Goals
The overriding goal of the lab is to elucidate the molecular mechanisms, regulation, and functions of long-term synaptic plasticity in relation to specific neural circuits in the adult brain. Our multidisciplinary approach combines electrophysiological studies in live rats and brain slices with molecular biological and imaging techniques including time-lapse multiphoton microscopy.
Research Topics:
- Molecular mechanisms of long-term potentiation consolidation.
- Dendritic protein synthesis and translational control.
- Sleep and state-dependent regulation of synaptic plasticity.
- Synaptic plasticity in the pathogenesis of mood disorders
