Lactic acid bacteria and bacteriocins

  • Purification, characterization and gene sequence of michiganin type B lantibiotic produced by the tomato pathogen Clavibacter michiganensis subsp. michiganensis; I. Holtsmark, D. Mantzilas, V.G.H. Eijsink, M.B. Brurberg; Appl. Environm. Microbiol. 72(2006) 5814-5821.
  • The tomato pathogen Clavibacter michiganensis subsp. michiganensis: producer of a broad spectre of antimicrobial substances; I. Holtsmark, D. Mantzilas, V.G.H. Eijsink, M.B. Brurberg; J. Appl. Microbiol., in press.
  • Mathiesen, G., Axelsen, G., Axelsson, L., and Eijsink, V. (2006) Isolation of constitutive variants of a subfamily 10 histidine protein kinase (SppK) from Lactobacillus using random mutagenesis. Arch Microbiol 184: 327-334. pdf
  • Eijsink, V.G., & Axelsson, L. (2005) Bacterial lessons in sausage making. Nat Biotechnol 23: 1494-1495. pdf
  • Mathiesen, G., Huehne, K., Kroeckel, L., Axelsson, L., and Eijsink, V.G.H. (2005) Characterization of a new bacteriocin operon in sakacin P-producing Lactobacillus sakei, showing strong translational coupling between the bacteriocin and immunity genes. Appl Environ Microbiol 71: 3565-3574. pdf
  • Sørvig, E., Skaugen, M., Naterstad, K., Eijsink, V.G., and Axelsson, L. (2005) Plasmid p256 from Lactobacillus plantarum represents a new type of replicon in lactic acid bacteria, and contains a toxin-antitoxin-like plasmid maintenance system. Microbiology 151: 421-431. pdf
  • Sørvig, E., Mathiesen, G., Naterstad, K., Eijsink, V.G.H., and Axelsson, L. (2005) High-level, inducible gene expression in Lactobacillus sakei and Lactobacillus plantarum using versatile expression vectors. Microbiology 151: 2439-2449. pdf
  • Mathiesen, G., Namløs, H.M., Risøen, P.A., Axelsson, L., and Eijsink, V.G.H. (2004) Use of bacteriocin promoters for gene expression in Lactobacillus plantarum C11. J Appl Microbiol 96: 819-827. pdf
  • Vaughan , A., Mahony, J.O., Eijsink, V.G.H., O'Connell-Motherway, M., and van Sinderen, D. (2004) Transcriptional analysis of bacteriocin production by malt isolate Lactobacillus sakei 5. FEMS Microbiol Lett 235: 377-384. pdf
  • Sørvig, E., Grönqvist, S., Naterstad, K., Mathiesen, G., Eijsink, V.G.H., and Axelsson, L. (2003) Construction of vectors for inducible gene expression in Lactobacillus sakei and L. plantarum. FEMS Microbiol Lett 229: 119-126. pdf
  • Vaughan , A., Eijsink, V.G.H., and van Sinderen, D. (2003) Functional characterization of a composite bacteriocin locus from malt isolate Lactobacillus sakei 5. Appl Environ Microbiol 69: 7194-7203. pdf
  • Eijsink, V.G.H., Axelsson, L., Diep, D.B., Håvarstein, L.S., Holo, H., and Nes, I.F. (2002) Production of class II bacteriocins by lactic acid bacteria; an example of biological warfare and communication. Antonie Van Leeuwenhoek 81: 639-654. pdf
  • Fimland, G., Eijsink, V.G.H., and Nissen-Meyer, J. (2002a) Comparative studies of immunity proteins of pediocin-like bacteriocins. Microbiology 148: 3661-3670. pdf
  • Fimland, G., Eijsink, V.G.H., and Nissen-Meyer, J. (2002b) Mutational analysis of the role of tryptophan residues in an antimicrobial peptide. Biochemistry 41: 9508-9515. pdf
  • Vaughan , A., Eijsink, V.G.H., O'Sullivan, T.F., O'Hanlon, K., and van Sinderen, D. (2001) An analysis of bacteriocins produced by lactic acid bacteria isolated from malted barley. J Appl Microbiol 91: 131-138. pdf
  • Fimland, G., Johnsen, L., Axelsson, L., Brurberg, M.B., Nes, I.F., Eijsink, V.G.H., and NissenMeyer, J. (2000) A C-terminal disulfide bridge in pediocin-like bacteriocins renders bacteriocin activity less temperature dependent and is a major determinant of the antimicrobial spectrum. J Bacteriol 182: 2643-2648. pdf
