Experimental Organic Synthesis

Aim and Content

The course will introduce the student to practical use of the library when synthetic work is to be planned and performed. Both manual use of the library and applications of electronic data bases will be demonstrated. Through various synthetic works, the student will be trained in purification procedures and various experimental methods. The use and limitations of the most common analytical methods like IR and UV/VIS will particularly be the subject of exercises. The security aspect will be a central theme in the laboratory course.

Learning Outcomes

After completing the course KJEM232 the student will:

• be able to analyze and draw flowcharts for multi-step processes and syntheses;
• be familiar with a selection of important chemical reactions and multi-step syntheses and processes that are used in the synthesis of important organic compounds;
• know how to write reaction schemes and mechanisms for a variety of organic transformations;
• know how to plan and conduct experimental work in organic synthesis and be familiar with the apparatus and glass equipment commonly used;
• know how to write synthesis tables, calculate yields and some green chemistry parameters, and keep concise laboratory records and use this to prepare proper reports about the experiments and present the results orally.

Course offered (semester)

Autumn (limited capacity). Master students have priority.

Language of Instruction

English

Pre-requirements

Basic principles of general and organic chemistry.

KJEM110, KJEM130, KJEM131 or equivalent.

Recommended previous knowledge

KJEM 231 Advanced organic chemistry (it is recommended to study 231 and 232 contemporary) and KJEM230 Analytic organic chemistry (or equivalent).

Subject Overlap

K231: 5stp, K242: 5 stp

Compulsory Requirements

Laboratory course with journal and two larger reports, use of instruments, oral presentations, some written exercises.

Assessment methods

The portfolio assessment is based on:

- The laboratory course (criteria given in advance) (25%)

- Laboratory journal, reports, other written exercises and oral presentations (25%)

- Oral exam (50%). (In case more than 4 candidates are registered, the examination may be written (2h)).

Supplementary exam-regulations:

1. In semesters with teaching: all compulsory parts must be carried out during the semester. Access to the final exam will be possible only if all compulsory parts are passed.

2. In semesters without teaching:

- Students with approved compulsory parts from previous semester can take a final exam, which then will account for the grade together with the compulsory parts from previous semester (laboratory course (criteria given in advance): 25%, laboratory journal, reports, other written exercises and oral presentations: 25% and final exam: 50%)

- Students without approved compulsory parts from previous semester can not take exam.
Compulsory work must be submitted within the given deadlines for the course. Approval of the compulsory work is necessary to get admittance to the written exam.

Grading Scale

The grading scale used is A to F. Grade A is the highest passing grade in the grading scale, grade F is a fail.