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α11β1 integrin-mediated MMP-13-dependent collagen lattice contraction by fibroblasts: evidence for integrin-coordinated collagen proteolysis.
The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation.
After 25 years of research on integrins, the picture of how integrins have evolved is becoming clearer. At the same time, model organism will continue to offer valuable systems to elucidate the function of integrins in different tissues.