  • Johnsen, L., Fimland, G., Eijsink, V., and Nissen-Meyer, J. (2000) Engineering increased stability in the antimicrobial peptide pediocin PA-1. Appl Environ Microbiol 66: 4798-4802. pdf
  • Risøen, P.A., Brurberg, M.B., Eijsink, V.G.H., and Nes, I.F. (2000) Functional analysis of promoters involved in quorum sensing-based regulation of bacteriocin production in Lactobacillus. Mol Microbiol 37: 619-628. pdf
  • Hauge, H.H., Mantzilas, D., Eijsink, V.G., and Nissen-Meyer, J. (1999) Membrane-mimicking entities induce structuring of the two-peptide bacteriocins plantaricin E/F and plantaricin J/K. J Bacteriol 181: 740-747. pdf
  • Nes, I.F., and Eijsink, V.G.H. (1999) Regulation of group II peptide bacteriocin synthesis by quorum-sensing mechanisms. In Cell-Cell Signaling in Bacteria. Dunny, G.M. and Winans , S.C. (eds). Washington , D.C: American Society for Microbiology, pp. 175-192. No pdf available.
  • Remiger, A., Eijsink, V.G.H., Ehrmann, M.A., Sletten, K., Nes, I.F., and Vogel, R.F. (1999) Purification and partial amino acid sequence of plantaricin 1.25 a and 1.25 b, two bacteriocins produced by Lactobacillus plantarum TMW1.25. J Appl Microbiol 86: 1053-1058. pdf
  • Anderssen, E.L., Diep, D.B., Nes, I.F., Eijsink, V.G.H., and Nissen-Meyer, J. (1998) Antagonistic activity of Lactobacillus plantarum C11: two new two-peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin A. Appl Environ Microbiol 64: 2269-2272. pdf
  • Axelsson, L., Katla, T., Bjørnslett, M., Eijsink, V.G.H., and Holck, A. (1998) A system for heterologous expression of bacteriocins in Lactobacillus sake. FEMS Microbiol Lett 168: 137-143. pdf
  • Eijsink, V.G.H., Skeie, M., Middelhoven, P.H., Brurberg, M.B., and Nes, I.F. (1998) Comparative studies of class IIa bacteriocins of lactic acid bacteria. Appl Environ Microbiol 64: 3275-3281. pdf
  • Hauge, H.H., Mantzilas, D., Moll, G.N., Konings, W.N., Driessen, A.J.M., Eijsink, V.G.H., and Nissen Meyer, J. (1998a) Plantaricin A is an amphiphilic alpha-helical bacteriocin-like pheromone which exerts antimicrobial and pheromone activities through different mechanisms. Biochemistry (Mosc) 37: 16026-16032. pdf
  • Hauge, H.H., Nissen-Meyer, J., Nes, I.F., and Eijsink, V.G. (1998b) Amphiphilic a-helices are important structural motifs in the a and b peptides that constitute the bacteriocin lactococcin G-enhancement of helix formation upon a-b interaction. Eur J Biochem 251: 565-572. pdf
  • Brurberg, M.B., Nes, I.F., and Eijsink, V.G.H. (1997) Pheromone-induced production of antimicrobial peptides in Lactobacillus. Mol Microbiol 26: 347-360. pdf
  • Nissen-Meyer, J, H.H. Hauge, G. Fimland, V.G.H. Eijsink, I.F. Nes. (1997) Ribosomally synthesized antimicrobial peptides produced by lactic acid bacteria: their function, structure, biogenesis, and their mechanism of action. Recent Research Developments in Microbiology 1 (1997) 141-154. No pdf available.
  • Eijsink, V.G.H., Brurberg, M.B., Middelhoven, P.H., and Nes, O.F. (1996) Induction of bacteriocin production in Lactobacillus sake by a secreted peptide. J Bacteriol 178: 2232-2237. pdf
  • Nes, I.F., Diep, D.B., Håvarstein, L.S., Brurberg, M.B., Eijsink, V.G.H., and Holo, H. (1996) Biosynthesis of bacteriocins in lactic acid bacteria. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology 70: 113-128. No pdf available.

Patent

  • Eijsink, V.G.H., Brurberg, M.B., and Nes, I.F. (1995) Expression system in microorganisms and its use for expressing heterologous and homologous proteins. In International patent application PCT/NO96/00266.