspects. In Human polyomaviruses and disease. (2006)577:117-147.

Moens U, Rekvig OP. Molecular Biology of BK Virus and Basic and Clinical Aspects of BK Virus Renal Infection. In: The Human Polyomaviruses JC, BK, and SV40: Molecular and Clinical Perspectives. (K. Khalili and G.L. Stoner, eds). Wiley and Sons, New York. 2001. Pp.359-408.

Traavik T, Sundsfjord A, Johansen T, Flægstad T, Moens U, Villand P, Subramani S. (1991). Characterization of Non-Coding Control Regions of BK Virus DNA. In: Application of Molecular Biology in Diagnosis of Infectious Diseases (Olsvik Ø, Bukholm G, eds). pp. 119-124.